Description
A SIRT1 inhibitor (IC50 = 0.098 µM); selective for SIRT1 over SIRT2, and SIRT3 (IC50s = 19.6 and 48.7 µM, respectively) and CYP3A4, CYP2D6, CYP2C9, CYP2C19, and CYP1A2 at 1 µM; induces cell cycle arrest at the G1 phase in MCF-7 cells at 50 µM