2-NBDG from Cayman Chemical

Product Specs
Item2-NBDG
CompanyCayman Chemical
Price $198.00Supplier Page View Company Product Page
Catalog Number11046
Quantity10 mg
Research AreaCancer, Diabetes, Endocrinology & Metabolism, Metabolic Diseases, Metabolism
FormatA crystalline solid
Molecular Weight342.3
Purity≥98% (mixture of α and β)
OriginUSA
FormulaC12H14N4O8
Storage-20

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) SPNS2 exports sphingosine-1-phosphate and imports glucoseNat CommunApril 20, 2026Cynthia Weigel, Md Lokman Hossen, Ryan D. R. Brown, Can E. Senkal, Christopher D. Green, Jason Newton, Sumit Saha, Elisa N. D. Palladino, Bin Ni, Francesco S. Celi, et al.min with 200 µg/ml of 2NBD-glucose, 2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (#11046, Cayman Chemical Company), a fluorescently-labeled deoxy-glucose analog, washed and fluorescent signals

(2) Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activityCell ReportsMarch 24, 2026Prabhakar Arumugam, Cortney E. Heim, Rachel W. Fallet, Dhananjay D. Shinde, Vinai C. Thomas, Rafael J. Argüello, Tammy KielianZombie UV Fixable Viability Kit,BioLegend,423108 Zombie NIR Fixable Viability Kit,BioLegend,423106 2-NBDG,Cayman Chemical,11046 Mitotracker Green FM,Cell Signaling Technology,9074S MitoSOX,Invitrogen,M36008 MitoPY1,Tocris,4428 MitoTracker Deep Red FM

(3) KRAS-dependent glycolytic reprogramming of endothelial cells in sporadic arteriovenous malformationsEMBO Molecular MedicineFebruary 18, 2026Ruilin Wu, Negar Khosraviani, Ann Mansur, Emilie Boudreau, Gabrielle E Largoza, Suejean Park, Dakota Gustafson, Sneha Raju, Crizza Ching, Amira Klip, et al.starvation. Following starvation, cells were incubated with 150 μM of 2-NBDG (Cayman Chemical, Cat #: 11046) in glucose-free media for 1 h in the incubator. After incubation, Hoechst dye was added to stain the

(4) Aporocactus flagelliformis water extract and limonin suppresses P2Y purinoceptor 14-mediated proinflammatory features in 3D4/31 porcine alveolar macrophagesJournal of Animal Science and TechnologyJanuary 31, 2026Hyungkuen Kim, Hyun Sik Jun, Ki-Duk Song Song, Sung-Jo Kimflow cytometry. Glucose uptake assay Cells were suspended in PBS containing 50 µM 2-NBD-glucose (2-NBDG; 11046-10MG, Cayman Chemical) and 0.1% (w/v) BSA, incubated for 30 min, washed with PBS, and analyzed by flow cytometry

(5) Acetyl-CoA availability regulates neuronal metabolism, growth, and synaptic activitybioRxivJanuary 24, 2026Eric R. McGregor, Cassandra J. McGill, Nicholas L. Arp, Josef P. Clark, Dominique A. Baldwin, Di Kuang, Gonzalo Fernandez-Fuente, Yun Hwa Choi, Keenan S. Pearson, Jason K. Nagorski, et al.http://rsb.info.nih.gov/ij/). Glycogen labeling: Neurons were incubated for 6 hours with 500 μM 2-NBDG (11046; Cayman Chemical Company; Ann Arbor, MI, USA). Neurons were then washed three times with PBS before

(6) IL-18 metabolically reprograms CAR-expressing natural killer T cells and enhances their antitumor activityMolecular TherapyJanuary 10, 2026Gabriel A. Barragán Barragán Bravo, David A. de la Cerda, Elisa Landoni, Kshiti Dholakia, Piotr Humeniuk, Leidy D. Caraballo Caraballo Galva, Ying Wang, Gengwen Tian, Boning Yang, Linjie Guo, et al.Gibco) and incubated for 30 minutes at 37C, after which cells were stained with 2-NBDG (Cayman chemical, 11046) at a final concentration of 50 μM. To assess fatty acid uptake, NKTs were washed in DPBS and resuspended

(7) Glycolysis maintains effector function of lung Th17 TRM cells in precision cut lung slicesiScienceDecember 19, 2025Haoran Yang, Vaishnavi R. Kumaran, Kejing Song, T. Parks Remcho, Robert D.E. Clark, Sharad Thakur, Shiping Lu, Mark A.A. Harrison, Naoki Iwanaga, Maria de la Luz Garcia-Hernandez, et al.700-100P Phorbol 12-myristate 13-acetate,Sigma,Cat# P8139 Ionomycin,Sigma,Cat#I0634 2-NBDG,Cayman,Cat#11046-10mg 2-DG,Selleckchem,Cat# S4701 Oligomycin A,Selleckchem,Cat# S1478 DFMO,Selleckchem,Cat# S4582 PBS

(8) BNIP3 is a key driver of breast cancer progression and a novel glycolysis-regulating biomarkerSci RepDecember 10, 2025Lichen Cao, Minjing Yu, Guipu Zhang, Lingyu Xu, Jie Shi, Haiyan Gaowith serum-free medium containing 100 µM of the fluorescent glucose analog 2-NBDG (Cayman Chemical, #11046). Following incubation, the cells were washed twice with PBS to remove excess 2-NBDG. The fluorescence

(9) Glycogen phase-separation drives macromolecular rearrangement and asymmetric division in E. coliThe EMBO JournalNovember 3, 2025Yashna Thappeta, Silvia J Cañas-Duarte, Haozhen Wang, Till Kallem, Alessio Fragasso, Yingjie Xiang, William Gray, Cheyenne Lee, Georgeos Hardo, Lynette Cegelski, et al.,Fisher Scientific,BP1760-25 Kanamycin,Sigma-Aldrich,K1377-25G Chloramphenicol,Sigma-Aldrich,C0378-25G "4′,6-diamidino-2-phenylindole (DAPI)",ThermoFisher,D1306 2-NBDG,Cayman Chemical Company,11046 MitoTracker Green,ThermoFisher,M7514 SYTO RNASelect,ThermoFisher,S32703 Cephalexin,Sigma-Aldrich,C4895 PEG1500,Sigma-Aldrich,81210-500

(10) Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226(+) B cells in type 1 diabetesEBioMedicineOctober 1, 2025Li J, Liang X, Zhao M, Luo W, Huang J, Xiao Y, Huang J, Zhao B, Zhou Z.medium with 100 μM 2-NBDG (2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose, Cayman, Cat#11046) for 30 min in a 37 °C incubator. For fatty acid (FA) uptake detection, the cells were performed in

(11) A genome-wide, CRISPR-based screen reveals new requirements for translation initiation and ubiquitination in driving adipogenic fate changeGenes & DevelopmentOctober 1, 2025Rachel E. Turn, Keren I. Hilgendorf, Carl T. Johnson, Kyuho Han, Mohammad Ovais Aziz-Zanjani, Samuel Swails Bollinger, Pablo Domizi, Ran Cheng, Atefeh Rabiee, Yingdi Zhu, et al.10 µM NAE inhibitor MLN4924 for the indicated time periods in the presence of 100 µM 2-NBDG (Cayman 11046) or ethanol control. Cells were imaged using the IncuCyte live-cell analysis imaging system (Essen BioScience)

(12) Periosteal skeletal stem cells can migrate into the bone marrow and support hematopoiesis after injuryElifeMay 22, 2025Tony Marchand, Kemi E Akinnola, Shoichiro Takeishi, Maria Maryanovich, Sandra Pinho, Julien Saint-Vanne, Alexander Birbrair, Thierry Lamy, Karin Tarte, Paul S Frenette, et al.Supplement,StemCell Technologies,Catalog #: 05402, Chemical compound,2-NDBG,Cayman Chemical Company,Catalog #: 11046, Chemical compound,SCEM embedding media,Section-lab,"Kawamoto and Shimizu, 2000", Chemical Compound,StemXVivo Osteogenic/Adipogenic Base media

(13) The role of PKM2-mediated metabolic reprogramming in the osteogenic differentiation of BMSCs under diabetic periodontitis conditionsStem Cell Res TherApril 18, 2025Yanlin Zhu, Yuhan Yang, Yuyan Lan, Zun Yang, Xiang Gao, Jie Zhouincubated in the dark at 37 °C with 2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG, 11046, Cayman, USA) at a working concentration of 200 µM for 30 min. The uptake of glucose was analyzed using

(14) Combining evidence from human genetic and functional screens to identify pathways altering obesity and fat distributionmedRxiv : the preprint server for health sciencesMarch 14, 2025Baya NA, Erdem IS, Venkatesh SS, Reibe S, Charles PD, Navarro-Guerrero E, Hill B, Lassen FH, Claussnitzer M, Palmer DS, et al.assay Undifferentiated and differentiated hWAT and single-gene KO cells were stained with 2-NBD-Glucose (Cayman Cat# 11046) for 1 hour. After 1 hour, Hoechst (Hoechst 33342, Trihydrochloride, Trihydrate −10mg/mL solution in

(15) Shear stress-stimulated AMPK couples endothelial cell mechanics, metabolism and vasodilationJournal of cell scienceDecember 15, 2024Cronin NM, Dawson LW, DeMali KA.uptake assay Glucose uptake was assessed by measuring the fluorescence of 2-NBDG (Cayman Chemicals 11046). Cells were grown to confluency. Cells were pretreated with inhibitors or function-blocking antibodies

(16) A peptide derived from the amino terminus of leptin improves glucose metabolism and energy homeostasis in myotubes and db/db miceJournal of Biological ChemistryDecember 1, 2024Mehmood Ali, Arvind Gupta, Rahul Dev Verma, Sariyah Akhtar, Jimut Kanti GhoshThermo Fisher Scientific. 2-(7-Nitrobenz-2- oxa-1, 3-diazol-4-yl) amino-2-deoxy-D-glucose (2NBDG) (11046), wortmannin (10010591), AKTi (14870), indinavir and dorsomorphin (11967) from Cayman. Protease inhibitor

(17) Advanced glycation end-products accelerate amyloid deposits in adipocyte's lipid dropletsCell death & diseaseNovember 19, 2024Izgilov R, Kislev N, Omari E, Benayahu D.fluorescent glucose analog, 2-NBDG (2-Deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl) amino]-D-glucose) (11046, Cayman chemical). Cultured 3T3-L1 cells “starved” in a glucose-free medium at 37 °C for 1 h, then added

(18) Pinus koraiensis essential oil enhances glucose uptake and proliferation in SH-SY5Y neuroblastoma cellsScientific ReportsNovember 4, 2024Hyungkuen Kim, Hwan Myung Lee, Sung-Jo KimUSA). Final concentration at 1 µM of H2DCFDA (35845, Sigma-Aldrich, St. Louis, MO, USA), 50 µM 2-NBDG (11046-10MG, Cayman Chemical, Ann Arbor, MI, USA), 50 nM MTDR (M22426, Invitrogen, Carlsbad, CA, USA), 10 µM

(19) The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial functionImmunityAugust 1, 2024Christopher M. Jackson, Ayush Pant, Wikum Dinalankara, John Choi, Aanchal Jain, Ryan Nitta, Eli Yazigi, Laura Saleh, Liang Zhao, Thomas R. Nirschl, et al.,Thermo Fisher Scientific,Cat#M7514 "2-deoxy-2-[(7-nitro-2,1,3-benzoxadiazol-4-yl)amino]-D-glucose (2-NBDG)",Cayman Chemical,Cat#11046 PolyVivo AK109 PLCL-PEG-PLCL hydrogel,PolySciTech,Lot#:171025SLG-A alamarBlue Cell Viability Reagent,Thermo Fisher Scientific

(20) Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunityImmunityAugust 1, 2024Rebecca B. Delconte, Mark Owyong, Endi K. Santosa, Katja Srpan, Sam Sheppard, Tomi J. McGuire, Aamna Abbasi, Carlos Diaz-Salazar, Jerold Chun, Inez Rogatsky, et al.Protein Transport Inhibitor (containing Brefeldin A),BD Biosciences,Cat#555029 Dexamethasone,Sigma-Aldrich,Cat#D1756 2-NBDG,Cayman,Cat#11046 BODIPY 493/503,Thermofisher,Cat#D3922 BODIPY FL C16,Thermofisher,Cat#D3822 Percoll,GE Healthcare,Cat#17-0891-01 Critical

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2-NBDG from Cayman Chemical

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Cayman Chemical

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2-NBDG from Cayman Chemical

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