Description
An inhibitor of MAO-B (IC50 = 4.43 nM for rat brain enzyme); selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme); inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg); reduces cerebral edema in a mouse model of traumatic brain injury; reduces cortical and hippocampal levels of full-length and soluble APP in rats and mice at 0.1 mg/kg; reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease