Description
An aromatase inhibitor (IC50 = 2 nM); inhibits proliferation of ER+ MCF-7 cells at 0.1-100 nM; inhibits proliferation of MCF-7 cells when used at 10 nM in combination with testosterone or 4-androstene-3,17-dione; reduces MMP-2 and MMP-9 levels in MCF-7 cells at 10 nM; reduces tumor growth in an MCF-7Ca ovariectomized-mouse xenograft model at 10 µg per day