Description
An antagonist of EP1 (Ki = 1.332 µM); selective for EP1 over EP2, EP3, and EP4 (Kis = >100, 17.5, and >100 µM, respectively), as well as DP, FP, IP, and TP (Kis = >100, 61.13, >100, and 11.18 µM, respectively); decreases Aβ42-induced cell death in MC65 cells from 10-50 µM; inhibits the growth of KMG-4 glioma cells in vitro (IC50 = ~1 µM); reduces tumor growth in a KMG-4 mouse xenograft model at 25 mg/kg; reduces phenylbenzoquinone-induced writhing in mice (ED50 = 6.8 mg/kg)