Description
A potent inhibitor of the generation of phosphatidic acid (IC50 = 0.6 µM) from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock; suppresses the production of the proinflammatory cytokine IFN-γ, inhibits IL-12 signaling, and enhances glucose-stimulated β-cell insulin secretion; reduces the onset of diabetes in a non-obese diabetic mouse model