ALK5 Inhibitor II from Cayman Chemical

Product Specs
ItemALK5 Inhibitor II
CompanyCayman Chemical
Price $319.00Supplier Page View Company Product Page
Catalog Number14794
Quantity25 mg
Research AreaCell Biology, Cell Signaling, Reprogramming, Stem Cell Research
FormatA crystalline solid
Molecular Weight287.3
Purity≥98%
Storage-20
FormulaC17H13N5
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A stem cell knockout village reveals lineage rewiring and a non-canonical islet cell fate in monogenic diabetesbioRxivJanuary 2, 2026Dingyu Liu, Bicna Song, Zhaoheng Li, Stephen Zhang, Tabassum Fabiha, Jiahui Zhao, Ayaka Inoki, Julie Piccand, Chew-Li Soh, Gary Dixon, et al.Millipore, 565740). Day 11–17: S5 medium supplemented with 10 μM ALK5i II (Cayman Chemical Company, 14794–5), 0.1 μM retinoic acid, 0.25 μM SANT-1, 0.25 mM VitC, 1 μM T3 (Sigma-Aldrich, T6397), 10 mg/ml Heparin

(2) Enhanced Schwann cell differentiation of skin‐derived neural crest‐like stem cells through the synergistic action of SOX10 and immobilized NRG1 signalingBioengineering & Translational MedicineNovember 1, 2025Ashis Kumar Podder, Pihu Mehrotra, Pedro Lei, Stelios T. Andreadisinvestigation of the effect of small reprogramming molecules (Forskolin, Fsk: 10 μM, Cayman Chemical, Catalog #14794; Valproic acid, VPA: 500 μM, Cayman Chemical, Catalog #13033; RepSox, Rep: 10 μM, Cayman Chemical, Catalog

(3) Engineered vasculature induces functional maturation of pluripotent stem cell-derived islet organoidsDevelopmental CellSeptember 22, 2025Yesl Jun, Kim-Vy Nguyen-Ngoc, Somesh Sai, R. Hugh F. Bender, Winnie Gong, Vira Kravets, Han Zhu, Christopher J. Hatch, Michael Schlichting, Roberto Gaetani, et al.Systems,Cat# 338-AC/CF ALK5 inhibitor II (ALK5i II),Enzo Life Sciences Cayman Chemicals,Cat# ALX-270-445 Cat# 14794 L-Ascorbic Acid (Vitamin C),Sigma-Aldrich,Cat# A4544 BSA,Proliant,Cat# 68700 CHIR99021,SelleckChem,Cat#

(4) Integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D-associated genes and regulatory signalsCell reportsAugust 26, 2025D'Oliveira Albanus R, Zhang X, Zhao Z, Taylor HJ, Tang X, Han Y, Orchard P, Varshney A, Zhang T, Manickam N, et al.salt,Sigma-Aldrich,Cat#H3149–1MU γ-Secretase Inhibitor XX,Millipore,Cat#565789–1MG ALK5 Inhibitor II,Cayman Chemical,Cat#14794 L-Ascorbic acid,Sigma-Aldrich,Cat#A4544–100G N-acetyl-L-cysteine,Sigma-Aldrich,Cat#A9165–5G Human

(5) Chemical reprogramming ameliorates cellular hallmarks of aging and extends lifespanEMBO Molecular MedicineJune 30, 2025Lucas Schoenfeldt, Patrick T Paine, Sara Picó, Nibrasul H Kamaludeen M, Grace B Phelps, Calida Mrabti, Gabriela Desdín-Micó, María del Carmen Maza, Kevin Perez, Alejandro OcampoThermo Fisher: DHE (D11347), Paraquat (856177); Cayman: Valproic Acid (13033), CHIR99021 (13122), Repsox (14794), Forskolin (11018), Doxorubicin (15007); Acros Organics: TCP (130472500); APExBIO: DZNep (A8182), Metformin

(6) The Multi-Kinase Inhibitor RepSox Enforces Barrier Function in the Face of Both VEGF and CytokinesBiomedicinesAugust 31, 2023Lietuvninkas L, Baccouche B, Kazlauskas A.ThermoFisher Scientific (Waltham, MA, USA). RS was purchased from both Selleckchem (S7223) and Cayman (14794). Recombinant human VEGF 165 (100-20), recombinant human TNFα (300-01A), recombinant human IL-1β (200-01B),

(7) Protocol development to further differentiate and transition stem cell-derived pancreatic progenitors from a monolayer into endocrine cells in suspension cultureScientific ReportsJune 1, 2023Mitchell J. S. Braam, Jia Zhao, Shenghui Liang, Shogo Ida, Nick K. Kloostra, Diepiriye G. Iworima, Mei Tang, Robert K. Baker, Nina Quiskamp, James M. Piret, et al.(STEMCELL, Cat#72147), 1 μM T3 (Millipore Sigma, Cat#T6397), 10 μM ALK5i II (Cayman Chemical Company, Cat#14794), 10 μM zinc sulfate (Sigma-Aldrich, Cat#Z0251), and 10 μg/mL heparin (Fisher Scientific, Cat#AC411210010)

(8) Differentiation of stem cell-derived pancreatic progenitors into insulin-secreting islet clusters in a multiwell-based static 3D culture systemCell Rep MethodsMay 22, 2023Liang S, Zhao J, Baker RK, Tran E, Zhan L, Kieffer TJ.72147 TPPB,Tocris,Cat# 5343/1 Triiodothyronine (T3),Sigma-Aldrich,Cat# T6397 ALK5 inhibitor II,Cayman Chemicals,Cat# 14794 Zinc sulfate,Sigma-Aldrich,Cat# Z0251 Heparin,Sigma-Aldrich,Cat# H3149 Gamma secretase inhibitor

(9) Engineered whole cut meat-like tissue by the assembly of cell fibers using tendon-gel integrated bioprintingNature communicationsAugust 24, 2021Kang DH, Louis F, Liu H, Shimoda H, Nishiyama Y, Nozawa H, Kakitani M, Takagi D, Kasa D, Nagamori E, et al.2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, at 1–10 µM final concentration, Cayman, 14794), or Bovine Endothelial Cell Growth Medium (Cell Applications Inc., B211K-500). The individual seven

(10) Injectable Drug‐Releasing Microporous Annealed Particle Scaffolds for Treating Myocardial InfarctionAdvanced Functional MaterialsOctober 22, 2020Jun Fang et al.solution for NPs fabrication. In addition, forskolin (cat# 11018, Cayman Chemical) and Repsox (cat# 14794, Cayman Chemical) were selected and loaded into NPs to generate FR/NPs. The aforementioned protocol

(11) Endothelial TGF-β signaling instructs smooth muscle cell development in the cardiac outflow tracteLifeSeptember 29, 2020Giulia LM Boezio, Anabela Bensimon-Brito, Janett Piesker, Stefan Guenther, Christian SM Helker, Didier YR StainierSYBR Green qPCR Mix,Thermo Scientific,Cat# F416S, "Chemical compound, drug",E-616452,Cayman Chemical,14794, "Chemical compound, drug",SIS3,Calbiochem/Merck,566405, "Chemical compound, drug",EdU,Thermo Fisher Scientific

(12) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and OrganoidsCell stem cellJuly 2, 2020Yang L, Han Y, Nilsson-Payant BE, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, et al.,Sigma Aldrich,#H3149-1MU γ-Secretase Inhibitor XX,Millipore,#565789-1MG ALK5 Inhibitor II,Cayman Chemical,#14794 L-Ascorbic acid,Sigma Aldrich,#A4544-100G R428,MedchemExpress,#HY-15150 N-acetyl-L-cysteine,Sigma Aldrich

(13) Sel1L-Hrd1 ER-associated degradation maintains β cell identity via TGF-β signalingThe Journal of clinical investigationJuly 1, 2020Shrestha N, Liu T, Ji Y, Reinert RB, Torres M, Li X, Zhang M, Tang CA, Hu CA, Liu C, et al.TGF-βRI inhibitor, islets from 5- to 6-week-old mice were cultured with Alk5 inhibitor II (10 μM; Cayman, 14794) or vehicle (DMSO) for 24 hours. Flow cytometry. Mouse islets were isolated and cultured with RPMI 1640

(14) Using a barcoded AAV capsid library to select for clinically relevant gene therapy vectorsJCI insightNovember 14, 2019Pekrun K, De Alencastro G, Luo QJ, Liu J, Kim Y, Nygaard S, Galivo F, Zhang F, Song R, Tiffany MR, et al.(Thermo Fisher Scientific, 35050-061), 1:100 NEAA (Thermo Fisher Scientific, 11140-050), 10 μm ALKi II (Cayman Chemical, 14794), 0.5 mM vitamin C (MilliporeSigma, 49752-10G), 1 μM T3 (MilliporeSigma, T6397), 1 mM N-acetyl Cysteine

(15) Rapid generation of functional mature pancreatic islet-beta cells from human pluripotent stem cellsProtocol ExchangeFebruary 4, 2019Gopika Nair, Gopika Nair, Holger Russ, Matthias Hebrok\(Life Tech #11960-051) B27- 1:100 \(Gibco) NEAA- 1:100 \(Gibco) ALKi II- 10 μm \(Cayman Chemical #14794) LDN‐193189 - 500 Page 2/7 nM \(Fisher #04-0074-10) Xxi - 1 μm \(Millipore #565789) T3- 1 μM \(Sigma-Aldrich

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ALK5 Inhibitor II from Cayman Chemical

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Cayman Chemical

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ALK5 Inhibitor II from Cayman Chemical

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