Gefitinib from Cayman Chemical

An EGFR inhibitor (IC50s = 0.023-0.079 µM); inhibits colony formation of GEO colon, ZR-75-1 and MCF-10A breast, and OVCAR-3 ovarian cancer cell lines in soft agar assays (IC50s = 0.2-0.4 µM); induces apoptosis and inhibits EGFR autophosphorylation in the same cells from 0.1-1 µM; reduces tumor volume and increases survival in a GEO mouse xenograft model at 1.25, 2.5, and 5 mg/kg