TPCA 1, IkappaB kinase inhibitor from Abcam

Product Specs
ItemTPCA 1, IkappaB kinase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab145522
Quantity10 mg
Purity0.99
TypeInhibitor, inhibitor
Molecule Name5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Human colon stem cells are the predominant epithelial responders to bacterial antigensFront ImmunolOctober 15, 2025Maaike H. De Vries, Claartje A. Meddens, Hemme J. Hijma, Anne-Claire Berrens, Suze A. Jansen, Berend A. P. Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart W. Kuijk, et al.organoids were treated with NFκB-inhibitors: 5µM IMD 0354 (Abcam, ab144823) or 10µM TPCA 1 (Abcam, ab145522). Following the addition of the inhibitors after12h of inhibitors, the organoids were exposed to bacterial

(2) Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediateElifeJune 30, 2025Prateeka Borar, Tapan Biswas, Ankur Chaudhuri, Pallavi T Rao T, Swasti Raychaudhuri, Tom Huxford, Saikat Chakrabarti, Gourisankar Ghosh, Smarajit Polleycompound, drug",Staurosporine,Sigma-Aldrich,S5921,Kinase inhibitor "Chemical compound, drug",TPCA,Abcam,ab145522,IKK inhibitor "Software, algorithm",GROMACS,GROMACS,RRID:SCR_014565, "Software, algorithm",UCSF Chimera,UCSF

(3) Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediateElifeJune 30, 2025Prateeka Borar, Tapan Biswas, Ankur Chaudhuri, Pallavi T Rao, Swasti Raychaudhuri, Tom Huxford, Saikat Chakrabarti, Gourisankar Ghosh, Smarajit Polleycompound, drug",Staurosporine,Sigma-Aldrich,S5921,Kinase inhibitor "Chemical compound, drug",TPCA,Abcam,ab145522,IKK inhibitor "Software, algorithm",GROMACS,GROMACS,RRID:SCR_014565, "Software, algorithm",UCSF Chimera,UCSF

(4) Human colon stem cells are the principal epithelial responders to bacterial antigensbioRxivFebruary 8, 2025Maaike Hillegonda de Vries, Claartje A. Meddens, Hemme J. Hijma, Anne-Claire Berrens, Suze A. Jansen, Berend A.P. Kooiman, Scott Snapper, Hans Clevers, Michal Mokry, Ewart W. Kuijk, et al.organoids were treated with NFκB-inhibitors: 5μM IMD 0354 (Abcam, ab144823) or 10μM TPCA 1 (Abcam, ab145522). Following the addition of the inhibitors after12h of inhibitors, the organoids were exposed to bacterial

(5) A single-cell atlas of conventional central chondrosarcoma reveals the role of endoplasmic reticulum stress in malignant transformationCommunications BiologyJanuary 24, 2024Zezhuo Su, Joshua Wing Kei Ho, Raymond Ching Hing Yau, Ying Lee Lam, Tony Wai Hung Shek, Maximus Chun Fai Yeung, Hongtai Chen, Richard O. C. Oreffo, Kathryn Song Eng Cheah, Kelvin Sin Chi Cheung1:100). Immunocytochemistry staining SW1353 cells with 50% confluence were treated with 10 μM TPCA1 (Abcam, Cat. no. ab145522), 2 μM tunicamycin (SIGMA, Cat. no. T7765), 10 μM TPCA1 + 2 μM tunicamycin, or DMSO (SIGMA, Cat. no.

(6) Induction of natural IgE by glucocorticoidsThe Journal of experimental medicineOctober 3, 2022Lim J, Lin EV, Hong JY, Vaidyanathan B, Erickson SA, Annicelli C, Medzhitov R.Sigma-Aldrich); 1 ng/ml 3,3′,5-triiodo-L-thyronine (T3; T2877; Sigma-Aldrich); or 20 µg/ml TPCA-1 (ab145522; Abcam). An identical 6-h incubation was repeated from 72 to 78 h while maintaining similar cell density.

(7) IFNT-independent effects of intrauterine extracellular vesicles (EVs) in cattleReproduction (Cambridge, England)May 1, 2020Nakamura K, Kusama K, Ideta A, Imakawa K, Hori M.pathway inhibitor, 2-((aminocarbonyl)amino)5-(4-fluorophrnyl)-3-thiophenecarboxaminde (TPCA1) (20 nM, ab145522, Abcam) for 48 h. RNA extraction and quantitative RT-PCR Using the ISOGEN reagent (Nippon Gene, Tokyo,

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TPCA 1, IkappaB kinase inhibitor from Abcam

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TPCA 1, IkappaB kinase inhibitor from Abcam

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