Description
• Pull down the active form of Rho
• Colored for easy visualization
Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. Rho, a 21 kDa protein, regulating a variety of biological response pathways that include cell growth, cell transformation and tumor invasion. Like other small GTPases, Rho regulates molecular events by cycling between an inactive GDP-bound form and an active GTP-bound form. In its active (GTP-bound) state, Rho binds specifically to the Rho-binding domain (RBD) of Rhotekin to control downstream signaling cascades