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Protein Biochemistry
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A-922500
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A-922500
A-922500
A-922500 from Cayman Chemical
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Citations:
(6)
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Supplier Page from
Cayman Chemical for
A-922500
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Description
A potent inhibitor of DGAT-1 (IC50s = 7 and 24 nM, for human and mouse, respectively); confers significant weight loss within seven days and significantly reduces plasma and liver triglycerides when administered at 3 mg/kg to DIO mice
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
A-922500
Company
Cayman Chemical
Price
$42.00
Supplier Page
View Company Product Page
Catalog Number
10012708
Quantity
1 mg
Research Area
Dyslipidemias, Endocrinology & Metabolism, Metabolic Diseases, Obesity
Format
A crystalline solid
Molecular Weight
428.5
Purity
≥95%
Storage
-20
Formula
C26H24N2O4
Origin
USA
Type
Inhibitors
Add to Compare List
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (6)
(1)
Defective lipid droplet biogenesis exacerbates oleic acid-induced cellular homeostasis disruption and ferroptosis in mouse cardiac endothelial cells
Cell Death Discov
August 9, 2025
Yun-Ting Wang, Alexandra K. Moura, Rui Zuo, Zhengchao Wang, Kiana Roudbari, Jenny Z. Hu, Mi Wang, Pin-Lan Li, Yang Zhang, Xiang Li
(
Cayman Chemical
19288
),
PKUMDL-LC-101-D04
(PKUMDL) (
Cayman Chemical
28966
),
A-922500
(DGAT1i) (
Cayman Chemical
10012708
),
PF-06424439
(DGAT2i) (
Cayman Chemical
17680
),
siLentFect™ Lipid Reagent for RNAi
(
Bio-Rad
1703362
),
(2)
HSV-1 alters lipid metabolism and induces lipid droplet accumulation in functionally impaired mouse dendritic cells
iScience
May 16, 2025
Mónica A. Farías, Felipe A. Cancino, Areli J. Navarro, Luisa F. Duarte, Abel A. Soto, Eduardo I. Tognarelli, Maximiliano J. Ramm, Bárbara N. Alarcón-Zapata, José Cordero, Sergio San Martín,
et al.
54857-86-2
Triacsin C
,
Cayman Chemical
,Cat#
10007448
; CAS No.76896-80-5 A922500,
Cayman Chemical
,Cat#
10012708
; CAS No. 959122-11-3
PF-06424439
,
Cayman Chemical
,Cat#
17680
; CAS No. 1469284-79-4
Avasimibe
,
Cayman Chemical
(3)
FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis
bioRxiv
January 6, 2025
Mike Lange, Michele Wölk, Cody E. Doubravsky, Joseph M. Hendricks, Shunji Kato, Yurika Otoki, Benjamin Styler, Kiyotaka Nakagawa, Maria Fedorova, James A. Olzmann
(
Cayman Chemicals
,
36886
), 20 μM
T-863
(
Cayman Chemicals
,
25807
), 15 μM
A-922500
(
Cayman Chemicals
,
10012708
) or 10 μM
PF-06424439
(
Cayman Chemicals
,
17680
).
Lipid droplet
imaging and quantification Cells were
(4)
Inhibitors of VPS34 and fatty-acid metabolism suppress SARS-CoV-2 replication
Cell reports
August 3, 2021
Williams CG, Jureka AS, Silvas JA, Nicolini AM, Chvatal SA, Carlson-Stevermer J, Oki J, Holden K, Basler CF.
(#
10005426
),
TOFA
(#
10005263
),
C75
(#
10005270
),
Etomoxir
(#
11969
), Trimetazidine (#
18165
), and
A-922500
(#
10012708
) were purchased from
Cayman Chemical
(Ann Arbor, Michigan, USA). Remdesivir was purchased from Target
(5)
Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells
Laboratory investigation; a journal of technical methods and pathology
July 1, 2021
Morales A, Greenberg M, Nardi F, Gil V, Hayward SW, Crawford SE, Franco OE.
Oleic Acid
(OA, Cat No.
O3008
,
Sigma Aldrich
, St-Louis, MO) and/or 1 μM DGAT1 inhibitor A-922500 (Cat. No.
10012708
,
Cayman Chemical
, Ann Arbor, MI for at least 48 hours14. RNA silencing Inhibition of EPHB2 expression
(6)
Norepinephrine promotes triglyceride storage in macrophages via beta2-adrenergic receptor activation
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
February 1, 2021
Petkevicius K, Bidault G, Virtue S, Jenkins B, van Dierendonck XAMH, Dugourd A, Saez-Rodriguez J, Stienstra R, Koulman A, Vidal-Puig A.
accumulation in
macrophages
in vivo. 2 MATERIALS AND METHODS 2.1 Reagents All fatty acids and A922500 (
10012708
) were from
Cayman
.
E coli
LPS (
L4391
), (±)‐Norepinephrine (+)‐ bitartrate salt (A0937), fenoterol hydrobromide
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A-922500 from Cayman Chemical
Supplier Page
View Company Product Page
$42.00
Product Specs
Company Info
Citations
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