IBMX from Cayman Chemical

Product Specs
ItemIBMX
CompanyCayman Chemical
Price $81.00Supplier Page View Company Product Page
Catalog Number13347
Research AreacAMP Signaling, Cell Biology, Cell Signaling, cGMP Signaling
FormatA crystalline solid
Molecular Weight222.3
Purity≥98%
Storage-20
FormulaC10H14N4O2
OriginCAN
TypeInhibitors
Quantity250 mg

Specifications/Features

Ki, IC, EC, or working concentration: IC50: 19 µM for PDE1
IC50: 50 µM for PDE2
IC50: 18 µM for PDE3
IC50: 13 µM for PDE4
IC50: 32 µM for PDE5
IC50: 7 µM for PDE7
IC50: 50 µM for PDE11

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Mast cell-specific CysLT2 receptor signaling inhibits cysteinyl leukotriene-dependent mast cell activation and type 2 allergic lung inflammationCell ReportsJanuary 27, 2026Jun Nagai, Madeline M. Hastings, Airi Nishida, Sreyashi Majumdar, Kendall Zaleski, Sofia A. Marshall, Junrui Lin, Mira A.S. Saliman, Yumi Tani, Yamato Murakami, et al.Bucladesine (sodium salt),Cayman Chemical,14408 (−)-Isoproterenol hydrochloride,Sigma-Aldrich,I6504-100MG IBMX,Cayman Chemical,13347 HAMI3379,Cayman Chemical,10580 MK571,Cayman Chemical,10029 ESI-09,Cayman Chemical,19130 Montelukast (sodium salt

(2) Mitochondrial membrane junction-mediated ATP channeling drives activity-dependent glucose metabolismbioRxivDecember 19, 2025Dengbao Yang, Gemma Molinaro, Nadine Nijem, Chuanhai Zhang, Dylen Penny, Meijuan Bai, Mei-Jung Lin, Xiaodong Wen, Salvador Pena, Janaka Wansapura, et al.manufacturer’s protocol. To inhibit cAMP hydrolysis, 250 μM 3-isobutyl-1-methylxanthine (IBMX) (Cayman, 13347) was included in NE samples. For lactate measurement, the brown adipocyte suspensions at indicated time

(3) BeadBuddy: user-friendly, nanometer-scale registration of single-molecule imaging databioRxivNovember 30, 2025Finnegan T Clark, Peter H Whitney, Néstor Saiz, Angelina Ziarno, Timothée Lionnetwith 10% FBS, 1X pen/strep, 250nM Dexamethasone (Sigma: D4902), 500uM IBMX (Cayman Chemical Company: 13347), 1uM Rosiglitazone (Sigma: R2408), and 5mg/ml Insulin (Santa Cruz: sc-360248). Media was changed daily

(4) Nouveau Benzo-Mimetics of 17R-Resolvin D2 are Potent Resolution Agonists for InflammationiScienceNovember 22, 2025Charles N. Serhan, Nan Chiang, Mélissa Simard, Robert Nshimiyimana, Ana R. Rodriguez, Seok Joon Mun, Daniel Irimia, Bernd W. Spur,Molecular Probes,Cat#B35000 Dulbecco’s Phosphate Buffered Saline (DPBS),Thermo Fisher Scientific,Cat#14040-133 IBMX,Cayman Chemical,Cat#13347 Cell TraceTM Carboxyfluorescein succinimidyl ester (CFSE),ThermoFisher Scientific,Cat#C34554 Hoechst

(5) The microRNA miR-30a blocks adipose tissue fibrosis accumulation in obesityThe Journal of clinical investigationAugust 1, 2025Saha PK, Sharp R, Cox AR, Habib R, Bolt MJ, Felix JB, Ramirez Bustamante CE, Li X, Jung SY, Kim KH, et al.(Thermo Fisher Scientific, 10565-018), 10% FBS, with 0.250 mM isobutylmethylxanthine (MilliporeSigma, 13347), 1 mM rosiglitazone (Cayman Chemical Co., 71740), 1 mM dexamethasone (Tocris Biosciences, 1126), 850

(6) N-acetylaspartate from fat cells regulates postprandial body temperatureNature MetabolismJuly 23, 2025Jessica B. Felix, Pradip K. Saha, Evelyn L. de Groot, Lin Tan, Robert Sharp, Elizabeth S. Anaya, Yafang Li, Holly Quang, Nooshin Saidi, Layla Abushamat, et al.(Thermo Fisher #10565-018), 10% dialysed FBS (Gibco #A3382001), 0.250 mM isobutylmethylxanthine (Sigma #13347), 1 μM rosiglitazone (Cayman Chemical #71740), 1 μM dexamethasone (Tocris Biosciences #1126), 850 nM

(7) Multiple cAMP/PKA complexes at the STIM1 ER/PM junction specified by E-Syt1 and E-Syt2 reciprocally gates ANO1 (TMEM16A) via Ca2+Nat CommunApril 9, 2025Wei-Yin Lin, Woo Young Chung, Seonghee Park, Ava Movahed Abtahi, Benjamin Leblanc, Malini Ahuja, Shmuel MuallemμM forskolin (Cayman Chemical, 11018) and 10 μM 3-isobutyl-1-methylxanthine (IBMX, Cayman Chemical, 13347) in a perfused bath solution. H89 was obtained from (Sigma-Aldrich, 371962). The bath solution contained

(8) Phosphatases control the duration and range of cAMP/PKA microdomainsFunction (Oxf)March 24, 2025Filippo Conca, Doruk Kaan Bayburtlu, Mauro Vismara, Nicoletta C Surdo, Alessandra Tavoni, Leonardo Nogara, Adamo Sarra, Stefano Ciciliot, Giulietta Di Di Benedetto, Liliana F Iannucci, et al.and Methods Reagents Forskolin (FSK, Cat. No. 11018), 3-isobutyl-1-methylxantine (IBMX, Cat. No. 13347), and H-89 dihydrochloride (H-89, Cat. No. 10010556) were purchased from Cayman Chemical (USA). Dimethyl sulfoxide (DMSO

(9) Distinct cAMP regulation in scleroderma lung and skin myofibroblasts governs their dedifferentiation via p38α inhibitionbioRxivMarch 1, 2025Jared D. Baas, John Varga, Carol Feghali-Bostwick, Marc Peters-Golden, Sean M. Fortierpan-PDE inhibitor IBMX (500 μM) were purchased from Cayman Chemicals (14010, 13740, 15966, 11129, 18272, 13347). The pan-p38 inhibitor SB203580 (20 μM) and p38α inhibitor VX-702 (50 μM) were purchased from Cayman Chemicals

(10) A conserved transcription factor regulatory program promotes tendon fateDevelopmental CellDecember 1, 2024Xubo Niu, Delmy L. Melendez, Suyash Raj, Junming Cai, Dulanjalee Senadeera, Joseph Mandelbaum, Ilya A. Shestopalov, Scott D. Martin, Leonard I. Zon, Thorsten M. Schlaeger, et al.,Cayman Chemical,11018 Colforsin,Cayman Chemical,11214 8-Bromo-cAMP,Sigma,23583–48-4 IBMX,Cayman Chemical,13347 H-89,Cayman Chemical,10010556 ESI-09,Cayman Chemical,19130 L-cis-Diltiazem HCl,Enzo,BML-CA207–0005 66615,Tocris,5661 CBP112,Cayman Chemical

(11) A potent proresolving mediator 17R-resolvin D2 from human macrophages, monocytes, and salivaScience AdvancesNovember 22, 2024Mélissa Simard, Robert Nshimiyimana, Nan Chiang, Ana R. Rodriguez, Bernd W. Spur, Charles N. Serhancells) were plated onto 24-well plates (0.2 × 106 cells per well) and incubated with IBMX (50 μM; no. 13347, Cayman Chemical, Ann Arbor, MI) for 10 min, followed by RvD2, 17R-RvD2 (0.01 to 100 nM), or vehicle

(12) Phosphoproteomics Reveals Selective Regulation of Signaling Pathways by Lysophosphatidic Acid Species in MacrophagesCellsMay 9, 2024Dietze R, Szymanski W, Ojasalu K, Finkernagel F, Nist A, Stiewe T, Graumann J, Müller R.stimulation with 5 µM LPA or solvent, cells were treated with the cAMP phosphodiesterase inhibitor IBMX (13347, Cayman Chemicals, Ann Arbor, MI, USA) at a concentration of 0.1 mM for 15 min. Optical density readings

(13) Parasympathetic neurons derived from human pluripotent stem cells model human diseases and developmentCell stem cellMay 2, 2024Wu HF, Saito-Diaz K, Huang CW, McAlpine JL, Seo DE, Magruder DS, Ishan M, Bergeron HC, Delaney WH, Santori FR, et al.fed with the differentiation medium containing DMEM (Gibco, 11965118), 10 % FBS, 0.5 mM IBMX (Cayman, 13347), 1 μM dexamethasone (Sigma, D2915), and 10 μg/ml insulin (Sigma, I9278). From day 3–6, cells were fed

(14) B56δ long-disordered arms form a dynamic PP2A regulation interface coupled with global allostery and Jordan’s syndrome mutationsProceedings of the National Academy of SciencesJanuary 2, 2024Cheng-Guo Wu, Vijaya K. Balakrishnan, Ronald A. Merrill, Pankaj S. Parihar, Kirill Konovolov, Yu-Chia Chen, Zhen Xu, Hui Wei, Ramya Sundaresan, Qiang Cui, et al.treated with 10 µM forskolin (Fsk; Sigma: 344270-10MG) and 1 mM isobutylmethyxanthine (IBMX; Cayman:13347) to stimulate cellular cAMP/PKA. The cells were harvested at the indicated time following stimulation

(15) Fingerprinting heterocellular β-adrenoceptor functional expression in the brain using agonist activity profilesFrontiers in Molecular BiosciencesAugust 17, 2023Rachel A. Matt, Frederick G. Westhorpe, Rosemary F. Romuar, Payal Rana, Joel R. Gever, Anthony P. Fordsolution of HTRF Stimulation Buffer 1 (Cisbio/Perkin Elmer 64SB1FDC) containing 500 μM IBMX (Cayman 13347) and 5 μM tulobuterol was added to each well with a VIAFLO pipette. The cell plate was sealed with clear

(16) Fucosylated glycoproteins and fucosylated glycolipids play opposing roles in cholera intoxicationbioRxivAugust 3, 2023Atossa C. Ghorashi, Andrew Boucher, Stephanie A. Archer-Hartmann, Nathan B. Murray, Rohit Sai Reddy Konada, Xunzhi Zhang, Chao Xing, Parastoo Azadi, Ulf Yrlid, Jennifer J. KohlerDMSO. 1-Methyl-3-Isobutylxanthine (IBMX, ≥ 98% pure) was purchased from Cayman Chemicals (catalog no. 13347); stock concentrations were made at 50 mM in DMSO. Ro 20-1724 [4-(3-butoxy-4-methoxy-benzyl) imidazolidone]

(17) Lipid droplets are a metabolic vulnerability in melanomaNature communicationsJune 2, 2023Lumaquin-Yin D, Montal E, Johns E, Baggiolini A, Huang TH, Ma Y, LaPlante C, Suresh S, Studer L, White RM.attachment, media was aspirated, and fresh media was added with either DMSO, 200 µM IBMX (Cayman Chemical, 13347), or 20 µM Forskolin (EMD Millipore, 344270). Cells were incubated in drugs for 72 h and then harvested

(18) Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzymebioRxivApril 9, 2023Cheng-Guo Wu, Vijaya K. Balakrishnan, Pankaj S. Parihar, Kirill Konovolov, Yu-Chia Chen, Ronald A Merrill, Hui Wei, Bridget Carragher, Ramya Sundaresan, Qiang Cui, et al.were treated with 10uM forskolin (Fsk; Sigma: 344270–10MG) and 1mM isobutylmethyxanthine (IBMX; Cayman:13347) to stimulate cellular cAMP/PKA. The cells were harvested at the indicated time following stimulation

(19) A rare human variant that disrupts GPR10 signalling causes weight gain in miceNature communicationsMarch 15, 2023Talbot F, Feetham CH, Mokrosiński J, Lawler K, Keogh JM, Henning E, Mendes de Oliveira E, Ayinampudi V, Saeed S, Bonnefond A, et al.incubated in 30 μL PBS supplemented with 1 mM 3-isobutyl-1-methylxanthine (IBMX, Cayman Chemical, 13347) for 30 min prior to stimulation with an agonist. Cells were stimulated with serial dilutions of PrRP-31

(20) O-GlcNAc glycosylation orchestrates fate decision and niche function of bone marrow stromal progenitorseLifeMarch 2, 2023Zhang Z, Huang Z, Awad M, Elsalanty M, Cray J, Ball LE, Maynard JC, Burlingame AL, Zeng H, Mansky KC, et al.(TMG),Biosynth,MD08856, "Chemical compound, drug",Doxycycline food,Bio-Serv,S3888, "Chemical compound, drug",IBMX,CAYMAN,13347, "Chemical compound, drug",Dexamethasone,Sigma,D4902, "Chemical compound, drug",Insulin,Sigma,91077

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IBMX from Cayman Chemical

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