Reversine from Cayman Chemical

Product Specs
ItemReversine
CompanyCayman Chemical
Price $302.00Supplier Page View Company Product Page
Catalog Number10004412
Quantity10 mg
Research AreaAutophagy, Cancer, Cell Biology, Cell Cycle, Cell Signaling, Cytoskeleton & Motor Proteins, Differentiation, Endomembrane System & Vesicular Trafficking, PI3K/Akt/mTOR Signaling, Stem Cell Research
FormatA crystalline solid
Molecular Weight393.5
Purity≥95%
Storage-20
FormulaC21H27N7O
OriginCHN

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Cell confinement initiates a delayed but heritable loss of chromosomesCell RepMarch 24, 2026Steven H. Phan, Mai Wang, Kayla R. Snare, Jonah Kandell, Jeneille S. Deans, Panteleimon Rompolas, Guilherme P.F. Nader, Dennis E. Dischertreatments were used: MPS1 inhibitor reversine (A549: 50nM, H23: 50nM, U2OS: 0.5μM) (Cayman Chemical 10004412), Nocodazole (0.1μM or 0.3μM) (MilliporeSigma M1404), CDK4/6 inhibitor Palbociclib (10μM) (Cayman Chemical

(2) ER-tethering directs TREX1 penetration of a BAF-dependent barrier at micronucleiMol CellMarch 19, 2026Yanyang Chen, Roshan Xavier Norman, Eléonore Toufektchan, Xiaohan Luan, Abraham Shim, Hannah Rosenberg, Marton Tibor Kovacs, Ashley Nichols, James Hickling, Paolo Cifani, et al.Express,HY-N0565B ER tracker,Thermo Fisher Scientific,E34250 Nocodazole,Cayman,13857-50 Reversine,Cayman,10004412 ProLong Gold antifade reagent,Invitrogen,P36934 "Protease Inhibitor Tablets, EDTA-free",Thermo Scientific,A32965 Agarose,TransGen,GS201-01 HEPES,Sangon,A600264 Tris,Sangon,A501492 Potassium

(3) Cell confinement initiates a delayed but heritable loss of chromosomesbioRxivFebruary 3, 2026Steven H. Phan, Mai Wang, Kayla R. Snare, Jonah Kandell, Jeneille S. Deans, Panteleimon Rompolas, Guilherme P.F. Nader, Dennis E. Dischertreatments were used: MPS1 inhibitor reversine (A549: 50nM, H23: 50nM, U2OS: 0.5μM) (Cayman Chemical 10004412), Nocodazole (0.1μM or 0.3μM) (MilliporeSigma M1404), CDK4/6 inhibitor Palbociclib (10μM) (Cayman Chemical

(4) Development of large-scale gastruloid array to identify aberrant developmental phenotypesAPL BioengJune 10, 2025Ian Jan, Andrew Cearlock, Min Yang, Nancy L. Allbrittontissue culture-treated plates coated with 1% Matrigel. Reversine-treated cells were incubated in 0.5 µM reversine (#10004412, Cayman Chemicals Co., Ann Arbor, MI) in mTeSR Plus for 48 h with a medium change after 24 h. F. Gastruloid

(5) MPS1 promotes timely spindle bipolarization to prevent kinetochore-microtubule attachment errors in oocytesThe EMBO JournalJune 4, 2025Shuhei Yoshida, Reiko Nakagawa, Kohei Asai, Tomoya S KitajimamMACHINE T7 kit,invitrogen,AM1344 3-isobutyl-1-methyl-xanthine,Sigma-Aldrich,15879 Reversine,Cayman,10004412 AZ3146,Selleck,S2731 proTAME,RD systems,554-17621 Nocodazole,Sigma-Aldrich,M1404 Anti-GFP mAb-Magnetic

(6) The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistanceCellOctober 17, 2024Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, Agata Smogorzewska, Jin Chen, et al.Ant-zn-05 Nocodazole,Millipore-Sigma,Cat# 487928 Colcemid (KaryoMAX),Gibco,Cat# 15212012 Reversine (Mps1 inhibitor),Cayman Chemical,Cat# 10004412 NMS-P715 (Mps1 inhibitor),Cayman Chemical,Cat# 31613 Mitomycin C,Sigma-Aldrich,Cat# M4287 Methotrexate,Calbiochem,Cat#

(7) Haploidy-linked cell proliferation defects limit larval growth in zebrafishOpen biologyOctober 1, 2024Yaguchi K, Saito D, Menon T, Matsura A, Hosono M, Mizutani T, Kotani T, Nair S, Uehara R.min at 66 h post-fertilization (hpf). For SAC inactivation, larvae were treated with 5 μM reversine (10004412, Cayman Chemical) from the time points described elsewhere. Treatment with 0.5% DMSO was used as vehicle

(8) Simple aneuploidy evades p53 surveillance and promotes niche factor-independent growth in human intestinal organoidsMolecular Biology of the CellAugust 1, 2024Blake A. Johnson, Albert Z. Liu, Tianhao Bi, Yi Dong, Taibo Li, Dingjingyu Zhou, Akshay Narkar, Yufei Wu, Sean X. Sun, Tatianna C. Larman, et al.passage. Drug treatments The following drugs were used in this study: reversine [Cayman Chemical, Catalogue# 10004412], doxorubicin [Sigma Aldrich, Catalogue# AMBH324A4B72], nutlin-3a [Sigma Aldrich, Catalogue# N6287],

(9) Cell Competition Eliminates Aneuploid Human Pluripotent Stem CellsbioRxiv : the preprint server for biologyMay 10, 2024Ya A, Deng C, Godek KM.129830-38-2 Versene Solution,Thermo Fisher Scientific,Cat# Catalog No.15-040-066 Reversine,Cayman Chemical,Cat# 10004412; CAS: 656820-32-5 mTeSR1,StemCell Technologies,Cat# 85850 mTeSR Plus,StemCell Technologies,Cat# 100-0276 mTeSR1

(10) Micronucleus is not a potent inducer of the cGAS/STING pathwayLife Science AllianceApril 1, 2024Yuki Sato, Makoto T HayashiHesperadin (24199; Cayman Chemical) for 2 d. For MPS1 inhibition, cells were exposed to 0.5 μM reversine (10004412; Cayman Chemical) for 24 h from 2 d after shTREX1-A transduction. For VDAC1 inhibition, cells were exposed

(11) Age-dependent loss of cohesion protection in human oocytesCurrent biology : CBJanuary 8, 2024Mihalas BP, Pieper GH, Aboelenain M, Munro L, Srsen V, Currie CE, Kelly DA, Hartshorne GM, Telfer EE, McAinsh AD, et al.BUB1 inhibition at metaphase II, oocytes were treated with 500nM reversine (Cayman Chemical Research, 10004412)28 or 10μM BAY-320 (MedChemExpress, HY-104000),47,56 respectively for 16 hrs prior to fixation, or with

(12) Genetic heterogeneity in p53-null leukemia increases transiently with spindle assembly checkpoint inhibition and is not rescued by p53ChromosomaJanuary 1, 2024Mai Wang, Steven Phan, Brandon H. Hayes, Dennis E. DischerThe following chemical treatments were used: MPS1 inhibitor reversine (Cayman Chemical, Catalog no. 10004412), H2O2 (Fisher Chemical, Catalog no. H323), Pifithrin-μ (PFT-μ, AmBeed, Catalog no. A370437), and dimethyl sulfoxide (DMSO

(13) Genuine selective caspase-2 inhibition with new irreversible small peptidomimeticsCell death & diseaseNovember 15, 2022Bosc E, Anastasie J, Soualmia F, Coric P, Kim JY, Wang LQ, Lacin G, Zhao K, Patel R, Duplus E, et al.progenitor cells H9-hNPCs were pretreated (or not) for 1 h with LJ3a and treated with 1 µM reversine (#10004412, Cayman Chemicals, Ann Arbor, MI) for 24 h. Each condition was done in triplicate. Media was then removed,

(14) Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse OocytesJournal of Visualized ExperimentsOctober 3, 2022Mansour Aboelenain, Karen Schindler, Cecilia S. Blenginianti- MAD2,Biolegend,924601,Dilution 1/1000; previously Covance #PRB-452C Reversine,Cayman Chemical,10004412, Triton-X,Sigma,274348, Tween-20,Sigma,X100, Table of Materials

(15) Pathogenic mutations in the chromokinesin KIF22 disrupt anaphase chromosome segregationeLifeJune 22, 2022Thompson AF, Blackburn PR, Arons NS, Stevens SN, Babovic-Vuksanovic D, Lian JB, Klee EW, Stumpff J.hr before imaging, and 500 nM nocodazole (Selleckchem #S2775) and 900 nM reversine (Cayman Chemical #10004412) approximately 0.5–1 hr before imaging. Cells were imaged at 5-min intervals. Nuclear solidity was measured

(16) Aurora kinase A is essential for meiosis in mouse oocytesPLoS geneticsApril 1, 2021Blengini CS, Ibrahimian P, Vaskovicova M, Drutovic D, Solc P, Schindler K.culture media at a final concentration of 1 μM. To inhibit the SAC, reversine (Cayman Chemical Research #10004412) was added to CZB culture media at a final concentration of 1 μM. Dimethyl sulfoxide (Sigma Aldrich

(17) Kinetochore individualization in meiosis I is required for centromeric cohesin removal in meiosis IIThe EMBO JournalApril 1, 2021Yulia Gryaznova, Leonor Keating, Sandra A Touati, Damien Cladière, Warif El Yakoubi, Eulalie Buffin, Katja Wassmann1.5 and 5 µM for meiosis I and meiosis II experiments, respectively, and Reversine (Cayman Chemical, 10004412) was used at 0.5 µM and additionally added to the oil used to cover the culture droplets. In vitro transcription

(18) Purification of micronuclei from cultured cells by flow cytometrySTAR protocolsMarch 19, 2021Toufektchan E, Maciejowski J.ProLong Gold antifade reagent,Invitrogen,Cat#P36934 "Protease inhibitor tablets, EDTA-free",Thermo Scientific,Cat#A32965 Reversine,Cayman Chemical Company,Cat#10004412 Spermidine,Thermo Fisher Scientific,Cat#AC132740010 Spermine,Thermo Fisher Scientific,Cat#AC132750010 Trypsin

(19) ER-directed TREX1 limits cGAS activation at micronucleiMolecular cellFebruary 18, 2021Mohr L, Toufektchan E, von Morgen P, Chu K, Kapoor A, Maciejowski J.,Thermo Scientific,Cat#A32965 Quick-RNA Miniprep Kit,Zymo,Cat#R1054 Reversine,Cayman Chemical Company,Cat#10004412 SYBR Green Master Mix,Applied Biosystems,Cat#A25742 Spermidine,Thermo Fisher Scientific,Cat#AC132740010 Spermine,Thermo

(20) BUB1 and CENP-U, Primed by CDK1, Are the Main PLK1 Kinetochore Receptors in MitosisMolecular cellJanuary 7, 2021Singh P, Pesenti ME, Maffini S, Carmignani S, Hedtfeld M, Petrovic A, Srinivasamani A, Bange T, Musacchio A.Acid,Merck,Cat#04906845001 RO-3306,Millipore,Cat#217699 MG-132,Calbiochem,CAS 133407-82-6 Reversine,Cayman Chemical,Cat#10004412 Hesperadin,Merck,Cat#375680-5MG Fetal bovine serum (FBS),Clonetech,Cat#631107 Zeocin,Invitrogen,Cat#R25001 L-glutamine,PAN

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Reversine

Reversine

Reversine from Cayman Chemical

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Cayman Chemical

Citations (30)

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Reversine from Cayman Chemical

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