Lactacystin from Cayman Chemical

Product Specs
ItemLactacystin
CompanyCayman Chemical
Price $387.00Supplier Page View Company Product Page
Catalog Number70980
Quantity1 mg
Research AreaCell Biology, Proteolysis, Ubiquitin/Proteasome System
FormatA clear film
Molecular Weight376.4
Purity≥98%
Storage-20
FormulaC15H24N2O7S
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) The deubiquitinase OTULIN regulates tau expression and RNA metabolism in neuronsGenomic PsychiatryNovember 29, 2025Karthikeyan Tangavelou, Virginie Bondu, Mingqi Li, Wei Li, Francesca-Fang Liao, Kiran Bhaskarinhibitors were procured from Cayman Chemical. Cycloheximide (Cayman # 26924), Lactacystin (Cayman # 70980), MG132 (Cayman # 13697), Baf A1 (Cayman # 11038), and PD 150606 (Cayman # 13859). The following antibodies

(2) Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYCCancers (Basel)February 4, 2022Shannon E. Moree, Laure Maneix, Polina Iakova, Fabio Stossi, Ergun Sahin, Andre Catic[36]. 2.5. Proteasome Inhibitions Cells were treated with 12.5 μM Lactacystin (Cayman Chemical, Cat. 70980) for 6 h to inhibit protein degradation by the proteasome prior to FACS analysis. The fast-acting drug

(3) Lack of Parkinsonian Pathology and Neurodegeneration in Mice After Long-Term Injections of a Proteasome Inhibitor in Olfactory Bulb and AmygdalaFrontiers in Aging NeuroscienceOctober 21, 2021Natalia Lopez-Gonzalez del Rey, Tiziano Balzano, Lucia Martin-Rodriguez, Constanza Salinas-Rebolledo, Ines Trigo-Damas, Alejandro Rojas-Fernandez, Lydia Alvarez-Erviti, Javier Blesasecured in a stereotaxic frame and injected with lactacystin in the left hemisphere (Cayman, reference 70980) at a final concentration of 2 μg/μl (in 0.9% NaCl). The lactacystin solution was always prepared fresh

(4) Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's diseaseNature communicationsSeptember 6, 2021Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, Lundberg K, Adams DJ, Qi X.(Burlington, MA, USA). CHIR99021 (S2924) was from Selleckchem (Houston, TX, USA). MG132 (13697), lactacystin (70980), epoxomicin (10007806), BFA (11038), tunicamycin (11445), and thapsigargin (10522) were purchased from

(5) The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genesScientific ReportsDecember 1, 2020Melanie A. Sweeney, Polina Iakova, Laure Maneix, Fu-Yuan Shih, Hannah E. Cho, Ergun Sahin, Andre Caticperformed for 3 h prior to ChIP with 25 µM lactacystin or 0.1% v/v DMSO control (Cayman Chemical, #70980). Cells were washed and fixed in 1% para-formaldehyde in PBS (Thermo Scientific, #28906) at room temperature

(6) Fbxl18 targets LRRK2 for proteasomal degradation and attenuates cell toxicityNeurobiology of diseaseFebruary 1, 2017Ding X, Barodia SK, Ma L, Goldberg MS.cocktail (11873580001) was purchased from Roche Molecular Biochemicals (Indianapolis, IN). Lactacystin (70980) was purchased from Cayman Chemical (Ann Arbor, MI). ImmunoPure Immobilized Protein A/G beads (20421)

(7) Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ lineDevelopmentJanuary 15, 2015Pratyush Gupta, Lindsay Leahul, Xin Wang, Chris Wang, Brendan Bakos, Katie Jasper, Dave Hansentreatment was performed as previously described (Ding et al., 2007). Lactacystin (Cayman Chemicals, #70980) in DMSO, or DMSO alone, was added to synchronized wild-type L1 animals in M9 minimal medium containing

(8) Recycling of Kinesin-1 Motors by Diffusion after TransportPLoS ONESeptember 30, 2013T. Lynne Blasius, Nathan Reed, Boris M. Slepchenko, Kristen J. Verheypurchased from Sigma (#H4541, 30 mM final concentration). Lactacystin was purchased from Cayman Chemical (#70980, 5 mM final concentration). All other inhibitors were purchased from Calbiochem: ALLN (N-AcetylLeu-Leu-Nle-CHO,

(9) A Bovine Herpesvirus 1 Protein Expressed in Latently Infected Neurons (ORF2) Promotes Neurite Sprouting in the Presence of Activated Notch1 or Notch3Journal of VirologyJanuary 15, 2013Devis Sinani, Leticia Frizzo da Silva, Clinton Jonesthe indicated time points. To block proteasome activity, cells were treated with 15 ␮M lactacystin (70980; Cayman Chemical) 10 h prior to CHX treatment. Cells were subsequently processed for Western blot analysis. Journal

(10) Development of quantitative and high-throughput assays of polyomavirus and papillomavirus DNA replicationVirologyMarch 30, 2010Fradet-Turcotte A, Morin G, Lehoux M, Bullock PA, Archambault J.geldanamycin, 2 μM for 17-AAG and 10 μM for lactacystin. Lactacystin was purchased from Cayman (Cat: 70980), geldanamycin and 17-AAG from BIOMOL international (Cat: EI-280 and EI-308, respectively) and both

(11) Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIPPloS oneJune 17, 2009Ding X, Goldberg MS.(Indianapolis, IN). Geldanamycin was purchased from Alexis Biochemicals (San Diego, CA). Lactacystin (70980) was purchased from Cayman Chemical (Ann Arbor, MI). ImmunoPure Immobilized Protein A/G beads (20421)

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Lactacystin

Lactacystin

Lactacystin from Cayman Chemical

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Cayman Chemical

Citations (11)

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Lactacystin from Cayman Chemical

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