CHIR99021 from Cayman Chemical

Product Specs
ItemCHIR99021
CompanyCayman Chemical
Price $39.00Supplier Page View Company Product Page
Catalog Number13122
Quantity1 mg
Research AreaCarbohydrate Metabolism, Cell Biology, Diabetes, Endocrinology & Metabolism, Metabolic Diseases, Reprogramming, Stem Cell Research
FormatA crystalline solid
Molecular Weight465.3
Purity≥95%
Storage-20
FormulaC22H18Cl2N8
OriginCHN
TypeInhibitors

Add to Compare List

Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarizationiScienceApril 17, 2026Sophie E. Edelstein, Satoshi Mizoguchi, Maria Tomàs Gracia, Nuoya Wang, Vi Lee, Tomohiro Obata, Hahram Kim, Connor Haynes, Colten Danelski, Tomoshi Tsuchiya, et al.small molecule inhibitors, including CHIR99021 (3 μM; GSK-3 inhibitor/Wnt activator; Cayman Chemical, 13122), BIRB796 (1 μM; p38-MAPK inhibitor; Cayman Chemical), Y27632 (10 μM; ROCK inhibitor; Cayman Chemical,

(2) Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signalingbioRxivApril 2, 2026Louis S. Prahl, Ronald Canlla, Aria Zheyuan Huang, Daniel S. Alber, Sandra L. Shefter, Sachin N. Davis, Samuel H. Grindel, Zikang Dennis Huang, Thomas R. Mumford, William Benman, et al.Systems), 25 ng ml−1 bone morphogenic protein 4 (BMP4, #120-05ET, PeproTech), 5 μM CHIR99021 (CHIR, #13122, Cayman Chemical), and 25 ng ml−1 FGF2 (#100-18B, PeproTech) over a period of ~25-27 hr 69. Over days

(3) Automated culture and monitoring of a high-throughput human heart-on-a-chipbioRxivMarch 17, 2026Bryan G. Schellberg, Nolan T. Burson, Joshua Gomes, Guohao Dai, Abigail N. Koppes, Ryan A. Koppes(A1895601, Gibco) with 12 μM CHIR99021 for 24 hours. Exactly 24 hours after the addition of CHIR99021 (13122, Cayman Chemical, a complete media change was performed and replaced with differentiation media. On

(4) DCPS modulates TDP-43-linked neurodegeneration through P-body-mediated RNA decayNeuronMarch 9, 2026Yingzhi Ye, Zhe Zhang, Yu Xiao, Chengzhang Zhu, Noelle Wright, Julie Asbury, Yongxin Huang, Weiren Wang, Laura Gomez-Isaza, Juan C. Troncoso, et al.#A4544 LDN193189,Sigma-Aldrich,Cat #SML0559 SB431542,StemCell Technologies,Cat #72234 CHIR99021,Cayman Chemical,Cat #13122 Retina acid,Sigma-Aldrich,Cat #R2625 SAG,Cayman Chemical,Cat #11914 DAPT,Sigma-Aldrich,Cat #D5942 db-cAMP,EMD-Millipore,Cat

(5) SNCA triplication disrupts proteostasis and extracellular architecture prior to neurodegeneration in human midbrain organoidsnpj Parkinson's DiseaseFebruary 16, 2026Elpida Statoulla, Maria Zafeiri, Kleanthi Chalkiadaki, Georgia Voudouri, Karmel S. Gkika, Christos Papazoglou, Thomas M. Durcan, Arkady Khoutorsky, Seyed Mehdi Jafarnejad, Sarah Maguire, et al.(Selleck Chemicals, #S1067), 200 ng/mL Noggin (ImmunoTools, #11344834-rh), 0.8 μM CHIR99021 (Cayman, #13122), and 10 μM ROCK inhibitor Y27632 (Cayman, #129830-38-2)]. Plates were centrifuged for 3 min at 1200

(6) Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identityBiophysical JournalFebruary 13, 2026Abigail Nagle, Cherry Leung, Elaheh Karbassi, Jessica Young, Michael Regnier, Jennifer Daviscells/cm^2. The second day, the media was changed to mTeSR-1 media containing and 1μM Chiron 99021 (Cayman 13122). The following day, Day 0 of differentiation, the media was changed to RBA Media (RPMI media (Gibco)

(7) Epithelial Reprogramming and Transition during Pulmonary BioengineeringbioRxivJanuary 30, 2026Satoshi Mizoguchi, Vi Lee, Hahram Kim, Sophie E. Edelstein, Nuoya Wang, Maria Tomas Gracia, Colten Danelski, Connor Haynes, Rachel Rivero, David Stitelman, et al.(Novus, NBP2–35196-5ug), 50 ng/mL Rat Fgf10 (Peprotech, 400–42), 3 μM CHIR99021 (Cayman Chemicals, 13122–10 mg), 1 μM BIRB796 (Cayman Chemicals, 10460–10 mg), 10 μM Y27632 (Cayman Chemicals, 10005583–50 mg),

(8) Label-free mid-infrared dichroism-sensitive photoacoustic microscopy for histostructural analysis of engineered heart tissuesLight Sci ApplJanuary 4, 2026Eunwoo Park, Dong Gyu Hwang, Hwanyong Choi, Donggyu Kim, Joongho Ahn, Yong-Jae Lee, Tae Joong Eom, Jinah Jang, Chulhong KimTocris Bioscience). On day 1, the medium was replaced with mTeSR1 supplemented with 1 μM CHIR99021 (13122, Cayman Chemical), and cells were cultured for 18 h. Cardiac differentiation medium was prepared using

(9) The Zinc-Finger Protein POGZ Associates with Polycomb Repressive Complex 1 to Regulate Bone Morphogenetic Protein Signaling During Neuronal DifferentiationStem Cell Reviews and ReportsJanuary 2, 2026Jessenia Chavez, Trevor Wolf, Cynthia Lascarez Espana, Zhuangzhuang Geng, Yen Teng Tai, John Flanagan, George-Lucian Moldovan, James Stafford, Zhonghua GaoGSK3) inhibitors (PD0325901, Cayman Chemical, cat. no. 13034, and CHIR99021, Cayman Chemical, cat. no. 13122). When revived from liquid nitrogen, ESCs are initially plated on mitotically arrested mouse embryonic

(10) Synchronization of the segmentation clock using synthetic cell–cell signalingGenes & DevelopmentJanuary 1, 2026Akihiro Isomura, Daisuke Asanuma, Ryoichiro KageyamamESCs were maintained in NDiff227 medium (Takara Bio Y40002) supplemented with 3 µM CHIR99021 (Cayman 13122), 1.5 µM CGP77675 (Cayman 21089), 1000 U/mL leukemia inhibitory factor (StemSure LIF, FujiFilm Wako

(11) Single cell transcriptional perturbome in pluripotent stem cell modelsMolecular Systems BiologyDecember 10, 2025Elisa Balmas, Maria L Ratto, Kirsten E Snijders, Silvia Becca, Carla Liaci, Irene Ricca, Giorgio R Merlo, Raffaele A Calogero, Luca Alessandrì, Sasha Mendjan, et al.differentiations),STEMCELL Technologies,#100-0177 Ascorbic acid,Waco-chemicals,#321-44823 CHIR99021,Cayman chemicals,#13122 Wnt-C59,Cayman chemicals,#16644 B27 supplement,Gibco,#17504044 Trypsin,Gibco,#25200056 Fetal bovine

(12) Generation and transcriptome profiling of bonobo induced pluripotent stem cells using stealth RNA vectors: a tripartite comparative study with humans and chimpanzeesBMC GenomicsDecember 5, 2025Yusuke Hamazaki, Hiroto Akuta, Hikaru Suzuki, Hideyuki Tanabe, Tsubasa Suzuki, Kouki Inoue, Kenji Ichiyanagi, Takuya Imamura, Masanori Imamuraand 100 µg/ml streptomycin) supplemented with 30 ng/ml activin A (014–27621; Wako), 6 μM CHIR99021 (13122; Cayman Chemical Company), 40 ng/ml human BMP4 (120-05ET; Peprotech, Cranbury, NJ, USA), 20 ng/ml human

(13) Loss of lung mesenchymal identities in culture and a screening approach to identify restorative cuesAmerican Journal of Physiology-Lung Cellular and Molecular PhysiologyDecember 1, 2025Ana M. Diaz Diaz Espinosa, Jack H. Wellmerling, Natalia Del Pilar Del Pilar Vanegas, Jhonny Rodriguez-Lopez, Kyoung M. Choi, Nichole A. Schussler, Patrick A. Link, Luis R. Rodriguez, Grant Barringer, Mauricio Rojas, et al.49]" PGE2,MedChem Express,HY-101952(363-24-6),322869,DMSO,10mM,100nM,"[50, 51]" CHIR99021,Cayman Chemical,13122(252917-06-9),0604063-173,DMSO,15mM,3uM,[44] Rosiglitazone,Cayman Chemical,71740(122320-73-4),0487968-262,DMSO,60mM,30uM,[52] Y-27632 Hydrochloride

(14) Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoidsCell Reports MedicineNovember 6, 2025Shuntaro Kawamura, Yosuke Yoneyama, Norikazu Saiki, Yunheng Wu, Chiharu Moriya, Rio Ohmura, Mari Maezawa, Yoshihiro Shimada, Yicheng Wang, Kensaku Mori, et al.containing 80 ng/mL BMP4 (R&D, 314-BP), 80 ng/mL VEGF-A (Invitrogen, PHC9393), and 2–4 μM CHIR99021 (Cayman, 13122) for 2 days. On day 2, a micropatterned colony including the Primitive Streak and Yolk Sac Mesoderm

(15) Generation of exogenous kidneys via CRISPR/Cas9 mediated blastocyst complementation targeting Osr1 gene in miceScientific ReportsNovember 4, 2025Ting-Yu Yeh, Ing-Ming Chiu, Yu-Jia Huang, Shinn-Chih Wu, Chia-Chun Hsieh, Hsiang-Hsuan Sung, Wuh-Liang Hwu, Gou-Jen Wang, Jyh-Cherng Juβ-mercaptoethanol, 103 IU/ml mLIF (Millipore, ESG1107), 1 µM PD0325901 (Tocris, 4192) and 3 µM CHIR99021 (Cayman, 13122). With TrypLE, ES cells are passaged every 2 to 4 days before the growing colonies contact neighboring

(16) The G256E HCM mutation prolongs cardiac muscle relaxation via altered nucleotide handlingResearch SquareOctober 16, 2025Michael Regnier, Kerry Kao, Matthew Childers, Divya Pathak, Rama Reddy Goluguri, Timothy McMillen, Kathleen Ruppel, James SpudichStemcell Technologies). On day −1, the day prior to differentiation, mTeSR1 media was supplemented with 1 μM CHIR99021 (13122, Cayman Chemical). On day 0, hiPSCs were induced with 5 μM CHIR99021 in a chemically defined media composed

(17) Protocol for generating liver organoids containing Kupffer cells using human iPSCsSTAR ProtocOctober 10, 2025Yang Li, Yunzhong Nie, Hideki Taniguchisolution, human, recombinant",Nacalai Tesque,Cat# 18585-81 CHIR99021,Cayman Chemical Company,Cat# 13122 Sodium butyrate (NaB),Sigma,Cat# B5887 Dimethyl sulfoxide (DMSO),Nacalai,Cat# 13408-64 2-Mercaptoethanol,Gibco,Cat#

(18) Munc13-1 restoration mitigates presynaptic pathology in spinal muscular atrophyNature communicationsSeptember 30, 2025Moradi M, Weingart J, Deng C, Nasouti M, Briese M, Jablonka S, Sauer M, Sendtner M.10 µM), dorsomorphin homolog 1 (DMH1) (R&D Systems, 4126, 1 µM), CHIR99021 (Cayman Chemical Company, 13122, 3 µM), and Purmorphamine (PMA) (Cayman Chemical Company, 10009634, 0.5 µM). On day 2, mTeSR Plus medium

(19) Functional variants of CFAP410 affect the DNA damage response leading to motor neuron degeneration – Implications for ALSiScienceSeptember 19, 2025Ross Ferguson, Vasanta Subramanianproteins","Chemicals, peptides, and recombinant proteins" ,, SB431542,Cayman,Cat# 04-0010-05 CHIR99021,Cayman,Cat#13122 DMH1,Tocris,Cat# 4126 growth factor-reduced Matrigel,Corning,Cat# 354230 FGF2,Peprotech,Cat# 100-18B EGF,Peprotech,Cat#

(20) Temporal transcriptomic profiling of human three-dimensional neuromuscular co-culturesBiology OpenSeptember 15, 2025Neha Jadhav Giridhar, Bita Hambrecht, Maren Schenke, Bettina Seeger, Thorsten Bischler, Michael Briese, Patrick LüningschrörA10826-50), 1 µM dorsomorphin homolog 1 (DMH1) (R&D Systems, 4126), 3 µM CHIR99021 (Cayman Chemical Company, 13122), and 0.5 µM Purmorphamine (PMA) (Cayman Chemical Company, 10009634). On day 2, the medium was switched

Be the First to Write a Review!

CHIR99021 from Cayman Chemical

Description

Cayman Chemical

Citations (138)

Reviews

CHIR99021 from Cayman Chemical

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map