Compound E, gamma;-secretase inhibitor from Abcam

Product Specs
ItemCompound E, gamma;-secretase inhibitor
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab142164
Quantity1 mg, 250 µg
Purity0.99
TypeInhibitor, inhibitor
Molecule Namegamma-Secretase Inhibitor XXI

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) Nonsense-mediated decay masks cryptic splicing events caused by TDP-43 lossbioRxivJuly 9, 2025Yi Zeng, Odilia Sianto, Anastasiia Lovchykova, Chang Liu, Tetsuya Akiyama, Leonard Petrucelli, Aaron D. Gitlerplates in DMEM/F12 containing ROCK inhibitor, doxycycline (Sigma Aldrich, D9891-5G), Compound E (Abcam, ab142164), laminin (Sigma Aldrich, L2020), and BrdU (Millipore Sigma, B9285). On day 4, media was changed into

(2) A high-fidelity CRISPR-Cas13 system improves abnormalities associated with C9ORF72-linked ALS/FTDNat CommunJanuary 8, 2025Tristan X. McCallister, Colin K. W. Lim, Mayuri Singh, Sijia Zhang, Najah S. Ahsan, William M. Terpstra, Alisha Y. Xiong, M. Alejandra Zeballos C, Jackson E. Powell, Jenny Drnevich, et al.per mL in Motor Neuron Maintenance Medium (AXOL Bioscience, ax0072) with 0.2 µM Compound E (Abcam, ab142164), 0.1 µM retinoic acid (Sigma-Aldrich, R2625) and 10 µM ROCK Inhibitor (Focus Biomolecules, 10-2301).

(3) Notch1 Phase Separation Coupled Percolation facilitates target gene expression and enhancer loopingScientific ReportsSeptember 19, 2024Gregory Foran, Ryan Douglas Hallam, Marvel Megaly, Anel Turgambayeva, Daniel Antfolk, Yifeng Li, Vincent C. Luca, Aleksandar Necakovimmunostaining. Drug treatments Cells treated with either CB103(Selleckchem, S9719) or compound E (ABcam, ab142164) were treated with a 1 μM final concentration for 24 h prior to fixation. If cells were to be transfected

(4) Inhibition of PHLDA3 expression in human superoxide dismutase 1-mutant amyotrophic lateral sclerosis astrocytes protects against neurotoxicityBrain CommunicationsJuly 25, 2024Kornélia Szebényi, Ingrid Vargová, Veselina Petrova, Jana Turečková, George M Gibbons, Monika Řehořová, Mai Abdelgawad, Alexandra Sándor, Dana Marekova, Jessica C F Kwok, et al.(Tocris Biosciences, 1254/10). From Day 18, N2B27 medium was supplemented with 100 nM Compound-E (Abcam, ab142164). After 72 h, the neurospheres were dissociated with papain, and the cells were plated on 96-well plates

(5) Distinct pathways drive anterior hypoblast specification in the implanting human embryoNature cell biologyMarch 1, 2024Weatherbee BAT, Weberling A, Gantner CW, Iwamoto-Stohl LK, Barnikel Z, Barrie A, Campbell A, Cunningham P, Drezet C, Efstathiou P, et al.BMP6 (SRP3017, Sigma Aldrich)85,86, 20 µM DAPT (72082, STEMCELL Technologies)87–90, 10 µM Compound-E (ab142164, Abcam)91–93, 20 µM MK-0752 (S2660, Selleck Chemicals)94–96 or dimethyl sulfoxide (DMSO) for 48 h. In

(6) Notch controls the cell cycle to define leader versus follower identities during collective cell migrationeLifeApril 19, 2022Zain Alhashem et al.at 11 hpf by adding 100 μM DAPT (Sigma-Aldrich, Cat# D5942-25MG) or 50 μM of Compound E (Abcam, Cat# ab142164). The latter reagent was used to perform live imaging, which is difficult to do with DAPT as it generates

(7) MicroRNA-582-5p Contributes to the Maintenance of Neural Stem Cells Through Inhibiting Secretory Protein FAM19A1Frontiers in cellular neuroscienceJanuary 1, 2022Zhang YF, Li XX, Cao XL, Ji CC, Gao XY, Gao D, Han H, Yu F, Zheng MH.were cultured in the proliferation medium supplemented with the gamma-secretase inhibitor (GSI, Abcam: ab142164, Cambridge, MA, United States) at the concentration of 75 μM for 6 days, with adding the same volume

(8) Establishment of an Electrophysiological Platform for Modeling ALS with Regionally-Specific Human Pluripotent Stem Cell-Derived Astrocytes and NeuronsJournal of visualized experiments : JoVEAugust 26, 2021Taga A, Habela CW, Johns A, Liu S, O'Brien M, Maragakis NJ.concentration 10 ng/mL)." CO2 tanks and regulator for Axion Edge,AirGas/Harris,9296NC, Compound E,Abcam,ab142164,Dissolve 250 μg in 2.0387 mL of DMSO to get a 250 μM stock. Aliquot and freeze at −80 °C. Dilute 1:2000

(9) A novel mechanism of gland formation in zebrafish involving transdifferentiation of renal epithelial cells and live cell extrusioneLifeNovember 5, 2018Naylor RW, Chang HG, Qubisi S, Davidson AJ.outlined in the text. Blebbistatin (SigmaAldrich #B0560), DAPT (Generon, A8200) and Compound E (Abcam, ab142164) were dissolved in DMSO to a stock concentration of 10 mM and diluted in E3 media to a working concentration

(10) BMP9 overexpressing adipose‑derived mesenchymal stem cells promote cartilage repair in osteoarthritis-affected knee joint via the Notch1/Jagged1 signaling pathwayExperimental and Therapeutic MedicineSeptember 18, 2018Xinwei Liu, Mingchang Du, Yu Wang, Songbo Liu, Xianmin Liuoverexpress BMP9), and LY411575 (LY) group (the Notch signaling pathway was inhibited by LY411575 (ab142164; Abcam, Cambridge, UK) at a final concentration of 1 nM (30), and chondrogenic induced ADMSCs overexpressed

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Compound E, gamma;-secretase inhibitor from Abcam

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Compound E, gamma;-secretase inhibitor from Abcam

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