MS-275 from Cayman Chemical

An HDAC1 and HDAC3 inhibitor (IC50s = 0.3 and 8 µM, respectively); selective for HDAC1 and HDAC3 over HDAC8 (IC50 = >100 µM); decreases the proliferation of A2780, Calu-3, HL-60, and K562 cells (IC50s = 0.0415, 0.195, 0.212, and 0.589 µM, respectively); induces cell cycle arrest at the G1 phase in A2780 cells at 1 µM; decreases tumor volume and increases intratumoral histone H4 acetylation in an HT-29 colon cancer mouse xenograft model at 49 mg/kg per day