Description
A potent and noncompetitive inhibitor of MAGL (IC50 = 200 nM for the recombinant rat brain enzyme); inhibits rat brain FAAH (IC50 = 32 µM); binds weakly to the rat CB1 receptor (IC50 = 3.8 µM); does not inhibit COX-1 or COX-2 at concentrations up to 100 µM