Description
Δ8-THC analog with 13-fold selectivity for the CB2 receptor (Kis = 12.3 and 0.91 nM, for CB1 and CB2 respectively); its CB agonist activity inhibits human U87 glioma cell proliferation in vitro ( IC50 = 1.4 µM) and in vivo (2 mg/kg in a SCID mouse xenograft side-pocket model)