SIS3 from Tocris Bioscience, a Bio-Techne Brand | Biocompare.com

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SIS3

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

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Tocris Bioscience, a Bio-Techne Brand for
SIS3

Description

Selective Smad3 inhibitor; inhibits TGF-βR1 signaling

Product Specs
ItemSIS3
CompanyTocris Bioscience, a Bio-Techne Brand
Price $369.00Supplier Page View Company Product Page
Catalog Number5291/10
Quantity10 mg (also 50 mg)
Purity97%
Molecular Weight489.99
Molecule Name1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride
FormulaC28H27N3O3.HCl
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolutioneLifeJune 6, 2022Smith SS, Chu D, Qu T, Aggleton JA, Schneider RA.

(2) Down-Regulation of a Profibrotic Transforming Growth Factor-β1/Cellular Communication Network Factor 2/Matrix Metalloprotease 9 Axis by Triamcinolone Improves Idiopathic Subglottic StenosisThe American journal of pathologyAugust 1, 2021Treviño-Villarreal JH, Reynolds JS, Langston PK, Thompson A, Mitchell JR, Franco RA Jr.

(3) Fludarabine modulates expression of type VII collagen during haematopoietic stem cell transplantation for recessive dystrophic epidermolysis bullosaThe British journal of dermatologyAugust 1, 2021Vanden Oever M, Muldoon D, Mathews W, Tolar J.

(4) Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosisScientific reportsDecember 3, 2020Kim J, Kang W, Kang SH, Park SH, Kim JY, Yang S, Ha SY, Paik YH.

(5) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiationAmerican journal of physiology. Lung cellular and molecular physiologyMay 1, 2018Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O.

(6) Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loopOncotargetDecember 15, 2017Lin S, Sun L, Lyu X, Ai X, Du D, Su N, Li H, Zhang L, Yu J, Yuan S.

(7) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal CellsCell stem cellAugust 4, 2016Mou H, Vinarsky V, Tata PR, Brazauskas K, Choi SH, Crooke AK, Zhang B, Solomon GM, Turner B, Bihler H, et al.

(8) Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cellsJournal of cellular and molecular medicineJune 1, 2013Echeverría C, Montorfano I, Sarmiento D, Becerra A, Nuñez-Villena F, Figueroa XF, Cabello-Verrugio C, Elorza AA, Riedel C, Simon F.

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