Welcome Guest
Sign In
Register
Products
Popular Categories
Antibody Search
ELISA Kit Search
Biomolecules
Flow Cytometers
Thermal Cyclers
Microscopes
Transfection Reagents
Featured Products
New Products
Research Areas
ELISA
Western Blot
3D Cell Culture
Digital PCR
Quantitative PCR
Cell and Gene Therapy
In Vivo Models
Resources
eBooks
Bench Tips
Tech Insights
Editorial Articles
News
Product Reviews
Future Lab
White Papers
Infographics
Events
Promotions
Multimedia
Biocompare Webinars
Technologies Transforming Precision Medicine
Immunotherapy
Reproducibility
Transformative Technologies
Podcasts
Bench Tip Videos
All Videos and Webinars
Life Science Webinars
Write a Review
Antibodies
Kits/Reagents
Equipment
Services
Register
Sign In
Biocompare
Products
Protein Biochemistry
Chemicals and Reagents
PD 98059
PD 98059 from Cayman Chemical
Be the first to write a review!
Citations:
(10)
Supplier Page
Supplier Page from
Cayman Chemical for
PD 98059
Request Info
Description
A MAPK pathway inhibitor and AMPK activator; prevents the activation of MAP2K1 by Raf or MEK kinase (IC50 = 2-7 µM); activator of AMPK (EC50 = 35 µM); increases the ratios of ADP:ATP and AMP:ATP
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
PD 98059
Company
Cayman Chemical
Price
$97.00
Supplier Page
View Company Product Page
Catalog Number
10006726
Quantity
10 mg
Research Area
Cancer, Cell Biology, Cell Signaling, Endocrinology & Metabolism, ERK/MAPK Signaling, Nutrient Sensing
Format
A crystalline solid
Molecular Weight
267.3
Purity
≥98%
Storage
-20
Formula
C16H13NO3
Origin
CHN
Type
Inhibitors
Add to Compare List
Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (10)
(1)
Selective tubulin-binding drugs induce pericyte phenotype switching and anti-cancer immunity
EMBO Molecular Medicine
March 26, 2025
Bo He, Kira H Wood, Zhi-jie Li, Judith A Ermer, Ji Li, Edward R Bastow, Suraj Sakaram, Phillip K Darcy, Lisa J Spalding, Cameron T Redfern,
et al.
Bioscience,A10976 Eribulin,Eisai Inc.,n/a Fasudil,LKT Laboratories,F0275 PD98059,
Cayman Chemical
,
10006726
Wortmannin,
Selleck Chemical
,
S2758
Lectin-FITC (
Lycopersicon esculentum
),Vector,FL-1171 Hypoxyprobe
(2)
Non-Psychoactive Phytocannabinoids Inhibit Inflammation-Related Changes of Human Coronary Artery Smooth Muscle and Endothelial Cells
Cells
September 30, 2023
Teichmann E, Blessing E, Hinz B.
(Schwerte, Germany).
AM251
(#
71670
),
AM630
(#
10006974
),
SB203580
(#
13067
),
SP600125
(#
10010466
),
PD98059
(#
10006726
),
BAY 11-7082
(#
10010266
), trichostatin A (TSA, #
89730
), and sirolimus (#
13346
) were obtained from
Cayman Chemical
(3)
ZNF768 links oncogenic RAS to cellular senescence
Nature communications
August 17, 2021
Villot R, Poirier A, Bakan I, Boulay K, Fernández E, Devillers R, Gama-Braga L, Tribouillard L, Gagné A, Duchesne É,
et al
.
reagents were used
in cell culture
experiments:
Tamoxifen
(
Sigma
, #
T5648
), PD098059 (
Cayman Chemical
, #
10006726
), Torin1 (
Cayman Chemical
, #
10997
),
Cycloheximide
(
Sigma
, #
C7698
), Puromycin (
Sigma
, #
P8833
), Blasticidin
(4)
Tofacitinib overcomes an IFNγ-induced decrease in NK cell-mediated cytotoxicity via the regulation of immune-related molecules in LC-2/ad
Thoracic cancer
March 1, 2021
Okita R, Shimizu K, Nojima Y, Saisho S, Nakata M.
cell culture
, tofacitinib (#
S5001
,
Selleck
), gefitinib (#
13166
;
Cayman
),
LY294002
(#
70920
;
Cayman
), PD98059 (#
10006726
;
Cayman
), and PF4708671 (#
4032
;
Tocris
) stock solutions were prepared in DMSO (Sigma‐Aldrich), whereas
(5)
Cadmium exposure activates Akt/ERK Signaling and pro-inflammatory COX-2 expression in human gallbladder epithelial cells via a ROS dependent mechanism
Toxicology in vitro : an international journal published in association with BIBRA
September 1, 2020
Sharma P, Caldwell TS, Rivera MN, Gullapalli RR.
Aldrich (St. Louis, MO, US).
LY294002
(PI3K
Inhibitor
; cat #
70920
), PD98059 (MAPKK
Inhibitor
; cat #
10006726
) and MG-132 (Proteosome
inhibitor
; cat #
13697
) were purchased for
Cayman Chemicals
(Ann Arbor, Michigan,
(6)
Rosmarinic acid suppresses adipogenesis, lipolysis in 3T3-L1 adipocytes, lipopolysaccharide-stimulated tumor necrosis factor-α secretion in macrophages, and inflammatory mediators in 3T3-L1 adipocytes
Food & nutrition research
January 1, 2017
Rui Y, Tong L, Cheng J, Wang G, Qin L, Wan Z.
and trypsin/ethylenediaminetetraacetic acid (EDTA) solution. RA (cat. no. 70900),
PD98059
(cat. no.
10006726
), forskolin (cat. no.
11018
), wortmannin (cat. no.
10010591
), rolipram (cat. no.
10011132
), cilostamide
(7)
Human adipose tissue conditioned media from lean subjects is protective against H2O2 induced neurotoxicity in human SH-SY5Y neuronal cells
International journal of molecular sciences
January 6, 2015
Wan Z, Mah D, Simtchouk S, Kluftinger A, Little JP.
modified Eagle medium nutrient mixture F-12 Ham (DMEM-F12) and Trypsin/EDTA solution.
PD98059
(cat#
10006726
),
SP600125
(cat#
10010466
) and
LY294002
(cat#
70920
) were obtained from
Cayman chemicals
(Burlington,
(8)
Contrasting Effects of the Cytotoxic Anticancer Drug Gemcitabine and the EGFR Tyrosine Kinase Inhibitor Gefitinib on NK Cell-Mediated Cytotoxicity via Regulation of NKG2D Ligand in Non-Small-Cell Lung Cancer Cells
PloS one
January 1, 2015
Okita R, Wolf D, Yasuda K, Maeda A, Yukawa T, Saisho S, Shimizu K, Yamaguchi Y, Oka M, Nakayama E,
et al
.
(
Cayman
, #
13166
),
Docetaxel
(
Enzo Life Sciences
,
BML-T129
),
LY294002
(
Cayman
, #
70920
), PD98059 (
Cayman
, #
10006726
) and KU55933 (
Tocris Bioscience
, #
3544
) were dissolved in DMSO (Sigma-Aldrich). Gemcitabine (
Tocris Bioscience
(9)
Nesfatin-1 Induces the Phosphorylation Levels of cAMP Response Element-Binding Protein for Intracellular Signaling in a Neural Cell Line
PLoS ONE
December 6, 2012
Emi Ishida, Koshi Hashimoto, Hiroyuki Shimizu, Shuichi Okada, Tetsurou Satoh, Ikuo Kato, Masanobu Yamada, Masatomo Mori
Merck KGaA
, Darmstadt, Germany);
KT5720
(#K3761,
Sigma
); Wortmannin (#
W1628
,
Sigma
); and PD98059 (#
10006726
,
Cayman
) were employed as chemical
inhibitors
of cell signaling pathway in the study. Nesfatin-1, M30,
(10)
Mechanical Strain Regulates Osteoblast Proliferation through Integrin-Mediated ERK Activation
PLoS ONE
April 23, 2012
Yu-xian Yan, Yuan-wei Gong, Yong Guo, Qi Lv, Chun Guo, Yan Zhuang, Yuan Zhang, Ruixin Li, Xi-zheng Zhang
Lipofectamine 2000 and fluorescent oligomers were purchased from Invitrogen (Carlsbad, CA, USA). PD98095 (sc-
10006726
) was purchased from
Cayman
(Cayman Chemical, USA). All other chemicals of reagent grade were obtained
<<
<
>
>>
Reviews
Be the First to Write a Review!
PD 98059 from Cayman Chemical
Supplier Page
View Company Product Page
$97.00
Product Specs
Company Info
Citations
Reviews
Back To Top