Description
An inhibitor of SARS-CoV Mpro (Ki = 306 nM); selective for SARS-CoV Mpro over calpain, trypsin, and thrombin (Kis = 10, >100, and >100 µM, respectively); inhibits the protein-protein interaction between p53 and MDM2 in U2OS osteosarcoma cells at 20 µM; has been used as a building block in the synthesis of HIV protease inhibitors