Ionomycin from Cayman Chemical

Product Specs
ItemIonomycin
CompanyCayman Chemical
Price $54.00Supplier Page View Company Product Page
Catalog Number10004974
Quantity1 mg
FormatA 10 mg/ml solution in ethanol
Molecular Weight709
Purity≥95%
Research AreaAdaptive Immunity, Calcium Mobilization, Cell Biology, Cell Signaling, Immunology & Inflammation, Innate Immunity, NETosis
Storage-20
FormulaC41H72O9
OriginISR
Source/Expression SystemBacterium/Streptomyces conglobatus

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) LRRC8A Inhibition Overcomes Chemoresistance by Downregulating MRP3 and CYP3A4 in the 3D Spheroid Model of Human Breast Cancer CellsInt J Mol SciMarch 13, 2026Ryo Otsuka, Junko Kajikuri, Miki Matsui, Hiroaki Kito, Ayano Kitahara, Hinako Mitsui, Yohei Yamaguchi, Tomoka Hisada, Tatsuya Toyama, Susumu OhyaNJ, USA). AZD5363 (15406), GSK2795039 (33777), SCH772984 (19166), WNK-IN-11 (29676), and ionomycin (10004974) were from Cayman Chemical (Ann Arbor, MI, USA). ML385 (S8790), 666-15 (S8846), Ex527 (S1541) were from

(2) Lysosomal proteomics reveals mechanisms of neuronal APOE4-associated lysosomal dysfunctionAutophagyNovember 7, 2025Einar K. Krogsaeter, Justin McKetney, Leopoldo Valiente-Banuet, Angelica Marquez, Alexandra Willis, Zeynep Cakir, Erica Stevenson, Gwendolyn M. Jang, Antara Rao, Emmy Li, et al.treated with 200 µM GPN (Cayman Chemical, 14634) at 50 s, and with 4 µM ionomycin (Cayman Chemical, 10004974) at 150 s. At least three movies were captured for each technical replicate. Image analysis was performed

(3) A cell-based scrambling assay reveals the phospholipid headgroup preference of TMEM16F on the plasma membraneProceedings of the National Academy of SciencesNovember 4, 2025Chin Fen Teo, Sami T. Tuomivaara, Niek van Hilten, David Crottès, Yuh Nung Jan, Michael Grabe, Lily Y. Jan(100×stock), and stored at −20 °C as single-use aliquots. We purchased ionomycin from Cayman Chemical (cat# 10004974) supplied at 14.1 mM in ethanol, diluted it to 5 mM with 100% ethanol, and stored it at −20 °C as single-use

(4) Non-Ser36 phosphorylated p66Shc inhibits TRPC-dependent and TRPC-independent calcium influx in vascular smooth muscle cellsBiochemical and Biophysical Research CommunicationsNovember 1, 2025Perrin Schupbach, Bradley Miller, Andrey Sorokin- MedChemExpress (Monmouth, NJ); Oleoyl-acetyl-sn-glycerol (OAG, Item #62600), and Ionomycin (Item #10004974) - Cayman Chemical Company (Ann Arbor, MI); Endothelin-1 (ET-1, Cat #05–23-3800) - EMD-Millipore (Billerica,

(5) ENDOTHELIAL-SPECIFIC KNOCKOUT OF THE SCRAMBLASE TMEM16F IMPAIRS IN VIVO CLOT FORMATIONShockMay 1, 2025Grace Bonson, Aaron R. Lambert, Adrian M. Sackheim, Abigail J. Howard, Sophia H. Piffard, Carlos Lescieur-Garcia, Jade Cleary, Luisa Rubinelli, Annarita Di Lorenzo, Devdoot Majumdar, et al.Sigma-Aldrich #N3510), CaCCinh0-A01 (20μM Sigma-Aldrich # 208293), (and ionomycin (10μM; Cayman Chemical #10004974). Ionomycin was applied at the end of each experiment as a positive control to ensure capacity of calcium

(6) IL-1 protects from fatal systemic candidiasis in mice by inhibiting oxidative phosphorylation and hypoxiaNat CommunMarch 17, 2025Sofia Horn, Mareike Schmid, Ivan Berest, Federica Piattini, Jing Zhang, Katrien de Bock, Olivier Devuyst, Stellor Nlandu Khodo, Jan Kisielow, Manfred KopfPhorbol 12-myristate 13-acetate (PMA) (100 ng/mL, Sigma, P8139) and Ionomycin (1 µM, Cayman Chemical, 10004974), with 2 × 105 CFU C. albicans yeast, or with 2 × 105 CFU C. albicans yeast together with IL-1b (10

(7) Calmodulin enhances mTORC1 signaling by preventing TSC2-Rheb bindingJournal of Biological ChemistryFebruary 1, 2025Yuna Amemiya, Yuichiro Ioi, Makoto Araki, Kenji Kontani, Masatoshi Maki, Hideki Shibata, Terunao TakaharaSanta Cruz Biotechnology. BAPTA-AM solution (348-05451) was purchased from Wako. Calmidazolium (14442) and Ionomycin (10004974) were from Cayman Chemical, and W-7 hydrochloride (A2409) was from TCI. Hoechst 33342 (04929-82) was

(8) C646 degrades Exportin-1 to modulate p300 chromatin occupancy and functionCell Chemical BiologyJuly 18, 2024Yi Fan Chen, Atikur Rahman, Joel L. Sax, Matthew J. Atala Pleshinger, Ryan M. Friedrich, Drew J. Adams15217 Phorbol 12-myristate 13-acetate (PMA),Cayman Chemical,Cat# 10008014 Ionomycin,Cayman Chemical,Cat# 10004974 Biotin,Cayman Chemical,Cat# 22852 C646,MedChemExpress,Cat# HY-13823 Selinexor-Alkyne (See Data S1),Chen

(9) Ca2+-sensor ALG-2 engages ESCRTs to enhance lysosomal membrane resilience to osmotic stressProceedings of the National Academy of SciencesMay 28, 2024Wei Chen, Madeline M. Motsinger, Jiaqian Li, Kevin P. Bohannon, Phyllis I. HansonML-SA1 (No. 4746, Tocris Bioscience); 2.5 μM TG (AC328570010, Thermo Scientific); 5 μM Ionomycin (No. 10004974, Cayman Chemical); 250 μM CPZ (No. 16129, Cayman Chemical); 0.5 mg/mL Alexa Fluor 647 10,000 MW Dextran

(10) Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cellsNature communicationsMay 21, 2024Qiu F, Jiang P, Zhang G, An J, Ruan K, Lyu X, Zhou J, Sheng W.staining, cells were stimulated in RPMI 1640 culture medium with PMA (Cayman, 10008014), ionomycin (Cayman, 10004974), and Golgiplug (BD Pharmingen, 555029) for 4 h, and subjected to surface staining before being fixed

(11) Identification of compounds that cause axonal dieback without cytotoxicity in dorsal root ganglia explants and intervertebral disc cells with potential to treat pain via denervationPLOS ONEMay 2, 2024Fei San Lee, Uyen N. Nguyen, Eliza J. Munns, Rebecca A. WachsVcr stock solution was diluted to achieve 10 nM, 100 nM, 200 nM and 500 nM Vcr. Ionomycin (Cayman, 10004974, MW: 709 g/mol), supplied as 1 mg/mL in EtOH, was diluted directly in incomplete media to achieve 500

(12) Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediatorsCell Chemical BiologyDecember 1, 2023Lukas K. Peltner, Lars Gluthmann, Friedemann Börner, Simona Pace, Robert K. Hoffstetter, Christian Kretzer, Rosella Bilancia, Federica Pollastro, Andreas Koeberle, Giovanni Appendino, et al.GenPept: P05112 indomethacin,Cayman Chemical,Cat#70270; CAS: 53–86-1 ionomycin,Cayman Chemical,Cat#10004974; CAS: 56092–81-0 Lipofectamine™ LTX Reagent with PLUS™ Reagent,Invitrogen,Cat#15338030 lipopolysaccharide

(13) Targeting CaMKK2 Inhibits Actin Cytoskeletal Assembly to Suppress Cancer MetastasisCancer ResearchSeptember 1, 2023Debarati Mukherjee, Rebecca A. Previs, Corinne Haines, Muthana Al Abo, Patrick K. Juras, Kyle C. Strickland, Binita Chakraborty, Sandeep Artham, Regina S. Whitaker, Katherine Hebert, et al.GSKi) were synthesized at the Duke University Small Molecule Synthesis Facility. Ionomycin (catalog #10004974) was obtained from Cayman Chemicals and solubilized in DMSO at room temperature, sterile filtered (0.2

(14) Lysosome blockade induces divergent metabolic programs in macrophages and tumours for cancer immunotherapyJournal of experimental & clinical cancer research : CRAugust 4, 2023Ma J, Ma R, Zeng X, Zhang L, Liu J, Zhang W, Li T, Niu H, Bao G, Wang C, et al.calcium concentration by the Fluo-4 AM mean fluorescence intensity with ionomycin stimulated (Cayman, 10004974) on a real-time live-cell imaging with a high-speed laser confocal microscope. ICP-MS determination

(15) A genetically encoded sensor for visualizing leukotriene B4 gradients in vivoNat CommunAugust 1, 2023Szimonetta Xénia Tamás, Benoit Thomas Roux, Boldizsár Vámosi, Fabian Gregor Dehne, Anna Török, László Fazekas, Balázs Enyediperfused onto the cells using a custom-made perfusion system. Ionophores Ionomycin (Cayman Chemical, CAT#: 10004974; CAS: 56092-81-0) and A23187 (Sigma-Aldrich, CAT#: C9275; CAS: 52665-69-7) were directly added onto

(16) Reduced mitochondrial calcium uptake in macrophages is a major driver of inflammagingNat AgingJuly 1, 2023Seegren PV, Harper LR, Downs TK, Zhao XY, Viswanathan SB, Stremska ME, Olson RJ, Kennedy J, Ewald SE, Kumar P, et al.and concentrations used were: BAPTA-AM (Thermo Fisher, B6769; 10 µM), ionomycin (Cayman Chemicals, 10004974; 1 µM), BTP2 (Sigma, 203890-M; 10 µM), zegocractin (MedChemExpress, HY-101942; 1 µM) and AZD7545 (MedChemExpress,

(17) Annexin A6 mediates calcium-dependent exosome secretion during plasma membrane repaireLifeMay 19, 2023Justin Krish Williams, Jordan Matthew Ngo, Isabelle Madeline Lehman, Randy SchekmanOS,Other,N/A,Cell culture facility at UC Berkeley Chemical compound and drug,Ionomycin,Cayman Chemical,Catalog #: 10004974,See Materials and Methods for further details. Recombinant DNA reagent,pLKO.1_Hygro GFP shRNA,This

(18) A photocaged orexin-B for spatiotemporally precise control of orexin signalingCell Chemical BiologyDecember 15, 2022Loïc Duffet, Petr V. Tatarskiy, Masaya Harada, Elyse T. Williams, Nina Hartrampf, Tommaso Patriarchi1-28 aa.)",Sigma-Aldrich Chemie GmbH,Cat# SCP0204Lot:E278025 Ionomycin,Cayman Chemical Company,Cat#10004974 PfuUltra II Hotstart PCR Master Mix,Agilent technologies,Cat#600850 NEBuilder® HiFi DNA Assembly Cloning Kit

(19) TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1Frontiers in immunologyJanuary 1, 2022Akagi T, Hiramatsu-Asano S, Ikeda K, Hirano H, Tsuji S, Yahagi A, Iseki M, Matsuyama M, Mak TW, Nakano K, et al.12-myristate 13-acetate (PMA; AG-CN2-0010, AdipoGen Life Sciences, San Diego, CA, USA), ionomycin (10004974, Cayman Chemical, Ann Arbor, MI, USA), cycloheximide (CHX; 0970, Bio-Techne, Minneapolis, MN, USA),

(20) Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during agingThe Journal of clinical investigationJanuary 4, 2021Propson NE, Roy ER, Litvinchuk A, Köhl J, Zheng H.R&D Systems, 3677-C3-025), C5a (250 nM, R&D Systems, 2037-C5-025), ionomycin (10 μM, Cayman Chemical, 10004974), or in combination with one of the inhibitors SB290157 (5 μM, Calbiochem, 559410), W7 (50 μM, Tocris,

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Ionomycin

Ionomycin

Ionomycin from Cayman Chemical

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Cayman Chemical

Citations (27)

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Ionomycin from Cayman Chemical

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