DAPT from Selleck Chemicals

Product Specs
ItemDAPT
CompanySelleck Chemicals
Price $297.00Supplier Page View Company Product Page
Catalog NumberS2215
Quantity25mg
Purity99.18
TargetGamma-secretase
Molecular Weight546.88
Storage2 years -80 in solvent
FormulaC23H26F2N2O4

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Selleck Chemicals

14408 W Sylvanfield Drive

Houston, Texas TX 77014

United States

Phone: Toll Free: (877) 796-6397 (US and Canada only)
Tel: (832) 582-8158
Fax: (832) 582-8590

Email: sales@selleckchem.com

Company Profile

Website: www.selleckchem.com

(1) Activation of the G-protein coupled estrogen receptor 1 (GPER1) reduces transient receptor potential vanilloid 1 (TRPV1) activity and human iPSC-derived nociceptive neuron firingStem Cell Res TherJuly 7, 2026Oliver Dräger, Angelique Grell, Asaria E. Vogel, Erhard Wischmeyer, Beatrice A. Nossekwith SU5402 (10 µM, # S7667, Selleckchem, Houston, TX, USA) and Notch signaling with DAPT (10 µM, # S2215, Selleckchem, Houston, TX, USA) followed for day 2 to day 12. Additionally, KSR medium was incremented

(2) CRISPR activation of DLX5 drives neural progenitors to the GnRH cell fateJ Mol EndocrinolJuly 1, 2026Shrinidhi Madhusudan, Nazli Eskici, Celia Gomez-Sanchez, Kristiina Pulli, Kirsi Vaaralahti, Venkatram Yellapragada, James R W Conway, Yafei Wang, Taneli Raiviodays 21 to 25, NPCs were treated with 20 μM of the Notch signaling inhibitor DAPT (Selleckchem, Cat. S2215) and the medium was refreshed every other day. Neurons were collected in cold PBS for downstream analysis. CRISPR activation

(3) Kdm6b-mediated epigenetic coordination of temporal precision during motor neuron differentiationEMBO ReportsMay 26, 2026Haihan Ren, Qicheng Liu, Bingqian Li, Xuetong Yu, Dan Liang, Shuangling Li, Bing Pan, Qian Gao, Wenhong Deng, Jun-Ma Yu, et al.(RA),Sigma-Aldrich,R2625 Smoothened Agonist (SAG),Selleck Chemicals,S7779 DAPT,Selleck Chemicals,S2215 GSKJ4,Selleck Chemicals,S7070 Hyperactive pG-MNase Cut&Run Assay Kit for Illumina,Vazyme,HD102 Hyperactive

(4) RBFOX1 Dysfunction Unlocks APOE4-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral OrganoidsExploration (Beijing)April 2, 2026Bowen Zhang, Changjie Shi, Jiayi Zhao, Qiuhong Hua, Houchun Zhang, Hailin Gao, Yuanyuan Qian, Jiaxue Cha, Jing Li, Jiayao Chen, et al.µM), PD0325901 (0.4 µM) (Selleck, S1036), SU5402 (2 µM) (Selleck, S7667), and DAPT (5 µM) (Selleck, S2215) (LSB + X + P/S/D) were added into the 6‐well plate. Day 5‐Day 7: N2/B27 medium was added to E6 at 1/3

(5) Rapid expansion of primary human vocal fold epithelial cells via targeted pathway inhibition and anchorage-independent sphere cultureCell Rep MethodsMarch 23, 2026Xudong Shi, Ryo Suzuki, Haiyan Lu, Hua Zhang, Lingjun Li, Nathan V. WelhamCAS: 909910-43-6 Y-27632,Selleck Chemicals,Cat# S1049; CAS: 129830-38-2 DAPT,Selleck Chemicals,Cat# S2215; CAS: 208255-80-5 Type I collagenase,Sigma Aldrich,Cat# C0130; CAS: 9001-12-1 "Type I collagen, rat

(6) Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulationJournal of Translational MedicineMarch 13, 2026Shunjie Qing, Yunyan Ling, Yingjie Lai, Yating Hu, Yi Zhong, Yuechen Liu, Xiang Liu, Yuan Fang, Junying Qian, Haijun Deng, et al.deplete CD8+ T cells. In certain experiments, mice were intraperitoneally injected with DAPT (Selleck, S2215, 20 mg/kg, administered every other day) to suppress the NOTCH1 signaling pathway. In certain experiments,

(7) Cellular and Extracellular MicroRNA Dysregulation in LRRK2-Linked Parkinson’s DiseaseMolecular NeurobiologyJanuary 1, 2026Felix Knab, Jun-Hoe Lee, Raja Nirujogi, Kevin Menden, Luca Braunger, Lambrianna Logarnudi, Benjamin Riebenbauer, Fatma Busra Isik, Anto Praveen Rajkumar, Stefan Czemmel, et al.(PanReac AppliChem (Darmstadt, Germany), #A0455), and 10 µM DAPT (Selleckchem (Houston, TX, USA), #S2215) for the remainder of the differentiation (days 8 to 23). None of the used media contained fetal calf

(8) Antibody-induced internalization and degradation of PLA2R amplifies CD4+ T cell activationTheranosticsJanuary 1, 2026Yuning Liu, Yinyin Li, Hui Zhou, Jieli Yu, Pei Deng, Weiwei Xu, Bingqian Pan, Lei Zhang, Hong Zhou, Jing Zhang, et al.from New England Biolabs; Bafilomycin A1 (Baf-A1, S1413, 200 nM), GI254023X (GI, S8660, 550 nM), DAPT (S2215, 10 μM) and Batimastat (BB-94, S7155, 1 μM) were purchased from Selleck Chemicals; Cocktail (HY-K0010),

(9) EpCAM activates the ERK-EGR1 signaling axis and promotes TNF-α-induced the progression of anaplastic thyroid cancerJournal of Translational MedicineDecember 22, 2025Chi-Chiu Lee, Yi-Jen Su, Sushree Shankar Panda, Chiung-Yi Chiu, Chung-Hsuan Wu, Tsai-Ming Lu, Pi-Chun Li, Yen-Lin Huang, Ruey-Long Hong, Shao-Hsi Hung, et al.Dabrafenib (HY-14660) was obtained from Med Chem Express (MCE). TAPI (metalloproteinase inhibitor) (S2215) and DAPT (γ-secretase inhibitor) (E7213) were obtained from Selleckchem. Cell lines and culture ATC

(10) Disruption of Krox20-Notch1 signaling blocks meibomian gland development and homeostasis leading to dry eye diseaseNature CommunicationsNovember 23, 2025Yumeng Zhang, Edem Tchegnon, Elnaz Ghotbi, Zhiguo Chen, Stefanie L. Moye, Yi He, Renée M. McKay, Lu Q. Le66-hours post-transduction via RT-qPCR, bulk RNA-Seq, and western blot. For DAPT treatment, 10 μM DAPT (S2215, Selleckchem) alone or combined with pLenti-KROX20 was added to the culture medium of IHMGECs and the

(11) Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8 + T‐Cell‐Driven Cancer Cell PyroptosisAdvanced ScienceNovember 21, 2025Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, et al.DAPT (N‐[N‐(3,5‐difluorophenacetly L‐alanyl)]‐S‐phenylglycinet‐butyl ester, GSI‐IX) (Selleck, Cat. no. S2215‐30 mg‐lsx) was diluted in DMSO (4%) (Sigma, Cat. no. D2650‐100ML) and corn oil (96%) (Selleck, S6701‐100

(12) Alpha hemolysin enhances the immune response by modulating dendritic cell differentiation via ADAM10-Notch signalingSignal Transduct Target TherOctober 8, 2025Ke Wang, Jingwen Liao, Yue Yuan, Zhifu Chen, Qiang Gou, Haiming Jing, Mengmeng Liang, Yuanda Tang, Pengju Yan, Xiaoqian Yu, et al.intraperitoneally (100 mg/kg) or treat BMDCs (20 μM/1 × 106 cells). The Notch inhibitor DAPT (Selleck, Cat# S2215) was used to treat BMDCs (20 μM/1 × 106 cells). BMDCs were pretreated with GI254023X and DAPT (NICD

(13) Geometrically-engineered human motor assembloids-on-a-chip for neuromuscular interaction readout and hypoxia-driven disease modelingNature CommunicationsSeptember 30, 2025Weihua Zhang, Liming Yu, Jie Pan, Jiajia Deng, Xianqin Tong, Bingjiao Zhao, Wen Liu, Liangyan Sun, Menghan Zhang, Xinxin Han, et al.onward, neural medium was supplemented with 0.5 μM RA and 0.1 μM Purmorphamine, 5 μM DAPT (Selleck, S2215), 20 ng/mL BDNF (Peprotech, 450-02) and 20 ng/mL GDNF (Peprotech, 450-10) every other day. A schematic

(14) Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorderExperimental & Molecular MedicineAugust 15, 2025Jongpil Shin, Hyeonsik Oh, Ji Hye Park, Hyunsik Bae, Chan Mo Yang, Minju Lee, Seokhwi Kim, Won Do Heostimulation. N-[N-(3,5-difluorophenacetyl)-l-alanyl]-S-phenylglycine t-butyl ester (DAPT) (Selleckchem, cat. no. S2215) was similarly prepared and administered intraperitoneally (100 mg kg−1) 12 h before blue light stimulation

(15) Mapping multimodal phenotypes to perturbations in cells and tissue with CRISPRmapNature biotechnologyJuly 1, 2025Gu J, Iyer A, Wesley B, Taglialatela A, Leuzzi G, Hangai S, Decker A, Gu R, Klickstein N, Shuai Y, et al.replaced and supplemented with RA (100 nM), SAG (500 nM), BDNF (10 ng ml−1) and DAPT (10 µM, Selleckchem, S2215). On day 11, media were replaced and supplemented as on day 9. On day 14, media were replaced and supplemented

(16) Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularizationScienceJune 5, 2025Oscar J. Abilez, Huaxiao Yang, Yuan Guan, Mengcheng Shen, Zehra Yildirim, Yan Zhuge, Ravichandra Venkateshappa, Shane R. Zhao, Angello H. Gomez, Marcel El-Mokahal, et al.lumen. Signaling pathway inhibition For NOTCH signaling pathway inhibition we used 0, 1, and 10 μM DAPT (GSI-IX) (S2215, Selleck Chemicals) added at day 0 of differentiation. For BMP signaling pathway inhibition, we used

(17) Requirements for the neurodevelopmental disorder-associated gene ZNF292 in human cortical interneuron development and functionCell ReportsMay 27, 2025Komal Kaushik, Gareth Chapman, Ramachandran Prakasam, Faiza Batool, Maamoon Saleh, Julianna Determan, James E. Huettner, Kristen L. Krollproteins" SB431542,Selleckchem,S1067 SAG,Selleckchem,S6384 LDN193189,Tocris Biosciences,6053/10 XAV939,Selleckchem,S1180 Y27632,Selleckchem,S6390 DAPT,Selleckchem,S2215 Ascorbic Acid,Sigma Aldrich,A5960 Dibutyryl cAMP sodium salt,Sigma Aldrich,D0260 BDNF,Peprotech,450–02 Crystal violet

(18) Transfer RNA-derived fragment tRF-36 modulates varicose vein progression via human vascular smooth muscle cell Notch signalingOpen Life SciApril 24, 2025Guojun Chen, Chong Yu, Yu Shi, Danna Cai, Bin Zhouγ-secretase inhibitor GSI-IX (DAPT) (Notch signaling pathway inhibitor; Selleck, Houston, TX, USA; # S2215), different concentrations of DAPT (0, 2.5, 5, 10, or 20 μM) were used to treat the HVSMCs with 0 μM

(19) The Molecular and Clinical Impact of Atorvastatin Exposure on Paclitaxel Neurotoxicity in Sensory Neurons and Cancer PatientsBasic Clin Pharmacol ToxicolMarch 27, 2025Emma Simonsen, Christina Mortensen, Cathrine Lundgaard Riis, Karina Dahl Steffensen, Morten Olesen, Martin Thomsen Ernst, Tore Bjerregaard Stage, Anton Pottegårdmolecule inhibitors LDN193189 (S7507), SB431542 (S1067), CHIR99021 (S1263), SU5402 (S7667) and DAPT (S2215) were purchased from Selleck Chemicals (Houston, TX, USA). The neurotrophic growth factors NGF‐β (450‐01),

(20) Innate immune sensing of rotavirus by intestinal epithelial cells leads to diarrheaCell Host & MicrobeMarch 12, 2025Gaopeng Hou, Juhee Son, Maria Florencia Gomez Gomez Castro, Takahiro Kawagishi, Xingxing Ren, Alexa N. Roth, Avan Antia, Qiru Zeng, Anna L. DeVeaux, Ningguo Feng, et al.nM Gastrin (Sigma-Aldrich #G9145), 0.5 μM A83–01 (Sigma-Aldrich #SML0788), 500 nM DAPT (Selleckchem #S2215), 50 ng/ml mouse EGF (R&D #2028-EG) for 2 days and stimulated with 10 μg/ml mouse IFN-λ for 24 hours.

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DAPT

DAPT from Selleck Chemicals

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Selleck Chemicals

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DAPT from Selleck Chemicals

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