5-Azacytidine, DNMT1 inhibitor from Abcam

Product Specs
Item5-Azacytidine, DNMT1 inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab142744
Quantity1 g, 250 mg
TypeInhibitor, inhibitor
Molecule NameAzacitidine

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Abcam

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Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Gene body methylation suppresses intragenic transcription and permits epigenetic inheritance in a cnidarianNature Ecology & EvolutionJune 2, 2026Lan Xu, Richard Heery, Damir Baranasic, Bojan Žunar, Alvaro Segura Campaña, Vladimir Ovchinnikov, Boris Lenhard, Alex de Mendozawere treated with different concentrations of cytidine analogues, including 5-azacytidine (Abcam, no. ab142744), zebularine (Abcam, no. ab141264) and decitabine (Abcam, no. ab120842), using DMSO as a control. Embryos

(2) DNMT1 deficiency promotes pulmonary vascular remodeling in pulmonary hypertension through epigenetic upregulation of BMP7Respiratory ResearchDecember 16, 2025Yong-Bing Wang, Lei Gao, Jia-Xin Wang, Zhe Mei, You-Li Fan, Xuan Gao, Jing Huang, Bin-Feng Sun, Yu-Fei Gao, Na Sun, et al.administered at a concentration of 100 ng/mL for 48 h and the DNMT inhibitor 5-Azacytidine (5-Aza; ab142744, Abcam) was applied at 2 µM for 48 h, with all experiments using cells between passages 2–4 to ensure

(3) Dual targeting of G9a and DNMTs induces antitumor effects in multiple myelomaBlood advancesOctober 14, 2025Nylund P, Garrido-Zabala B, Tziola SI, Mohajershojai T, Berglund H, Muylaert C, Van Hemelrijck LA, Atienza Párraga A, Vasquez L, Jacob J, et al.(catalog no. 317275; Sigma-Aldrich, Merck, Darmstadt, Germany), or 50 to 200 nM AZA (Abcam; catalog no. ab142744, Cambridge, United Kingdom) and 5 to 10 μM A366 (catalog no. 5163; Tocris Bio-Techne, Minneapolis, MN).

(4) Repressive cytosine methylation is a marker of viral gene transfer across divergent eukaryotesMolecular Biology and EvolutionJuly 30, 2025Luke A Sarre, Giselle Azucena Gastellou Peralta, Pedro Romero Charria, Vladimir Ovchinnikov, Alex de Mendozapurchased from CCAP collection. Treatment With Cytidine Analogues DNA demethylation drugs 5-Azacytidine (ab142744 Abcam), decitabine (ab120842), and zebularine (ab141264) were dissolved in DMSO as per manufacturer's

(5) Annelid methylomes reveal ancestral developmental and aging-associated epigenetic erosion across BilateriaGenome BiologyAugust 1, 2024Kero Guynes, Luke A. Sarre, Allan M. Carrillo-Baltodano, Billie E. Davies, Lan Xu, Yan Liang, Francisco M. Martín-Zamora, Paul J. Hurd, Alex de Mendoza, José M. Martín-DuránO. fusiformis were treated with 50 μM zebularine (Abcam: ab141264) and 10 μM 5-azacytidine (Abcam: ab142744) using equivalent volumes of dimethyl sulfoxide (DMSO) as a negative control. Treated and control embryos

(6) Effects of EZH2 inhibitor, trichostatin A, and 5-azacytidine combinatorial treatment on osteogenic differentiation of dental pulp stem cellsHeliyonJune 30, 2024Edit Hrubi, László Imre, Csaba Hegedüssupplemented with 5 μM EZH2i (ab269816; Abcam, Cambridge, UK), 10 μM TSA (ab146598; Abcam), or 1 μM 5-AZA (ab142744; Abcam) alone or in combination. 2.2 Osteogenic differentiation A total of 30,000 cells was seeded

(7) Transient suppression of SUMOylation in embryonic stem cells generates embryo-like structuresCell reportsApril 25, 2023Cossec JC, Traboulsi T, Sart S, Loe-Mie Y, Guthmann M, Hendriks IA, Theurillat I, Nielsen ML, Torres-Padilla ME, Baroud CN, et al.cells were seeded in 6-well plates in serum+Lif medium and treated with 0.1 μM of 5-azacytidine (Abcam #ab142744). Medium was refreshed every day for a total of 5 days of treatment. Generating adherent spheroids ESCs

(8) ARF suppression by MYC but not MYCN confers increased malignancy of aggressive pediatric brain tumorsNature communicationsMarch 3, 2023Mainwaring OJ, Weishaupt H, Zhao M, Rosén G, Borgenvik A, Breinschmid L, Verbaan AD, Richardson S, Thompson D, Clifford SC, et al.demethylation studies, mice were administered daily I.P. injections of 0.2 mg/kg 5-Azacytidine (Abcam, ab142744). For HSP90 inhibition studies, mice were administered daily I.P. injections of 20 mg/kg Onalespib (Selleckchem,

(9) Presenilin 2 N141I mutation induces hyperactive immune response through the epigenetic repression of REV-ERBαNature communicationsApril 13, 2022Nam H, Lee Y, Kim B, Lee JW, Hwang S, An HK, Chung KM, Park Y, Hong J, Kim K, et al.(D0567) and chlorpromazine hydrochloride (C8138) were purchased from Sigma-Aldrich; 5-azacytidine (ab142744) from Abcam; and D-luciferin (E1601) from Promega; PD98059 (9900) from Cell Signaling Technology. Cell culture

(10) LARP1 isoform expression in human cancer cell linesRNA biologyFebruary 1, 2021Schwenzer H, Abdel Mouti M, Neubert P, Morris J, Stockton J, Bonham S, Fellermeyer M, Chettle J, Fischer R, Beggs AD, et al.cultivated in a 10 cm cell culture dishes to 70% confluency. Indicated concentration of 5-Azacytidine (ab142744, Abcam) was added to the cells and medium was replaced daily. Control cells were treated with a respective

(11) 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And ApoptosisCancer Manag ResNovember 8, 2019Jinyuan Chen, Lixiang Wu, Hong Xu, Shubang Chengwere purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences; 5-Azacytidine (100 mg; Ab142744) was purchased from Abcam; The cell culture reagent was prepared from the following reagents: DMEM-high

(12) 5-Aza-CdR Regulates RASSF1A By Inhibiting DNMT1 To Affect Colon Cancer Cell Proliferation, Migration And ApoptosisCancer Management and ResearchNovember 8, 2019Jinyuan Chen, Lixiang Wu, Hong Xu, Shubang Chengwere purchased from the Shanghai Cell Bank of the Chinese Academy of Sciences; 5-Azacytidine (100 mg; Ab142744) was purchased from Abcam; The cell culture reagent was prepared from the following reagents: DMEM-high 9518 Powered

(13) Nc886 is epigenetically repressed in prostate cancer and acts as a tumor suppressor through the inhibition of cell growthBMC CancerDecember 1, 2018Rafael Sebastián Fort et al.treatment DU145, RWPE-1, PC-3 and LNCaP cells were treated for 72 h with 1.5 μmol/L 5-Azacytidine (ab142744, Abcam) and DMSO as control, replacing the medium with freshly added drug every 24 h following manufacturer’s

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5-Azacytidine, DNMT1 inhibitor from Abcam

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5-Azacytidine, DNMT1 inhibitor from Abcam

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