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YM-58483
YM-58483 from Cayman Chemical
Be the first to write a review!
Citations:
(4)
Supplier Page
Supplier Page from
Cayman Chemical for
YM-58483
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Description
A potent inhibitor of calcium release-activated calcium channels in lymphocytes (IC50 = 100 nM); also inhibits lung IL-4 and CysLT generation in animal models of asthma
Product Specs
Company Info
Citations
Reviews
Product Specs
Item
YM-58483
Company
Cayman Chemical
Price
$291.00
Supplier Page
View Company Product Page
Catalog Number
13246
Research Area
Adaptive Immunity, Asthma, Calcium Mobilization, Cell Biology, Cell Signaling, Immunology & Inflammation, Inflammatory Lipid Mediators, Innate Immunity, Leukotrienes, Pulmonary Diseases
Format
A crystalline solid
Molecular Weight
421.3
Purity
≥98%
Storage
-20
Formula
C15H9F6N5OS
Origin
USA
Type
Inhibitors
Quantity
10 mg
Specifications/Features
Ki, IC, EC, or working concentration
: IC50: 100 nM
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Cayman Chemical
Cayman Chemical Company 1180 East Ellsworth Road
Ann Arbor
,
Michigan
48108
United States
Phone
: (800) 364-9897
(734) 971-3640
Company Profile
Website:
http://www.caymanchem.com/
Citations (4)
(1)
Microbial sensing through the non-canonical inflammasome modulates airway type 2 immunity
Front Immunol
March 16, 2026
Olivier Bernard, Sheyla Yamato, Oluwaferanmi Bello, Raquel Alvarez, Carter J. Supple, Louis Z. Sharp, Jahanvi Kumar, Maya E. Kotas, Erin D. Gordon
OptiMEM (Thermo). Papain (1 unit/ml, Worthington, LS003124). BTP2 (10 μM,
Cayman Chemical
,
YM-58483
, cat
13246
), calcium chloride (1 mM) or
Trametinib
(10 μM
MedChemExpress
, cat
HY-10999
) were added as indicated.
(2)
The photoswitchable cannabinoid azo ‐ HU308 enables optical control of Ca 2+ dynamics in INS ‐1 β‐cells via off‐target effects on TRPC channels
FEBS Open Bio
November 2, 2025
Alexander E. G. Viray, James A. Frank
SKF 96365 hydrochloride
(
Cayman Chemical
, #
10009312
),
ML‐204
(
Cayman Chemical
, #
15626
),
YM‐58483
(
Cayman Chemical
, #
13246
), and
Pyr 10
(
Tocris
, #6941) were obtained from commercial suppliers. Compounds were dissolved as stock
(3)
Store-operated calcium entry facilitates LPS-induced superoxide anion-dependent macrophage extracellular traps
Open Biol
July 9, 2025
Thang Ngoc Nguyen, Tzu-Chien Lin, Waratchaya Chimphlee, Kon Xuen Siew, Naphatsawan Vongmanee, Shih-Chuan Hsiao, Sarinporn Visitsattapongse, Wen-Tai Chiu
GdCl3 (Sigma, G7532), the SOCE
inhibitors
2 μM SKF96365 (Cayman, 10 009 312) and 10 μM YM58483 (
Cayman
,
13246
) and the superoxide anion scavenger 5 μM thymoquinone (TQ; Sigma, AL-274666) were added for 30 min.
(4)
Orai1 is an Entotic Ca(2+) Channel for Non-Apoptotic Cell Death, Entosis in Cancer Development
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
May 1, 2023
Lee AR, Park CY.
Chloride) (
Sigma–Aldrich
, 439770), AnCoA4 (Sigma–Aldrich, 532999), YM58483 (
Cayman Chemical Company
,
13246
), SKF96365 (
Cayman Chemical Company
,
10009312
),
2‐APB
(
Cayman Chemical Company
, 17146), Heparin (
Sigma–Aldrich
,
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YM-58483 from Cayman Chemical
Supplier Page
View Company Product Page
$291.00
Product Specs
Company Info
Citations
Reviews
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