Description
A CB2 receptor inverse agonist (Ki = 435 nM for recombinant human CB2); selective for CB2 over CB1 receptors (Ki = >20 µM); reduces basal production of inositol phosphate and increases forskolin-induced accumulation of cAMP in HEK293 cells expressing human CB2 receptors from 0.001-1 µM; inhibits LPS-induced NO and PGE2 production in J774 macrophages