Ac-YVAD-CMK from Cayman Chemical

Product Specs
ItemAc-YVAD-CMK
CompanyCayman Chemical
Price $42.00Supplier Page View Company Product Page
Catalog Number10014
Quantity500 µg
Research AreaBehavioral Neuroscience, Cell Biology, Cell Death, Cytosolic & Secreted Proteases, Neuroscience, Proteolysis, Pyroptosis, Sleep & Biological Rhythms
FormatA crystalline solid
Molecular Weight541
Purity≥98%
Storage-20
FormulaC24H33ClN4O8
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Mycobacterium tuberculosis, Mycobacterium kansasii and Rhodococcus equi induce macrophage necroptosis in the presence of a caspase inhibitor acting on a non-canonical target(s)bioRxivSeptember 11, 2025Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi-Nan Gong, Carl F. Nathan, et al.(#FMK007) were from Fisher Scientific. Necrosulfonamide (#20844), Q-VD-OPH (#15260) and Ac-YVAD-CMK (#10014) were from Cayman Chemical. Mouse monoclonal anti-human IFN-γ Rα chain (as control IgG; #G737) and mouse

(2) Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticusActa Neuropathol CommunApril 10, 2025Lihan Liu, Yue Wang, Xiaolin Wang, Guowen Zhang, Sha Sha, Rong Zhou, Yimei Du, Chunfeng Wu, Lei Chen(cat. no. 14487), ethylscopolamine (cat. no. 23862), ketamine (cat. no. 11630), Ac-YVAD-cmk (cat. no. 10014), and xylazine (cat. no. 14113) were obtained from Cayman Chemical Company (Ann Arbor, MI, USA). Unless

(3) Non-canonical inflammasome activation mediates the adjuvanticity of nanoparticlesCell reports. MedicineJanuary 17, 2023Muñoz-Wolf N, Ward RW, Hearnden CH, Sharp FA, Geoghegan J, O'Grady K, McEntee CP, Shanahan KA, Guy C, Bowie AG, et al.GmbH,LET0027 Necrosulfomide (NSA),Millipore,480073 Dimethylfumarate (DMF),Sigma,50744 Ac-YVAD-cmk,Cayman Chemical,10014 Influenza nucleoprotein peptide NP311-325 (QVYSLIRPNENPAHK),JPT Peptide Technologies,12489 Maleimide-activated

(4) Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal DysfunctionThe Journal of ImmunologyOctober 1, 2022Xiaohua Peng, Jooyoung Kim, Gayatri Gupta, Karen Agaronyan, Madeleine C. Mankowski, Asawari Korde, Shervin S. Takyar, Hyeon Jun Shin, Victoria Habet, Sarah Voth, et al.purchased from ApexBio (Cat# A8239). Caspase-1 inhibitor Ac-YVAD-CMK was purchased from Cayman (Cat# 10014). Latex beads were purchased from Polysciences.com (Cat#17458–10). LysoTracker™ Red DND-99 was purchased

(5) Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosisCellAugust 18, 2022Weindel CG, Martinez EL, Zhao X, Mabry CJ, Bell SL, Vail KJ, Coleman AK, VanPortfliet JJ, Zhao B, Wagner AR, et al.naked,InvivoGen,tlrl-patn-1 CL097,InvivoGen,tlrl-c97 LPS,InvivoGen,tlrl-pb5lps cGAMP,InvivoGen,tlrl-nacga23-02 Pam3CSK4,InvivoGen,tlrl-pms ISD,Watson lab, AC-YVAD-CMK,InvivoGen,10014 Dapansutrile,Cayman Chemicals,24671 GNE9605,Cayman Chemicals,23446 Z-IETD-FMK,BD biosciences,550380 necrostatin-1

(6) Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell ProductionDevelopmental cellOctober 26, 2020Frame JM, Kubaczka C, Long TL, Esain V, Soto RA, Hachimi M, Jing R, Shwartz A, Goessling W, Daley GQ, et al.tlrl-alk Nigericin,Cayman Chemical,Cat# 11437 Metronidazole,Millipore Sigma,Cat# M3761 Ac-YVAD-CMK,Cayman Chemical,Cat#10014 LPS,Invivogen,Cat# tlrl-eklps CHIR99021,Stem Cell Technologies,Cat# 72052 SB431542,Stem Cell Technologies,Cat#

(7) Antitumor Effects of Berberine on Gliomas via Inactivation of Caspase-1-Mediated IL-1β and IL-18 ReleaseFrontiers in oncologyJanuary 1, 2019Tong L, Xie C, Wei Y, Qu Y, Liang H, Zhang Y, Xu T, Qian X, Qiu H, Deng H.U251 cells were treated with a specific caspase-1 inhibitor N-Ac-Tyr-Val-Ala-Asp-CMK (Ac-YYAD-CMK) (10014; Cayman Chemical, Ann Arbor, MI, USA) and U0216, a MEK1 and MEK2 inhibitor (U120; Sigma-Aldrich, St.

(8) 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathwayAutophagyNovember 2, 2018Yasuomi Urano, Chinatsu Mori, Ayano Fuji, Keito Konno, Takayuki Yamamoto, Shohei Yashirogi, Mayu Ando, Yoshiro Saito, Noriko NoguchiZ-VAD(OMe)-FMK (zVAD; 269–02071) were from Wako. Brefeldin A (203729) was from Merck. Ac-YVAD-CMK (YVAD; 10014) was from Cayman Chemical Company. Rapamycin (S1039) was obtained from Selleck Chemicals. The following

(9) Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axisThe EMBO journalSeptember 14, 2018Zheng Y, Liu Q, Wu Y, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP, Cui J.carfilzomib were purchased from ApexBio. ATP and poly(I:C) (LMW) were purchased from Invivogen. Ac-YVADcmk (10014) was purchased from Cayman Chemical Company. A/G beads. For immunoprecipitation with anti-Flag or anti-HA,

(10) Pyroptosis, a novel mechanism implicated in cataractsMolecular Medicine ReportsJune 19, 2018Xin Jin, Hao Jin, Yan Shi, Yiyuan Guo, Hong Zhangalone. Caspase‑1 inhibitor for downregulation was synthesized by Cayman Chemical Company (item no. 10014; Ann Arbor, MI, USA). After the cell density reached 80%, 100 µM caspase‑1 inhibitor was added simultaneously

(11) Mitochondrial DNA-enriched microparticles promote acute-on-chronic alcoholic neutrophilia and hepatotoxicityJCI insightJuly 20, 2017Cai Y, Xu MJ, Koritzinsky EH, Zhou Z, Wang W, Cao H, Yuen PS, Ross RA, Star RA, Liangpunsakul S, et al.mg/kg) (EMD Millipore) by i.m. injection, and caspase-1 inhibitor Ac-YVADcmk (Cayman Chemical, catalog 10014) by i.p. injection approximately 15 minutes before oral gavage. insight.jci.org https://doi.org/10.1172/jci.insight.92634 11 RESEARCH

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Ac-YVAD-CMK from Cayman Chemical

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Cayman Chemical

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Ac-YVAD-CMK from Cayman Chemical

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