Digitonin from Cayman Chemical

Product Specs
ItemDigitonin
CompanyCayman Chemical
Price $330.00Supplier Page View Company Product Page
Catalog Number14952
Quantity500 mg
FormatA crystalline solid
Molecular Weight1229.3
Storage-20
FormulaC56H92O29
OriginGBR
Source/Expression SystemPlant/Digitalis purpurea
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A peptide-based screen for cell death inhibitors identifies the cytoprotective compound CDL36bioRxivJuly 10, 2026Zintis Inde, Sebastian Keppler, Jesse Gelles, Cameron S. Fraser, Adam Presser, Jarvier N. Mohammed, May Jung, David S. Garvey, Tudor Moldoveanu, Jerry E. Chipuk, et al.concentrations of 1 mM and 0.1% w/v, respectively. On the day of MST experiments, fresh digitonin (Cayman, cat #14952) was dissolved from powder and added to MST buffer to a final concentration of 0.1% w/v. Fluorescent

(2) Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor coreNature CommunicationsMarch 28, 2026Laura Y. Yen, Thomas P. Newton, Maria V. Yelshanskaya, Muhammed Aktolun, Shanti Pal Gangwar, Rasmus P. Clausen, Maria G. Kurnikova, Alexander I. Sobolevskyin the buffer containing 150 mM NaCl, 20 mM Tris-HCl pH 8.0, 1% digitonin (Cayman Chemical Company, 14952), and the same protease inhibitors as were used in the lysis buffer. The insoluble material was removed

(3) The nucleobase guanine at the 3’-terminus of oligonucleotide RGLS4326 drives off-target AMPAR inhibition and CNS toxicityNature CommunicationsNovember 28, 2025Tania Valencia, Laura Y. Yen, Cindy Berman, Thomas Vincent, Scott Davis, Francesca Varrone, Jianfeng Huang, Jessica Mastroianni, Morgan Carlson, Tate Owen, et al.solubilized for 2 h in 150 mM NaCl, 20 mM Tris-HCl pH 8.0, and 1% digitonin (Cayman Chemical Company, 14952). Insoluble material was removed by ultracentrifugation (40,000 rpm, 40 min). Cobalt-charged metal ion

(4) Activation of kainate receptor GluK2–Neto2 complexNature Structural & Molecular BiologyNovember 1, 2025Shanti Pal Gangwar, Maria V. Yelshanskaya, Laura Y. Yen, Thomas P. Newton, Alexander I. Sobolevsky2 h in a buffer containing 20 mM HEPES pH 7.5, 150 mM NaCl, 1% digitonin (Cayman Chemical Company, 14952) and the protease inhibitors mentioned above. The insoluble material was removed using ultracentrifugation

(5) Paracrine role of endothelial IGF-1 receptor in depot-specific adipose tissue adaptation in male miceNat CommunJanuary 2, 2025Cheukyau Luk, Katherine I. Bridge, Nele Warmke, Katie J. Simmons, Michael Drozd, Amy Moran, Amanda D. V. MacCannell, Chew W. Cheng, Sam Straw, Jason L. Scragg, et al.respirometry (BIOPS)74,79. Tissue was permeabilised with freshly prepared 5 μg/mL digitonin (Cayman Chemical #14952) and washed in mitochondrial respiration medium, MiR05 (MiR05: 110 mM sucrose, 60 mM K-lactobionate,

(6) Trapping of spermine, Kukoamine A, and polyamine toxin blockers in GluK2 kainate receptor channelsNature CommunicationsNovember 26, 2024Shanti Pal Gangwar, Maria V. Yelshanskaya, Muhammed Aktolun, Laura Y. Yen, Thomas P. Newton, Kristian Strømgaard, Maria G. Kurnikova, Alexander I. Sobolevsky150 mM NaCl, 20 mM Tris-HCl pH 8.0, 5 mM βME, 20 µM DNQX, and 1% digitonin (Cayman Chemical Company, 14952). Insoluble material was removed by ultracentrifugation (186,000 g, 1 h). The supernatant was added

(7) Kainate receptor channel opening and gating mechanismNatureJune 20, 2024Shanti Pal Gangwar, Maria V. Yelshanskaya, Kirill D. Nadezhdin, Laura Y. Yen, Thomas P. Newton, Muhammed Aktolun, Maria G. Kurnikova, Alexander I. SobolevskymM NaCl, 20 mM Tris-HCl pH 8.0, 1 mM β-mercaptoethanol, and 1% digitonin (Cayman Chemical Company, 14952). The insoluble material was removed by another round of ultracentrifugation (186,000g, 1 h). The supernatant

(8) A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRASCell Stem CellJanuary 1, 2024Xiaohua Duan, Tuo Zhang, Lingling Feng, Neranjan de Silva, Benjamin Greenspun, Xing Wang, Jenna Moyer, M. Laura Martin, Rohit Chandwani, Olivier Elemento, et al.# 1258-84-0 Gambogic acid,MedchemExpress,Catalog: # HY-N0087 Digitonin,Cayman Chemical,Catalog: # 14952 Celastrol,Cayman Chemical,Catalog: # 34157-83-0 Lestaurtinib,Cayman Chemical,Catalog: # 111358-88-4 Betulin,MedchemExpress,Catalog:

(9) Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanelCell ReportsFebruary 21, 2023Shanti Pal Gangwar, Laura Y. Yen, Maria V. Yelshanskaya, Alexander I. SobolevskyTechnologies,Cat# HCT-0020 Desthiobiotin,Sigma,Cat# D1411 Digitonin,Cayman Chemical Company,Cat# 14952 Perampanel,Cayman,Cat# 23003 BPAM344,AOBIOUS,Cat# AOB12707 DNQX dosodium salt,Tocris,Cat# 2312 Fetal

(10) Opening of glutamate receptor channel to subconductance levelsNatureMay 5, 2022Maria V. Yelshanskaya, Dhilon S. Patel, Christopher M. Kottke, Maria G. Kurnikova, Alexander I. Sobolevskythat contained 150 mM NaCl, 20 mM Tris-HCl pH 8.0, 1 mM βME and 1% digitonin (Cayman Chemical Company, 14952). Insoluble material was removed by ultracentrifugation (186,000g, 40 min). The supernatant was added

(11) Purification and cryo-EM structure determination of Arabidopsis thaliana GLR3.4STAR ProtocolsDecember 17, 2021Shanti Pal Gangwar, Marriah N. Green, Maria V. Yelshanskaya, Alexander I. SobolevskyFreestyle 293 expression medium,Gibco,Cat# 12338018 Sodium butyrate,Acros Organics,Cat# 263191000 Digitonin,Cayman Chemical Company,Cat#14952 Aprotinin,Sigma-Aldrich,Cat#A1153 Leupeptin,Sigma-Aldrich,Cat#L0649 Pepstatin A,Sigma-Aldrich,Cat#P4265 Kanamycin,Fisher Scientific

(12) Structure and desensitization of AMPA receptor complexes with type II TARP γ5 and GSG1LMolecular CellDecember 1, 2021Oleg Klykov, Shanti Pal Gangwar, Maria V. Yelshanskaya, Laura Yen, Alexander I. Sobolevskycontaining 150 mM NaCl, 20 mM Tris-HCl pH 8.0, 0.005% CHS and 0.05% digitonin (Cayman Chemical Company, 14952), and the protein was eluted using the same buffer supplemented with 2.5 mM D-desthiobiotin. To remove

(13) Structure of the Arabidopsis thaliana glutamate receptor-like channel GLR3.4Molecular CellAugust 1, 2021Marriah N. Green et al.containing 150 mM NaCl, 20 mM Tris-HCl pH 8.0, 1 mM βME and 1% digitonin (Cayman Chemical Company, 14952). Insoluble material was removed by ultracentrifugation (186,000 g, 40 min), while the supernatant was

(14) TRPV3 expression and purification for structure determination by Cryo-EMMethods in EnzymologyJune 1, 2021Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. SobolevskyPepstatin A,Sigma,P4265 Strep-Tactin® Sepharose® (strep resin),iBa,2-1201-025 Digitonin,Cayman Chemical Company,14952 GDN101,Anatrace,1402423-29-3 Soybean Polar Lipid Extract,Avanti Polar Lipids,541602 Bio-Beads SM-2,Bio-Rad,152–8920 Critical

(15) Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2ElifeJuly 15, 2020Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow Long-D-glucopyranosyl-(1→3)-O-β-D-galactopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→4)-β-D-galactopyranoside",Cayman Chemical Company,14952, "Chemical compound, drug",Membrane Scaffold Protein 1D1,Sigma,M6574, "Chemical compound, drug",5-Methyl-2-oxo-4-imidazo

(16) Structures reveal gatekeeping of the mitochondrial Ca2+ uniporter by MICU1-MICU2eLifeJuly 15, 2020Chongyuan Wang, Agata Jacewicz, Bryce D Delgado, Rozbeh Baradaran, Stephen Barstow LongO-b -D-glucopyranosyl-(1!3)-O-b-Dgalactopyranosyl-(1!2)-O[b-D-xylopyranosyl-(1!4)-bD-galactopyranoside Cayman Chemical Company 14952 Chemical compound, drug Membrane Scaffold Protein 1D1 Sigma M6574 Chemical compound, drug 5-Methyl-2-oxo-4-imidazo lidinehexanoic

(17) Allosteric AKT Inhibitors Target Synthetic Lethal Vulnerabilities in E-Cadherin-Deficient CellsCancers (Basel)September 13, 2019Nicola Bougen-Zhukov et al.USA). ARQ-092 (#21388), perifosine (#1008112), PHT-427 (#24188), staurosporine (#81590), digitonin (#14952), and FCCP (#15218) were purchased from Cayman Chemical. Oligomycin (#O4876), β-mercaptoethanol (#M3148),

(18) Mechanisms of Channel Block in Calcium-Permeable AMPA ReceptorsNeuronSeptember 1, 2018Edward C. Twomey, Maria V. Yelshanskaya, Alexander A. Vassilevski, Alexander I. Sobolevskysolubilized for two hours in 150 mM NaCI, 20 mM Tris-HCl pH 8.0, 1% digitonin (Cayman Chemical Company #14952). Insoluble material was removed by ultracentrifugation (40,000 rpm, 40 minutes). TALON cobalt-charged

(19) Tissue Damage Signaling Is a Prerequisite for Protective Neutrophil Recruitment to Microbial Infection in ZebrafishImmunityMay 15, 2018Cong Huang, Philipp NiethammerAcetylsalicylic acid (Aspirin),ACROS Organics,Cat#AC158180025 Cycloheximide,Sigma,Cat#01810 Digitonin,Cayman,Cat#14952 Dimethyl sulfoxide,Sigma,Cat#276855 ethyl 3-aminobenzoate methanesulfonate,Sigma,Cat#10521 Gentamycin,IBI

(20) Channel opening and gating mechanism in AMPA-subtype glutamate receptorsNatureSeptember 7, 2017Edward C. Twomey, Maria V. Yelshanskaya, Robert A. Grassucci, Joachim Frank, Alexander I. Sobolevskysolubilized for two hours in 150 mM NaCl, 20 mM Tris-HCl pH 8.0, 1% digitonin (Cayman Chemical Company #14952). Insoluble material was removed by ultracentrifugation (40,000 rpm, 40 minutes). Streptavidin-linked

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Digitonin from Cayman Chemical

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Cayman Chemical

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Digitonin from Cayman Chemical

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