SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor from Abcam

Product Specs
ItemSCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab142089
Quantity1 mg
Purity0.99
Molecule NameSCD1 Inhibitor
TypeInhibitor, inhibitor

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Central inhibition of stearoyl-CoA desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer’s disease mouse modelScientific ReportsApril 2, 2024Laura K. Hamilton, Paule E. H. M’Bra, Sophia Mailloux, Manon Galoppin, Anne Aumont, Karl J. L. FernandesPhysiology core facility of the CHUM Research Center. SCD inhibitor SCD inhibitor used in this study: ab142089 (Abcam, C20H22ClN3O3, 4-(2-Chlorophenoxy)-N-[3 [(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide,

(2) RNA sequencing unravels novel L cell constituents and mechanisms of GLP-1 secretion in human gastric bypass-operated intestineDiabetologiaFebruary 1, 2024Michael G. Miskelly, Andreas Lindqvist, Elena Piccinin, Alexander Hamilton, Elaine Cowan, Bent-Johnny Nergård, Rita Del Giudice, Mtakai Ngara, Luis R. Cataldo, Dmytro Kryvokhyzha, et al.permission granted to the laboratory where the OGTT was performed. A total of 500 μg/kg SCD1 inhibitor (Ab142089, Abcam) or 0.9% NaCl (wt/vol.) was administered orally 1 h pre OGTT to lean C57Bl/6j female mice (n=10),

(3) Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse modelNature CommunicationsDecember 1, 2022Laura K. Hamilton et al.94 °C, 30 s at 62 °C and 45 s at 72 °C. SCD inhibitors Two SCD inhibitors were used in this study: ab142089 (Abcam, C20H22ClN3O3, 4-(2-Chlorophenoxy)-N-[3 [(methylamino)carbonyl]phenyl]-1-piperidinecarboxamide,

(4) Raman microscopy-based quantification of the physical properties of intracellular lipidsCommunications BiologyDecember 1, 2021Masaaki Uematsu, Takao Shimizuwith PBS. To conduct the SCD1 inhibition experiment, HeLa cells were treated with an SCD1 inhibitor (ab142089; Abcam, Cambridge, United Kingdom) with the indicated concentration of free fatty acid(s) for 24 h.

(5) Tumor resistance to ferroptosis driven by Stearoyl-CoA Desaturase-1 (SCD1) in cancer cells and Fatty Acid Biding Protein-4 (FABP4) in tumor microenvironment promote tumor recurrenceRedox biologyJuly 1, 2021Luis G, Godfroid A, Nishiumi S, Cimino J, Blacher S, Maquoi E, Wery C, Collignon A, Longuespée R, Montero-Ruiz L, et al.and 2 weeks for the MDA-MB23 and LLC tumors, respectively. For in vitro experiments, SCD1 Inh (Abcam, ab142089) was dissolved in DMSO at 100 mM and stored at −20. For in vivo studies, SCD1 Inh (DC Chemicals DC5893)

(6) Angiotensin II promotes ovarian cancer spheroid formation and metastasis by upregulation of lipid desaturation and suppression of endoplasmic reticulum stressJournal of Experimental & Clinical Cancer ResearchDecember 1, 2019Qingyu Zhang, Shan Yu, Melody Man Ting Lam, Terence Chuen Wai Poon, Litao Sun, Yufei Jiao, Alice Sze Tsai Wong, Leo Tsz On Leemay prevent necrosis during spheroid formation. To test this hypothesis, we used a SCD1 inhibitor (ab142089, Abcam) to block the related pathway. As expected, the SCD1 inhibitor treatment almost completely abolished

(7) Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson TreatmentMolecular cellMarch 7, 2019Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, et al.cortical neuron treatment with SCD inhibitors SCD inhibitors (HY19762 and HY15700, MedChemexpress) and (ab142089, Abcam) were diluted in DMSO and added to rat cortical neurons at concentrations indicated in figures. Immunoblotting Neuronal

(8) Loss of ULK1 increases RPS6KB1-NCOR1 repression of NR1H/LXR-mediated Scd1 transcription and augments lipotoxicity in hepatic cellsAutophagyJanuary 2, 2017Sinha RA, Singh BK, Zhou J, Xie S, Farah BL, Lesmana R, Ohba K, Tripathi M, Ghosh S, Hollenberg AN, et al.Bioscience, 4247), PF4708671 (Tocris Bioscience, 4032), PBS (SIGMA-ALDRICH, P3813) and SCD1 inhibitor (ABCAM, ab142089). Cell culture AML-12 (CRL-2254) cells were maintained at 37°C in DMEM-F12 1:1 containing 10% fetal

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SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor from Abcam

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Abcam

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SCD1 Inhibitor, SCD1(stearoyl-CoA desaturase 1) inhibitor from Abcam

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