DAPT from Cayman Chemical

Product Specs
ItemDAPT
CompanyCayman Chemical
Price $117.00Supplier Page View Company Product Page
Catalog Number13197
Quantity10 mg
Research AreaAlzheimer’s Disease, Cell Biology, Lysosomal Proteases, Neurodegenerative Disorders, Neuroscience, Proteolysis
FormatA crystalline solid
Molecular Weight432.5
Purity≥95%
Storage-20
FormulaC23H26F2N2O4
OriginCHN
TypeInhibitors

Add to Compare List

Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) ATP13A2 Loss of Function-Driven Polyamine Dysregulation Induces SAM Depletion and Epigenetic Astrocyte ToxicitybioRxivApril 6, 2026Elena Coccia, Gustavo Morrone Parfitt, Sundas Ijaz, Aisha Sati, Julia Gesner, Andrea Perez Arevalo, Jennifer Strong, Anna Bright, Soha Sohail, Thea Meimoun, et al.secondary antibodies for 1 hour at RT. Nuclei were counterstained with Hoechst 33342 (Cayman Chemical, #13197) for 5 minutes. Organoids were harvested, washed with PBS without calcium or magnesium (PBS−/−), and

(2) PTEN-AKT2 Regulates Mixed Lineage Liver Cancer Development and Sensitizes Cancer Cells to TGFβ TreatmentResearch SquareJanuary 31, 2026Bangyan Stiles, Ielyzaveta Slarve, Ielyzaveta Slarve, Jingyu Chen, Yiwei Zeng, Yiwei Gu, Shunan He, Shunan Alhousari, Diala Alhousari, Brittney Hua, et al.with DAPT (N-[N-(3,5-difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester) (Cayman Chemical, #13197) or recombinant human TGFβ1 protein (Abcam, #ab50036) as indicated. SOX9 knockdown and NICD1 overexpression

(3) Development of a split-toxin CRISPR screening platform to systematically identify regulators of human myoblast fusionNature CommunicationsJanuary 15, 2026Haifeng Zhang, Renjie Shang, Zheng Zhang, Min Zhou, Anne Bigot, Yanqing Cai, Yanran Zhao, Yushu Wang, Aaryahi Deshmukh, Elena Kudryashova, et al.cultured in differentiation medium comprising DMEM supplemented with 2% horse serum, 10 μM DAPT (Cayman, 13197), and 1% penicillin/streptomycin. Karyotype analysis was performed by KaryoStat™ Assay using Genechip

(4) Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domainsMolecular CellJanuary 8, 2026Lin Guo, Jacob R. Mann, Jocelyn C. Mauna, Katie E. Copley, Hejia Wang, Jack D. Rubien, Cristian A. Bergmann, Jenny L. Carey, Jessica Merjane, Marilyn Ngo, et al.(RA),Sigma-Aldrich,R2625 Smoothened-Agonist (SAG),Cayman Chemical,11914 SU5402,Cayman Chemical,13182-5 DAPT,Cayman Chemical,13197 TrypLE,Gibco,12604013 DNAseI,Invitrogen,18-047-019 BDNF,PeproTech,450-02 GDNF,PeproTech,450-10 CNTF,PeproTech,450-13 Ascorbic

(5) APOA1 binding protein promotes lymphatic cell fate and lymphangiogenesis by relieving caveolae-mediated inhibition of VEGFR3 signalingNat CommunOctober 21, 2025Jun-Dae Kim, Surbhi Chaudhary, Weiqing Chen, Jonathan Astin, Philip S. Crosier, Pengchun Yu, John P. Cooke, Henry J. Pownall, Hugo J. Bellen, Nhat-Tu Le, et al.flow cytometry analysis. For chemical treatments, cells were treated with a final concentration of 10 µM DAPT (Cat #13197, Cayman chemical) or 50 nM SAR13165 (Cat #28385, Cayman chemical) at day 3 of differentiation and continued

(6) APOE4 promotes cerebrovascular fibrosis and amyloid deposition via a pericyte-to-myofibroblast transitionbioRxivSeptember 16, 2025Braxton R. Schuldt, Dominic Haworth-Staines, Andrea Perez-Arevalo, Diede W.M. Broekaart, Leon Wang, Georgia Gallagher, Grace Rabinowitz, Alison M. Goate, Towfique Raj, Ana C. Pereira, et al.Lipids,Gibco,Cat# 11905031 CHIR99021,Tocris,Cat# 4423 CNTF,Peprotech,Cat# 450-13 DAPT,Cayman,Cat# 13197 Dibutyryl cAMP,Biogems,Cat# 1698950 DMEM,Gibco,Cat# 11965092 DMEM/F12 with GlutaMAX,Gibco,Cat# 10565018 Doxycyline,Millipore,Cat#

(7) Temporal transcriptomic profiling of human three-dimensional neuromuscular co-culturesBiology OpenSeptember 15, 2025Neha Jadhav Giridhar, Bita Hambrecht, Maren Schenke, Bettina Seeger, Thorsten Bischler, Michael Briese, Patrick Lüningschrörtert-Butyl(2S)-2-[[(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoyl]-amino]-2 phenylacetate (DAPT) (Cayman Chemical Company, 13197) for at least 14 days. Differentiation of hiPSC line#2 into MNs MNs derived from the previously used

(8) Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockoutiScienceJuly 18, 2025Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton R. Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt, Joel W. BlanchardL-ascorbic acid (Fisher Scientific BP351), 100 μM dibutyryl cAMP (Biogems 1698950), and 10 μM DAPT (Cayman 13197). After 35 days, organoids were transferred to ultra-low attachment plates (Corning 3516), with about

(9) Integrating collecting systems in human kidney organoids through fusion of distal nephron to ureteric budCell stem cellJuly 3, 2025Shi M, Crouse B, Sundaram N, Pode Shakked N, Thorner K, King NM, Dutta P, Ester L, Zhang W, Govindarajah V, et al.(recombinant human),PeproTech,Cat# 120-05ET CHIR99021,Cayman Chemical,Cat# 13122 DAPT,Cayman Chemical,Cat# 13197 Doxycycline hyclate,Sigma Aldrich,Cat# D9891-1G FGF2 (recombinant human),PeproTech,Cat# 100-18B FGF9

(10) Liver portal fibroblasts induce the functions of primary human hepatocytes in vitroCommunications biologyMay 9, 2025Brown GE, Bodke VV, Ware BR, Khetani SR.were treated with 25 µM N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine t-butyl ester (DAPT, 13197, Cayman Chemical Company, Ann Arbor, MI), a gamma-secretase inhibitor, dissolved in dimethyl-sulfoxide

(11) IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological ConditionsEndocrinologyMarch 24, 2025Wenyuan He, Neruja Loganathan, Denise D Belshaminhibitors in addition to LDN193189 and SB431542. From day 9 to day 16, 10μM DAPT (Cayman Chemicals, 13197), a gamma secretase inhibitor, was used to allow the cells to exit the cell cycle in the presence of

(12) Pre-clinical safety and efficacy of human induced pluripotent stem cell-derived products for autologous cell therapy in Parkinson's diseaseCell stem cellMarch 6, 2025Jeon J, Cha Y, Hong YJ, Lee IH, Jang H, Ko S, Naumenko S, Kim M, Ryu HL, Shrestha Z, et al.Solutions,Cat#210102 SB431542,Cayman Chemical,Cat#13031 CHIR99021,Cayman Chemical,Cat#13122 DAPT,Cayman Chemical,Cat#13197 Boc-D-FMK,Cayman Chemical,Cat#16118 D-amphetamine,Cayman Chemical,Cat#26204 Matrigel® hESC-qualified

(13) Cholesterol-mediated Lysosomal Dysfunction in APOE4 Astrocytes Promotes α-Synuclein Pathology in Human Brain TissuebioRxivFebruary 14, 2025Louise A. Mesentier-Louro, Camille Goldman, Alain Ndayisaba, Alice Buonfiglioli, Rikki B. Rooklin, Braxton R. Schuldt, Abigail Uchitelev, Vikram Khurana, Joel W. BlanchardLipids,Gibco,Cat# 11905031 CHIR99021,Tocris,Cat# 4423 CNTF,Peprotech,Cat# 450-13 DAPT,Cayman,Cat# 13197 Dibutyryl cAMP,Biogems,Cat# 1698950 DMEM,Gibco,Cat# 11965092 DMEM/F12 with GlutaMAX,Gibco,Cat# 10565018 Doxycyline,Millipore,Cat#

(14) Opposing roles of p38α-mediated phosphorylation and PRMT1-mediated arginine methylation in driving TDP-43 proteinopathyCell reportsJanuary 28, 2025Aikio M, Odeh HM, Wobst HJ, Lee BL, Chan Ú, Mauna JC, Mack KL, Class B, Ollerhead TA, Ford AF, et al.Retinoic Acid,Sigma-Aldrich,Cat #R2625 Smoothened-Agonist (SAG),Cayman Chemical,Cat# 11914 DAPT,Cayman Chemical,Cat# 13197 BDNF,PeproTech,Cat # 450-02 GDNF,PeproTech,Cat # 450-10 CNTF,PeproTech,Cat # 450-13 Ascorbic acid,Sigma-Aldrich,Cat

(15) Activity-dependent COX-2 proteolysis modulates aerobic respiration and proliferation in a prostaglandin-independent manneriScienceDecember 20, 2024Liat Hagit Hartal-Benishay, Sharon Tal, Amal Abd Elkader, Omar Ehsainieh, Ranin Srouji-Eid, Tali Lavy, Oded Kleifeld, Martin Mikl, Liza Barki-Harrington,Cayman Chemical,90310 Complete Protease Inhibitor Cocktail,Merck Millipore,11697498001 DAPT (GSI-IX),Cayman Chemical,13197 Deoxycholic acid,Sigma,D2510 E64,Sigma Aldrich,E3132 EDTA sodium salt,J.T. Baker,8993–01 Epidermal

(16) Mycb and Mych stimulate Müller glial cell reprogramming and proliferation in the uninjured and injured zebrafish retinaDevelopmentJuly 15, 2024Mi-Sun Lee, Jonathan Jui, Aresh Sahu, Daniel Goldmanduration of the experiment. In some instances, a single 1 h heat shock was given. DAPT (Cayman Chemical, 13197) was used to inhibit Notch signaling and γ-secretase activity. DAPT was prepared in DMSO as a 10 mM

(17) Genetically Encoded and Modular SubCellular Organelle Probes (GEM-SCOPe) reveal lysosomal and mitochondrial dysfunction driven by PRKN knockoutbioRxivJuly 3, 2024Camille Goldman, Tatyana Kareva, Lily Sarrafha, Braxton R. Schuldt, Abhishek Sahasrabudhe, Tim Ahfeldt, Joel W. BlanchardL-ascorbic acid (Fisher Scientific BP351), 100 μM dibutyryl cAMP (Biogems 1698950), and 10 μM DAPT (Cayman 13197). After 35 days, organoids were transferred to ultra-low attachment plates (Corning 3516), with about

(18) ID factors regulate the ability of Müller glia to become proliferating neurogenic progenitor‐like cellsGliaJuly 1, 2024Olivia B. Taylor, Snehal P. Patel, Evan C. Hawthorn, Heithem M. El‐Hodiri, Andy J. Fischer,R&D System,3718-FB 5-Ethynyl-2'-deocyiridine (EdU),2.3 μg,ThermoFisher,900584 AGX51,10 μg,MedChemExpress,HY-129241 DAPT,45 ng,Cayman Chem,13197 SC144,5 μg,Cayman Chem,29714 IL-1b,200 ng,ThermoFisher,RMIL1BI Pharmacological Compounds

(19) Elevated parkinsonism pathological markers in dopaminergic neurons with developmental exposure to atrazineScience of The Total EnvironmentJanuary 15, 2024Han Zhao, Junkai Xie, Shichen Wu, Xihui Zhao, Oscar F. Sánchez, Sehong Min, Jean-Christophe Rochet, Jennifer L. Freeman, Chongli YuanCat # 100–36E), 0.5 mM dibutyryl-cAMP (dbcAMP) (Sigma, Cat # D0260), and 10 μM DAPT (Cayman, Cat # 13197) in Neurobasal medium supplemented with B27 minus vitamin A (Supplement Table S1 (Supporting Information)).

(20) Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson’s diseaseScience AdvancesJanuary 12, 2024Qian Wang, Minghui Wang, Insup Choi, Lily Sarrafha, Marianna Liang, Lap Ho, Kurt Farrell, Kristin G. Beaumont, Robert Sebra, Claudia De Sanctis, et al.N-[2S-(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine, 1,1-dimethylethyl ester (DAPT) (10 μM; Cayman Chemical, #13197), ascorbic acid (0.2 mM; Fisher BioReagents, #BP351), and Dibutyryl-cAMP,N6,2′-O-Dibutyryladenosine-3′,5′-cyclic

Be the First to Write a Review!

Description

Cayman Chemical

Citations (43)

Reviews

DAPT from Cayman Chemical

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map