Vacuolin-1 from Santa Cruz Biotechnology, Inc.

Product Specs
ItemVacuolin-1
CompanySanta Cruz Biotechnology, Inc.
Price $260.00Supplier Page View Company Product Page
Catalog Numbersc-216045
Quantity10 mg
TypeBiochemical Reagents
Molecular Weight577.42

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Santa Cruz Biotechnology, Inc.

10410 Finnell Street

Dallas, Texas 75220

United States

Phone: 1-800-457-3801
831-457-3801

Company Profile

Website: http://www.scbt.com/

(1) TRPML1 suppresses pulmonary fibrosis by limiting collagen and elastin depositionThe EMBO JournalFebruary 19, 2026Eva-Maria Weiden, Zala Serianz, Yvonne Klingl, Simone Jörs, Dawid Jaślan, Marco Keller, Sandra Prat Castro, Mane Mkhitaryan, Aicha Jeridi, Daria Briukhovetska, et al.compounds at 37 °C and 5% CO₂ prior to recordings. Vacuolin was purchased from Santa Cruz Biotechnology (sc-216045). All compounds were washed out before patch-clamp experiments. Recordings were conducted at room temperature

(2) Human variation impacting MCOLN2 restricts Salmonella Typhi replication by magnesium deprivationCell GenomMay 10, 2023Gibbs KD, Wang L, Yang Z, Anderson CE, Bourgeois JS, Cao Y, Gaggioli MR, Biel M, Puertollano R, Chen CC, et al.TRPML2-YFP,Grimm et al.58,– Transfection reagent TurboFect,Thermo Fisher,R0531 Vacuolin,Santa Cruz,sc-216045 "PI(3,5)P2",AG Scientific,P-1123 ML2-SA1,Macro Keller and Franz Bracher,– ,, Critical commercial

(3) Cell-Type-Dependent Dissolution of CuO Nanoparticles and Efflux of Cu Ions following Cellular InternalizationEnvironmental science & technologySeptember 6, 2022Wang X, Wang WX.

(4) Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophyHuman molecular geneticsMarch 3, 2022Smith SJ, Fabian L, Sheikh A, Noche R, Cui X, Moore SA, Dowling JJ.

(5) Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient miceNature communicationsJanuary 14, 2022Spix B, Butz ES, Chen CC, Rosato AS, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, et al.

(6) Synergistic effects of autophagy/mitophagy inhibitors and magnolol promote apoptosis and antitumor efficacyActa pharmaceutica Sinica. BDecember 1, 2021Tang Y, Wang L, Yi T, Xu J, Wang J, Qin JJ, Chen Q, Yip KM, Pan Y, Hong P, et al.(V116), and bovine serum albumin (BSA, A2153) were purchased from Sigma–Aldrich (USA). Vacuolin-1 (sc-216045) was purchased from Santa Cruz Biotechnology (USA). Ac220 (HY-13001), hydroxychloroquine (HCQ, HY-B1370),

(7) Vesicular formation regulated by ERK/MAPK pathway mediates human erythroblast enucleationBlood advancesNovember 23, 2021An C, Huang Y, Li M, Xue F, Nie D, Zhao H, Chen L, Yazdanbakhsh K, Sun L, Jiang Z, et al.

(8) TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degenerationLife science allianceAugust 1, 2021Li Y, Schön C, Chen CC, Yang Z, Liegl R, Murenu E, Schworm B, Klugbauer N, Grimm C, Wahl-Schott C, et al.been described previously in detail (48). In brief, the cells were treated with vacuolin (Cat. no. sc-216045; Santa Cruz Biotechnology) at 37°C and 5% CO2 for 1 h. Vacuolin was washed out at least 10 min before

(9) The Kv1.3 ion channel acts as a host factor restricting viral entryFASEB journal : official publication of the Federation of American Societies for Experimental BiologyFebruary 1, 2021Lang Y, Li F, Liu Q, Xia Z, Ji Z, Hu J, Cheng Y, Gao M, Sun F, Shen B, et al.

(10) Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylationNeurobiology of diseaseNovember 1, 2020Kuwahara T, Funakawa K, Komori T, Sakurai M, Yoshii G, Eguchi T, Fukuda M, Iwatsubo T.

(11) TRPML2 is an osmo/mechanosensitive cation channel in endolysosomal organellesScience advancesNovember 1, 2020Chen CC, Krogsaeter E, Butz ES, Li Y, Puertollano R, Wahl-Schott C, Biel M, Grimm C.and 5% CO2. YM201636 was obtained from Chemdea (CD0181), and vacuolin from Santa Cruz Biotechnology (sc-216045). Compounds were washed out before patch-clamp experimentation. Alveolar macrophages were used for experiments

(12) The Lysosomotropic Activity of Hydrophobic Weak Base Drugs is Mediated via Their Intercalation into the Lysosomal MembraneCellsApril 27, 2020Stark M, Silva TFD, Levin G, Machuqueiro M, Assaraf YG.

(13) Bile acids and ceramide overcome the entry restriction for GII.3 human norovirus replication in human intestinal enteroidsProceedings of the National Academy of Sciences of the United States of AmericaJanuary 21, 2020Murakami K, Tenge VR, Karandikar UC, Lin SC, Ramani S, Ettayebi K, Crawford SE, Zeng XL, Neill FH, Ayyar BV, et al.

(14) Endothelial Cells Exhibit Two Waves of P-selectin Surface Aggregation Under Endotoxic and Oxidative ConditionsThe protein journalDecember 1, 2019Barrionuevo N, Gatica S, Olivares P, Cabello-Verrugio C, Simon F.

(15) Lysosomal Ca(2+) release channel TRPML1 regulates lysosome size by promoting mTORC1 activityEuropean journal of cell biologyJune 1, 2019Yang Y, Xu M, Zhu X, Yao J, Shen B, Dong XP.

(16) Autophagy inhibitor Vacuolin-1 interferes with lipid-based small interference RNA deliveryBiochemical and biophysical research communicationsMarch 12, 2019Li T, Yue J, Huang L, Yang M.

(17) Lysosomal Signaling Licenses Embryonic Stem Cell Differentiation via Inactivation of Tfe3Cell stem cellFebruary 7, 2019Villegas F, Lehalle D, Mayer D, Rittirsch M, Stadler MB, Zinner M, Olivieri D, Vabres P, Duplomb-Jego L, De Bont ESJM, et al.

(18) Co-disposition of chitosan nanoparticles by multi types of hepatic cells and their subsequent biological elimination: the mechanism and kinetic studies at the cellular and animal levelsInternational journal of nanomedicineJanuary 1, 2019Jiang LQ, Wang TY, Wang Y, Wang ZY, Bai YT.

(19) Selective agonist of TRPML2 reveals direct role in chemokine release from innate immune cellseLifeNovember 27, 2018Plesch E, Chen CC, Butz E, Scotto Rosato A, Krogsaeter EK, Yinan H, Bartel K, Keller M, Robaa D, Teupser D, et al.Scientific Cat#P-1123 Wortmannin Sigma-Aldrich Cat#W1628 LatrunculinB Sigma-Aldrich Cat#L5288 Vacuolin Santa Cruz Cat# sc-216045 Calcium ionophore A23187 Sigma-Aldrich Cat#C7522 4-Methylumbelliferyl N-acetyl-b-D-glucosaminide Sigma-Aldrich Cat#M2133 RNeasy

(20) Vacuole-inducing compounds that disrupt endolysosomal trafficking stimulate production of exosomes by glioblastoma cellsMolecular and cellular biochemistryFebruary 1, 2018Li Z, Mbah NE, Maltese WA.

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Vacuolin-1 Chemicals

Vacuolin-1 from Santa Cruz Biotechnology, Inc.

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Santa Cruz Biotechnology, Inc.

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Vacuolin-1 from Santa Cruz Biotechnology, Inc.

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