Description
COMU 1-[1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino]-uronium hexafluorophosphate morpholinium, 4-[[[(1-cyano-2-ethoxy-2-oxoethylene)amino]oxayk] (dimethylamino)methylene]-hexafluorophosphate (1-) (1:1) (M.W. 428.27) C12H19N4O4F6P CAS 1075198-30-9 A safe and highly efficient coupling reagent requiring only one equivalent of base during bond formation as it liberates morpholine. This helps to minimize concomitant racemization. Non-allergenic. Couplings with COMU can be monitored visually or colorimetrically, the reagent shows excellent solubility in DMF and NMP. A.El-Faham and F.Albericio, J. Org. Chem., 73, 2731 (2008) A.El-Faham et al., Poster P10103-039 presented at the 30th EPS, Helsinki, (2008)