Description
A CysLT2 receptor antagonist (IC50 = 53 nM); selectively inhibits LTD4-induced calcium mobilization in HEK293 cells expressing human CysLT2 receptors over HEK293 cells expressing CysLT1 receptors at 100 nM; reverses LTC4-induced increases in coronary artery perfusion pressure and decreases in contractility in isolated perfused guinea pig hearts; reduces infarct volume in a human CysLT2 receptor transgenic mouse model of LAD ligation-induced myocardial ischemia and reperfusion injury at 3 mg/kg