SAG from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemSAG
CompanyTocris Bioscience, a Bio-Techne Brand
Price $221.00Supplier Page View Company Product Page
Catalog Number4366/1
Quantity1 mg (also 10 mg)
Purity98%
Molecular Weight490.06
Molecule Name3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
FormulaC28H28ClN3OS
StorageStore at -20°C

Specifications/Features

Sizes Available: 1 mg (also 10 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) In vitro reconstitution of epigenetic reprogramming in the human germ lineNatureJuly 1, 2024Murase Y, Yokogawa R, Yabuta Y, Nagano M, Katou Y, Mizuyama M, Kitamura A, Puangsricharoen P, Yamashiro C, Hu B, et al.

(2) Characterizing the Neuron-Glial Interactions by the Co-cultures of Human iPSC-Derived Oligodendroglia and NeuronsMethods in molecular biology (Clifton, N.J.)January 1, 2023Vulakh G, Yang X.

(3) Primary cilia on muscle stem cells are critical to maintain regenerative capacity and are lost during agingNature communicationsMarch 17, 2022Palla AR, Hilgendorf KI, Yang AV, Kerr JP, Hinken AC, Demeter J, Kraft P, Mooney NA, Yucel N, Burns DM, et al.

(4) Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small MoleculesMethods in molecular biology (Clifton, N.J.)January 1, 2022Ryu S, Chu PH, Malley C, Braisted J, Ormanoglu P, Huang R, Itkin M, Itkin Z, Shinn P, Klumpp-Thomas C, et al.

(5) Induced pluripotent stem cell-derived motor neurons of CMT type 2 patients reveal progressive mitochondrial dysfunctionBrain : a journal of neurologySeptember 4, 2021Van Lent J, Verstraelen P, Asselbergh B, Adriaenssens E, Mateiu L, Verbist C, De Winter V, Eggermont K, Van Den Bosch L, De Vos WH, et al.maturation. Compounds used included: retinoic acid (R2625-50MG, Sigma Aldrich), smoothened agonist (SAG, 4366/1, Bio-Techne), brain derived neurotrophic factor (BDNF, 450-02, Peprotech), glial cell derived neurotrophic

(6) In Vitro Generation of Posterior Motor Neurons from Human Pluripotent Stem CellsCurr ProtocSeptember 1, 2021Wind M, Tsakiridis A.

(7) Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imagingCommunications biologyJune 24, 2021Tomov ML, O'Neil A, Abbasi HS, Cimini BA, Carpenter AE, Rubin LL, Bathe M.

(8) A weakened interface in the P182L variant of HSP27 associated with severe Charcot-Marie-Tooth neuropathy causes aberrant binding to interacting proteinsThe EMBO journalApril 15, 2021Alderson TR, Adriaenssens E, Asselbergh B, Pritišanac I, Van Lent J, Gastall HY, Wälti MA, Louis JM, Timmerman V, Baldwin AJ, et al.maturation of the motor neurons: retinoic acid (302‐79‐4, Sigma‐Aldrich), smoothened agonist (SAG, 4366/1, Bio‐Techne), γ‐secretase inhibitor (DAPT, 2634/10, Bio‐Techne), and the neurotrophic factors brain‐derived

(9) Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosisNature communicationsDecember 11, 2020Jutzi D, Campagne S, Schmidt R, Reber S, Mechtersheimer J, Gypas F, Schweingruber C, Colombo M, von Schroetter C, Loughlin FE, et al.

(10) Generation of Human Neurons and Oligodendrocytes from Pluripotent Stem Cells for Modeling Neuron-Oligodendrocyte InteractionsJournal of visualized experiments : JoVENovember 9, 2020Assetta B, Tang C, Bian J, O'Rourke R, Connolly K, Brickler T, Chetty S, Huang YA.

(11) Detailed Phenotyping and Therapeutic Strategies for Intronic ABCA4 Variants in Stargardt DiseaseMolecular therapy. Nucleic acidsSeptember 4, 2020Khan M, Arno G, Fakin A, Parfitt DA, Dhooge PPA, Albert S, Bax NM, Duijkers L, Niblock M, Hau KL, et al.

(12) SEM/FIB Imaging for Studying Neural InterfacesDevelopmental neurobiologySeptember 1, 2020Henn I, Atkins A, Markus A, Shpun G, Barad HN, Farah N, Mandel Y.

(13) Electrophysiologic Characterization of Developing Human Embryonic Stem Cell-Derived Photoreceptor PrecursorsInvestigative ophthalmology & visual scienceSeptember 1, 2020Schick R, Farah N, Markus A, Korngreen A, Mandel Y.

(14) In Vitro and In Vivo Development of the Human Airway at Single-Cell ResolutionDevelopmental cellApril 6, 2020Miller AJ, Yu Q, Czerwinski M, Tsai YH, Conway RF, Wu A, Holloway EM, Walker T, Glass IA, Treutlein B, et al.(50 U/mL, R&D Systems, cat. no. 202-IL-010), Smoothened Agonist (SAG; 500 nM, R&D Systems, cat. no. 4366/1), EGF (100 ng/mL, R&D Systems cat. no. 236-EG-200), IFNγ (10 ng/mL, R&D Systems cat. no. CAA31639)

(15) Nek2 kinase displaces distal appendages from the mother centriole prior to mitosisThe Journal of cell biologyMarch 2, 2020Viol L, Hata S, Pastor-Peidro A, Neuner A, Murke F, Wuchter P, Ho AD, Giebel B, Pereira G.

(16) Axon-seq for in Depth Analysis of the RNA Content of Neuronal ProcessesBio-protocolJuly 20, 2019Nijssen J, Aguila J, Hedlund E.

(17) Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodiesAutophagyJune 1, 2019Haidar M, Asselbergh B, Adriaenssens E, De Winter V, Timmermans JP, Auer-Grumbach M, Juneja M, Timmerman V.et al (2017) [36]. Compounds used include: retinoic acid (Sigma Aldrich, 302-79-4), SAG (Bio-Techne, 4366/1), the growth factors BDNF (Immunosource, CSB-EL016134MO) and GDNF (Immunosource, 21-8506-U002), DAPT

(18) Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degenerationAutophagyApril 1, 2019Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, et al.

(19) Super-Obese Patient-Derived iPSC Hypothalamic Neurons Exhibit Obesogenic Signatures and Hormone ResponsesCell stem cellMay 3, 2018Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, et al.

(20) Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM LeukodystrophyFrontiers in molecular neuroscienceJanuary 1, 2018Atzmon A, Herrero M, Sharet-Eshed R, Gilad Y, Senderowitz H, Elroy-Stein O.

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SAG

SAG from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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SAG from Tocris Bioscience, a Bio-Techne Brand

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