C59, Wnt Antagonist, Wnt signaling pathway inhibitor from Abcam

Product Specs
ItemC59, Wnt Antagonist, Wnt signaling pathway inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab142216
Quantity1 MG, 5 MG
Purity0.97
Typeinhibitor

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) SERCA2 phosphorylation at serine 663 is a key regulator of Ca2+ homeostasis in heart diseasesNature CommunicationsJune 8, 2023Fabrice Gonnot, Laura Boulogne, Camille Brun, Maya Dia, Yves Gouriou, Gabriel Bidaux, Christophe Chouabe, Claire Crola Da Silva, Sylvie Ducreux, Bruno Pillot, et al.for three days, renewed after 2 days. hiPSCs are then treated with 2 μM C59-Wnt antagonist (Abcam, Ab142216) in RPMI 1640 medium supplemented with B27 minus insulin. After five days, cells are switch in RPMI 1640 medium

(2) RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapyeLifeOctober 27, 2021Radaszkiewicz T, Nosková M, Gömöryová K, Vondálová Blanářová O, Radaszkiewicz KA, Picková M, Víchová R, Gybeľ T, Kaiser K, Demková L, et al.inhibition of endogenous Wnt ligands, cells were treated with the 0.5 μM Porcupine inhibitors C-59 (ab142216, Abcam) or 1 μM LGK-974 (1241454, PeproTech). The time points and doses have been chosen based on the

(3) Quantitative Profiling of WNT-3A Binding to All Human Frizzled Paralogues in HEK293 Cells by NanoBiT/BRET AssessmentsACS Pharmacology & Translational ScienceJune 11, 2021Paweł Kozielewicz, Rawan Shekhani, Stefanie Moser, Carl-Fredrik Bowin, Janine Wesslowski, Gary Davidson, Gunnar SchulteMolecular weights of the WNTs were as per supplier’s datasheets. Porcupine inhibitor C59 was from Abcam (#ab142216, Cambridge, UK).57 C59 was dissolved in DMSO at 5 mM and stored at −20 °C. The serial dilutions of WNTs

(4) Reduced WNT5A signaling in melanoma cells favors an amoeboid mode of invasionMolecular OncologyMay 15, 2021Njainday Pulo Jobe, Lisa Åsberg, Tommy AnderssonMunich, Germany, Cat# S1267) or DMSO for the final 24 h of siRNA transfection. For C59 (Abcam, Cat#: ab142216) treatment, HTB63 and WM852 cells were incubated with 1 μm C59 or vehicle (DMSO) control in either collagen

(5) Differentiation of Human Cardiac Atrial Appendage Stem Cells into Adult Cardiomyocytes: A Role for the Wnt Pathway?International Journal of Molecular SciencesMay 30, 2020Leen Willems, Annick Daniëls, Yanick Fanton, Loes Linsen, Lize Evens, Virginie Bito, Jeroen Declercq, Jean-Luc Rummens, Karen Hensen, Marc HendrikxBC, Canada), IWP2 (4 and 20 µM; Sigma Aldrich; I0536, St. Louis, MI, USA), C59 (1 and 5 µM; Abcam; ab142216, Cambridge, UK), XAV939 (2 and 10 µM; Sigma Aldrich; X3004, St. Louis, MI, USA), and IWR1-endo (4 and

(6) Structural insight into small molecule action on FrizzledsNature communicationsJanuary 21, 2020Kozielewicz P, Turku A, Bowin CF, Petersen J, Valnohova J, Cañizal MCA, Ono Y, Inoue A, Hoffmann C, Schulte G.cell exposure. C59 (2-[4-(2-methylpyridin-4-yl)phenyl]-N-[4-(pyridin-3-yl)phenyl]acetamide; Abcam #ab142216; stored as 5 mM solution in aliquots in dimethyl sulfoxide (DMSO; at −20 °C) was used to inhibit porcupine

(7) CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat ModelInternational Journal of Molecular SciencesSeptember 29, 2016Weiwei Lu, Jia Shi, Jinming Zhang, Zhengtao Lv, Fengjing Guo, Hui Huang, Wentao Zhu, Anmin Chenaggrecan neo-epitope 374ARGSV (ab3773), PNCA (ab29), SB202190 (ab120638), U-0126 (ab120241), and C59 (ab142216) were purchased from Abcam (Cambridge, UK). Antibodies for ERK (#9102), phospho-ERK (#4377), JNK (#9258),

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6/25/2019C59 Is an Effective Wnt Antagonist Useful for Wnt-Based Experiments (Abcam) Ab GC59 can be dissolved in DMSO for treatment of human breast cancer cells to determine dependency on Wnt signaling. This can also be a viable option as a positive control for comparison with other ... Read Review

C59, Wnt Antagonist, Wnt signaling pathway inhibitor from Abcam

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C59, Wnt Antagonist, Wnt signaling pathway inhibitor from Abcam

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