GSK 0660 from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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GSK 0660

Selective PPARδ antagonist

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Tocris Bioscience, a Bio-Techne Brand for
GSK 0660

Description

Selective PPARδ antagonist

Product Specs
ItemGSK 0660
CompanyTocris Bioscience, a Bio-Techne Brand
Price $269.00Supplier Page View Company Product Page
Catalog Number3433/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight418.49
Molecule Name3-[[[2-Methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid methyl ester
FormulaC19H18N2O5S2
StorageStore at +4°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Activation of peroxisome proliferator-activated receptor delta suppresses BACE1 expression by up-regulating SOCS1 in a JAK2/STAT1-dependent mannerJournal of neurochemistryNovember 1, 2019Lee WJ, Ham SA, Lee GH, Choi MJ, Yoo H, Paek KS, Lim DS, Hong K, Hwang JS, Seo HG.

(2) Identification and characterization of a novel anti-inflammatory lipid isolated from Mycobacterium vaccae, a soil-derived bacterium with immunoregulatory and stress resilience propertiesPsychopharmacologyMay 1, 2019Smith DG, Martinelli R, Besra GS, Illarionov PA, Szatmari I, Brazda P, Allen MA, Xu W, Wang X, Nagy L, et al.

(3) Bladder-cancer-associated mutations in RXRA activate peroxisome proliferator-activated receptors to drive urothelial proliferationeLifeNovember 16, 2017Halstead AM, Kapadia CD, Bolzenius J, Chu CE, Schriefer A, Wartman LD, Bowman GR, Arora VK.

(4) Retinoic acid inhibits white adipogenesis by disrupting GADD45A-mediated Zfp423 DNA demethylationJournal of molecular cell biologyAugust 1, 2017Wang B, Fu X, Zhu MJ, Du M.

(5) Activation of PPAR-δ induces microRNA-100 and decreases the uptake of very low-density lipoprotein in endothelial cellsBritish journal of pharmacologyAugust 1, 2015Fang X, Fang L, Liu A, Wang X, Zhao B, Wang N.

(6) Development of telmisartan in the therapy of spinal cord injury: pre-clinical study in ratsDrug design, development and therapyJanuary 1, 2015Lin CM, Tsai JT, Chang CK, Cheng JT, Lin JW.

(7) Mechanisms of Nifedipine-Downregulated CD40L/sCD40L Signaling in Collagen Stimulated Human PlateletsPloS oneJanuary 1, 2015Chen TH, Shih CY, Hsu WL, Chou TC.

(8) Development of PPAR-agonist GW0742 as antidiabetic drug: study in animalsDrug design, development and therapyJanuary 1, 2015Niu HS, Ku PM, Niu CS, Cheng JT, Lee KS.

(9) Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated ReceptorsPloS oneJanuary 1, 2015Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart-Vogt E.

(10) RNA-seq identifies a role for the PPARβ/δ inverse agonist GSK0660 in the regulation of TNFα-induced cytokine signaling in retinal endothelial cellsMolecular visionJanuary 1, 2015Savage SR, McCollum GW, Yang R, Penn JS.

(11) An endoplasmic reticulum stress-initiated sphingolipid metabolite, ceramide-1-phosphate, regulates epithelial innate immunity by stimulating β-defensin productionMolecular and cellular biologyDecember 1, 2014Kim YI, Park K, Kim JY, Seo HS, Shin KO, Lee YM, Holleran WM, Elias PM, Uchida Y.

(12) Modulation of VEGF-induced retinal vascular permeability by peroxisome proliferator-activated receptor-β/δInvestigative ophthalmology & visual scienceNovember 18, 2014Suarez S, McCollum GW, Bretz CA, Yang R, Capozzi ME, Penn JS.

(13) The triggering receptor expressed on myeloid cells 2 inhibits complement component 1q effector mechanisms and exerts detrimental effects during pneumococcal pneumoniaPLoS pathogensJune 1, 2014Sharif O, Gawish R, Warszawska JM, Martins R, Lakovits K, Hladik A, Doninger B, Brunner J, Korosec A, Schwarzenbacher RE, et al.

(14) Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activityBritish journal of pharmacologyMarch 1, 2014Shih CY, Lin IH, Ding JC, Chen FC, Chou TC.

(15) Decrease of PPARδ in Type-1-Like Diabetic Rat for Higher Mortality after Spinal Cord InjuryPPAR researchJanuary 1, 2014Tsai CC, Lee KS, Chen SH, Chen LJ, Liu KF, Cheng JT.

(16) Merit of ginseng in the treatment of heart failure in type 1-like diabetic ratsBioMed research internationalJanuary 1, 2014Tsai CC, Chan P, Chen LJ, Chang CK, Liu Z, Lin JW.

(17) Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathyInvestigative ophthalmology & visual scienceJune 19, 2013Capozzi ME, McCollum GW, Savage SR, Penn JS.

(18) PPARβ/δ regulates glucocorticoid- and sepsis-induced FOXO1 activation and muscle wastingPloS oneJanuary 1, 2013Castillero E, Alamdari N, Aversa Z, Gurav A, Hasselgren PO.

(19) Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancerThe Journal of biological chemistryNovember 2, 2012Ramachandran L, Manu KA, Shanmugam MK, Li F, Siveen KS, Vali S, Kapoor S, Abbasi T, Surana R, Smoot DT, et al.

(20) Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supplyThe Journal of biological chemistryJuly 20, 2012Mottillo EP, Bloch AE, Leff T, Granneman JG.

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