Description
A MRN complex inhibitor; inhibits DSB-induced H2AX phosphorylation (IC50 = 66 µM in X. laevis cell-free extracts); inhibits the exonuclease activity of Mre11 in a cell-free assay at 100 µM; induces cell cycle arrest at the G2 phase in TOSA4 cells and inhibits homology-dependent repair in HEK293 cells in a concentration-dependent manner; reduces tumor growth in an LA-N-5 mouse xenograft model when encapsulated in nanoparticles at 50 mg/kg