Description
An HDAC inhibitor (IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively); selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all); inhibits Nampt (IC50 = 2.1 µM); inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 µM); reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models at 12.5, 25, and 50 mg/kg