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Protein Biochemistry
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Doramapimod
Doramapimod from Cayman Chemical
Be the first to write a review!
Citations:
(8)
Supplier Page
Supplier Page from
Cayman Chemical for
Doramapimod
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Description
A highly potent inhibitor of p38 MAPK (Kd = 0.1 nM) that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM; At 10 µM, inhibits JNK2α2 in vitro
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
Doramapimod
Company
Cayman Chemical
Price
$169.00
Supplier Page
View Company Product Page
Catalog Number
10460
Quantity
25 mg
Research Area
Cell Biology, Cell Signaling, Immunology & Inflammation, Innate Immunity, p38 MAPK Signaling
Format
A crystalline solid
Molecular Weight
527.7
Purity
≥98%
Storage
-20
Formula
C31H37N5O3
Origin
USA
Type
Inhibitors
Add to Compare List
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (8)
(1)
Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization
iScience
April 17, 2026
Sophie E. Edelstein, Satoshi Mizoguchi, Maria Tomàs Gracia, Nuoya Wang, Vi Lee, Tomohiro Obata, Hahram Kim, Connor Haynes, Colten Danelski, Tomoshi Tsuchiya,
et al.
BIRB796 (1 μM;
p38-MAPK inhibitor
;
Cayman Chemical
), Y27632 (10 μM; ROCK inhibitor;
Cayman Chemical
,
10460
), and A8301 (1 μM; Activin/NODAL/TGFβ pathway
inhibitor
;
Cayman Chemical
,
9001799
). Further supplements
(2)
Epithelial Reprogramming and Transition during Pulmonary Bioengineering
bioRxiv
January 30, 2026
Satoshi Mizoguchi, Vi Lee, Hahram Kim, Sophie E. Edelstein, Nuoya Wang, Maria Tomas Gracia, Colten Danelski, Connor Haynes, Rachel Rivero, David Stitelman,
et al.
(Peprotech, 400–42), 3 μM
CHIR99021
(
Cayman Chemicals
,
13122
–10 mg), 1 μM BIRB796 (
Cayman Chemicals
,
10460
–10 mg), 10 μM Y27632 (
Cayman Chemicals
,
10005583
–50 mg), and 1 μM A8301 (
Cayman Chemicals
,
9001799
–10
(3)
TGFβ1–TNFα-regulated secretion of neutrophil chemokines is independent of epithelial–mesenchymal transition in breast tumor cells
Molecular Biology of the Cell
October 1, 2025
Shuvasree SenGupta, Erez Cohen, Joseph Serrenho, Kaleb Ott, Pierre A. Coulombe, Carole A. Parent
Formyl-methionyl-leucyl-phenylalanine (fMLF) from
Sigma-Aldrich
(
F3506
); DMSO from Sigma-Aldrich; DMPM from
Cayman Chemicals
(
10460
),
human
CXCL-8 antibody from
R&D systems
(
MAB208-100
), and isotype antibody from
Invitrogen
(
02-6100
(4)
Signaling dynamics distinguish high- and low-priority neutrophil chemoattractant receptors
Science Signaling
October 3, 2023
Stefan M. Lundgren, Briana L. Rocha-Gregg, Emel Akdoğan, Maya N. Mysore, Samantha Hayes, Sean R. Collins
concentrations, including MK-866 (
Cayman Chemicals
catalog #
21753
), BIRB-796 (
Cayman Chemicals
catalog #
10460
),
NVP-BKM120
(
Cayman Chemicals
catalog #
11587
), and SB203580 (
Cayman Chemicals
catalog #
13067
).
Human
(5)
Microcystin-LR (MC-LR) Triggers Inflammatory Responses in Macrophages
International Journal of Molecular Sciences
September 14, 2021
Robin C. Su et al.
San Diego, CA, USA), used at a dose of 2.5 μg/mL, with pretreatments for 1 h.
Doramapimod
(Item No.
10460
;
Cayman Chemical
, Ann Arbor, MI, USA), used at a dose of 10 μM, with pretreatments for 30 min. All treatments
(6)
Combined Inhibition of p38MAPK and PIKfyve Synergistically Disrupts Autophagy to Selectively Target Cancer Cells
Cancer research
June 1, 2021
O''Connell CE, Vassilev A.
Inhibitors
Vacuolin-1
(#
20425
), YM201636 (#
13576
),
Apilimod
(#
19094
), SB202190 (#
10010399
), BIRB-796 (#
10460
),
Skepinone-L
(#
16974
), LY2228820 (#
23259
),
Tak-715
(#
26170
) from
Cayman Chemical
, and WX8 and NDF from
(7)
Tumor Evolution and Drug Response in Patient-Derived Organoid Models of Bladder Cancer
Cell
April 5, 2018
Lee SH, Hu W, Matulay JT, Silva MV, Owczarek TB, Kim K, Chua CW, Barlow LJ, Kandoth C, Williams AB,
et al
.
,
Selleck Chemicals
,Cat#
S7048
Alisertib (MLN8237
),
Selleck Chemicals
,Cat#
S1133
Doramapimod
(BIRB 0796),
Cayman Chemical
,Cat#
10460
Enzastaurin (LY317615),
Cayman Chemical
,Cat#
11601
BI-2536
,
Cayman Chemical
,Cat#
17385
Palbociclib (PD-0332991),
Cayman Chemical
(8)
Pathways for abiotic organic synthesis at submarine hydrothermal fields
Proceedings of the National Academy of Sciences
June 23, 2015
Jill M. McDermott, Jeffrey S. Seewald, Christopher R. German, Sean P. Sylva
deep-seated mid-ocean ridge environments: Insights from stable isotope analyses. J Geophys Res 104(B5):
10439
–
10460
. 13. German CR, et al. (2010) Diverse styles of submarine venting on the ultraslow spreading Mid-
Cayman
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Doramapimod from Cayman Chemical
Supplier Page
View Company Product Page
$169.00
Product Specs
Company Info
Citations
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