Purmorphamine from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemPurmorphamine
CompanyTocris Bioscience, a Bio-Techne Brand
Price $301.00Supplier Page View Company Product Page
Catalog Number4551/10
Quantity10 mg (also 50 mg)
Purity98%
Molecular Weight520.62
Molecule Name9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
FormulaC31H32N6O2
StorageStore at -20°C

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Inhibition of PHLDA3 expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicityBrain CommunicationsJuly 25, 2024Kornélia Szebényi, Ingrid Vargová, Veselina Petrova, Jana Turečková, George M Gibbons, Monika Řehořová, Mai Abdelgawad, Alexandra Sándor, Dana Marekova, Jessica C F Kwok, et al.supplemented with 500 nM retinoic acid (Abcam, ab120728) and 1 μM purmorphamine (Tocris Biosciences, 4551/10). On Day 14, the cells were detached with 0.5 mM EDTA and transferred to an uncoated flask in fresh

(2) Calcium dysregulation combined with mitochondrial failure and electrophysiological maturity converge in Parkinson's iPSC-dopamine neuronsiScienceJuly 21, 2023Beccano-Kelly DA, Cherubini M, Mousba Y, Cramb KML, Giussani S, Caiazza MC, Rai P, Vingill S, Bengoa-Vergniory N, Ng B, et al.acid,Sigma,Cat#A4544 LDN-193189,Sigma,Cat#SML0559 SB-431542,Bio-Techne,Cat#1614 SHH C24II,Bio-Techne,Cat#1845-SH-500 Purmorphamine,Bio-Techne,Cat#4551/10 FGF8a,Stratech,Cat#16124-HNAE-SIB CHIR-99021,Bio-Techne,Cat#4423 BDNF,Peprotech,Cat#450-02 (db)-cAMP,Sigma,Cat#D0627 hESC-qualified

(3) Generation and characterization of NGLY1 patient-derived midbrain organoidsFrontiers in cell and developmental biologyJanuary 1, 2023Abbott J, Tambe M, Pavlinov I, Farkhondeh A, Nguyen HN, Xu M, Pradhan M, York T, Might M, Baumgärtel K, et al.

(4) Directed differentiation of human pluripotent stem cells into diverse organ-specific mesenchyme of the digestive and respiratory systemsNature protocolsNovember 1, 2022Kishimoto K, Iwasawa K, Sorel A, Ferran-Heredia C, Han L, Morimoto M, Wells JM, Takebe T, Zorn AM.

(5) Dynamic 3D Combinatorial Generation of hPSC-Derived Neuromesodermal Organoids With Diverse Regional and Cellular IdentitiesCurr ProtocOctober 1, 2022Whye D, Wood D, Kim KH, Chen C, Makhortova N, Sahin M, Buttermore ED.

(6) Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's diseaseNature communicationsAugust 16, 2022Schmidt S, Luecken MD, Trümbach D, Hembach S, Niedermeier KM, Wenck N, Pflügler K, Stautner C, Böttcher A, Lickert H, et al.

(7) Genome-wide identification of the genetic basis of amyotrophic lateral sclerosisNeuronMarch 16, 2022Zhang S, Cooper-Knock J, Weimer AK, Shi M, Moll T, Marshall JNG, Harvey C, Nezhad HG, Franklin J, Souza CDS, et al.

(8) Human Pluripotent Stem Cells for High-Throughput Drug Screening and Characterization of Small MoleculesMethods in molecular biology (Clifton, N.J.)January 1, 2022Ryu S, Chu PH, Malley C, Braisted J, Ormanoglu P, Huang R, Itkin M, Itkin Z, Shinn P, Klumpp-Thomas C, et al.

(9) Growth factor mimetics for skin regeneration: In vitro profiling of primary human fibroblasts and keratinocytesArchiv der PharmazieAugust 1, 2021Horinouchi CDS, Oostendorp C, Schade D, van Kuppevelt TH, Daamen WF.

(10) ARP-T1-associated Bazex-Dupré-Christol syndrome is an inherited basal cell cancer with ciliary defects characteristic of ciliopathiesCommunications biologyMay 10, 2021Park HS, Papanastasi E, Blanchard G, Chiticariu E, Bachmann D, Plomann M, Morice-Picard F, Vabres P, Smahi A, Huber M, et al.

(11) Robust single-cell discovery of RNA targets of RNA-binding proteins and ribosomesNature methodsMay 1, 2021Brannan KW, Chaim IA, Marina RJ, Yee BA, Kofman ER, Lorenz DA, Jagannatha P, Dong KD, Madrigal AA, Underwood JG, et al.

(12) Integration of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Neurons into Rat Brain CircuitsBIO-PROTOCOLSeptember 5, 2020Xiling Yin, Ted M Dawson, Valina L Dawsonng/ml, R&D system, catalog number: 1845-SH-025) 23. Purmorphamine (2 μM, R&D system, catalog number: 4551/10) 24. Brain-derived neurotrophic factor (BDNF, 20 ng/ml, PeproTech, catalog number: 450-02) 25. Glial

(13) Transcriptomic and epigenomic dynamics associated with development of human iPSC-derived GABAergic interneuronsHuman molecular geneticsAugust 29, 2020Inglis GAS, Zhou Y, Patterson DG, Scharer CD, Han Y, Boss JM, Wen Z, Escayg A.

(14) IPSC-Derived Neuronal Cultures Carrying the Alzheimer's Disease Associated TREM2 R47H Variant Enables the Construction of an Aβ-Induced Gene Regulatory NetworkInternational journal of molecular sciencesJune 25, 2020Martins S, Müller-Schiffmann A, Erichsen L, Bohndorf M, Wruck W, Sleegers K, Van Broeckhoven C, Korth C, Adjaye J.

(15) Variable Outcomes in Neural Differentiation of Human PSCs Arise from Intrinsic Differences in Developmental Signaling PathwaysCell reportsJune 9, 2020Strano A, Tuck E, Stubbs VE, Livesey FJ.

(16) FGF Modulates the Axial Identity of Trunk hPSC-Derived Neural Crest but Not the Cranial-Trunk DecisionStem cell reportsMay 14, 2019Hackland JOS, Shelar PB, Sandhu N, Prasad MS, Charney RM, Gomez GA, Frith TJR, García-Castro MI.

(17) Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent VitrificationStem cells translational medicineMarch 1, 2019Kaindl J, Meiser I, Majer J, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B.

(18) IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth developmentCell death & diseaseJanuary 25, 2019Yuan X, Cao X, Yang S.

(19) Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell PhenotypesCell stem cellJanuary 3, 2019Lang C, Campbell KR, Ryan BJ, Carling P, Attar M, Vowles J, Perestenko OV, Bowden R, Baig F, Kasten M, et al.Okadaic acid,Abcam,Cat#O7885 LB100,Tocris,Cat#S7537 Cantharidin,Tocris,Cat#1548 LDN-193189,Sigma,Cat#SML0559 SB-431542,Bio-Techne,Cat#1614 SHH C24II,Bio-Techne,Cat#1845-SH-500 Purmorphamine,Bio-Techne,Cat#4551/10 FGF8a,Stratech,Cat#16124-HNAE-SIB CHIR-99021,Bio-Techne,Cat#4423 BDNF,Peprotech,Cat#450-02 GDNF,Peprotech,Cat#450-10 TGFb3,Peprotech,Cat#100-36E DAPT,Abcam,Cat#ab120633 Ascorbic

(20) Generating Human iPSC-Derived Astrocytes with Chemically Defined Medium for In Vitro Disease ModelingMethods in molecular biology (Clifton, N.J.)January 1, 2019Janssen K, Bahnassawy L, Kiefer C, Korffmann J, Terstappen GC, Lakics V, Cik M, Reinhardt P.

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Purmorphamine

Purmorphamine

Purmorphamine from Tocris Bioscience, a Bio-Techne Brand

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Specifications/Features

Tocris Bioscience, a Bio-Techne Brand

Citations (25)

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Purmorphamine from Tocris Bioscience, a Bio-Techne Brand

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