DMXAA from Cayman Chemical

Product Specs
ItemDMXAA
CompanyCayman Chemical
Price $290.00Supplier Page View Company Product Page
Catalog Number14617
Quantity25 mg
Research AreaAngiogenesis, Apoptosis, Autoimmunity, Cancer, Cell Death, Cell Signaling, Growth Factor Receptor Signaling, Immunology & Inflammation, Infectious Disease, Innate Immunity, Pattern Recognition, STING
FormatA crystalline solid
Molecular Weight282.3
Purity≥98%
Storage-20
FormulaC17H14O4
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A PI(3,5)P2/CHMP4B axis on lysosomes is essential for microautophagic degradation of STINGNat CommunMay 27, 2026Tsumugi Shoji, Ayumi Shinojima, Takuma Kishimoto, Kanako Sato, Nana Ikegami, Eisuke Yumoto, Ruri Shindo, Yasunori Uchida, Satoshi Kusumi, Daisuke Koga, et al.Supplementary Data 2. The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman), bafilomycin A1 (11038, Cayman), brefeldin A (11861, Cayman), Custom Kinase Screening Library

(2) Microbiota-derived secondary bile acids promote STING activation and antitumor activitybioRxivApril 12, 2026Xinglin Yang, Xing Zhang, Weichao Li, Anant Gharpure, Althea Hansel-Harris, Andreas F. Tillack, Chongyang Wu, Yan-Zhu Hsieh, Ariana Sulpizio, Kyong T. Fam, et al.37354), cholic acid (97%, Alfa Aesar, A11267), NVS-STG2 (98%, MCE, HY-157214), DMXAA (≥98%, Cayman, 14617), BB-Cl-Amidine (≥95%, MCE, hy-111347), single-stranded template DNA (HT-DNA) (sigma, D7656), deoxycholic

(3) SP140–RESIST pathway regulates interferon mRNA stability and antiviral immunityNatureJuly 31, 2025Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia Vosshall Lee, David J. Turner, Azra Lari, Moritz M. Gaidt, et al.(Invivogen, tlrl-3pelps), 100 μg ml−1 poly(I:C) (Invivogen, tlrl-picw), 100 μg ml−1 DMXAA (Cayman Chemicals, 14617) or 10 ng ml−1 IFNγ (BioLegend, 575304). RT–qPCR RNA was isolated using the Omega Biotek Total RNA

(4) A quantitative method to monitor STING degradation with dual-luciferase reportersCell Structure and FunctionMay 20, 2025Tsumugi Shoji, Kanako Sato, Ayumi Shinojima, Shogo Koide, Ruri Shindo, Kazune Hongo, Kojiro Mukai, Yoshihiko Kuchitsu, Tomohiko TaguchiPromega). Reagents The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman), MLN7243 (30108, Cayman), and HT-DNA (D6898, Sigma). The plasmids encoding NLuc and FLuc were

(5) The SP140-RESIST pathway regulates interferon mRNA stability and antiviral immunitybioRxivJanuary 30, 2025Kristen C. Witt, Adam Dziulko, Joohyun An, Filip Pekovic, Arthur Xiuyuan Cheng, Grace Y. Liu, Ophelia Vosshall Lee, David J. Turner, Azra C Lari, Moritz M. Gaidt, et al.(Invivogen, tlrl-3pelps), 100 μg/mL poly(I:C) (Invivogen, tlrl-picw), or 100 μg/mL DMXAA (Cayman Chemicals, 14617). RT-qPCR RNA was isolated with the Omega Biotek Total RNA II kit according to kit instructions. RNA

(6) AIM2 promotes excitatory glutamate receptor expression by inhibiting STING and contributes to bone cancer pain in male miceScientific ReportsDecember 30, 2024Linhan Wang, Xueqin Xu, Shanchun Su, Biyun Li, Kunyu Zhang, Xiuqin Yu, Yangqiao Xiao, Shuangshuang Lu, Zihao Lu, Yanqiong Wu, et al.Committee. Drug treatment The compound 5,6-dimethyl-9-oxo-9H-xanthene-4-acetic acid (DMXAA) (cat. no.:14617; Cayman Chemical, USA) was diluted in a sterilized PBS solution containing 5% DMSO to achieve a concentration

(7) A TBK1-independent primordial function of STING in lysosomal biogenesisMolecular CellOctober 17, 2024Bo Lv, William A. Dion, Haoxiang Yang, Jinrui Xun, Do-Hyung Kim, Bokai Zhu, Jay Xiaojun Tan(Cayman Chemical, #29958, 20 μM), bafilomycin A1 (Cayman Chemical, #11038, 25-200 nM), DMXAA (Cayman Chemical, #14617, 70 μM), Torin 1 (Cayman Chemical, #10997, 1 μM). HT-DNA (1 μg/ml) was transfected into BJ cells by

(8) Microglial STING activation alleviates nerve injury-induced neuropathic pain in male but not female miceBrain, behavior, and immunityMarch 1, 2024Silveira Prudente A, Hoon Lee S, Roh J, Luckemeyer DD, Cohen CF, Pertin M, Park CK, Suter MR, Decosterd I, Zhang JM, et al.were used in this study: ADU-S100 (Chemietek, Cat. No: CT-ADUS100), DMXAA (Cayman Chemical, Cat. No: 14617), GSK8612 (Selleckchem, Cat. No: S8872), anti-rat IFN-ß neutralizing antibody (PBL Assay Science, Cat.

(9) Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterolNature CommunicationsJanuary 11, 2024Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, et al.(Thermo Fisher Scientific). Reagents The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman); di-4-ANEPPDHQ (D36802, Thermo Fisher Scientific); HaloTag® SaraFluorTM 650 T Ligand (A308-02,

(10) AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanismsCell Chemical BiologyDecember 1, 2023Johnny Castillo Castillo Cabrera, Hong Dang, Adam Graves, Zhigang Zhang, Jose Torres-Castillo, Kelin Li, Zayna King, Pengda Liu, Jeff Aubé, James E. Bear, et al.24 hours prior to experiments. METHOD DETAILS Cell treatments RAW264.7 DMXAA (Cayman Chemical, 14617) treatments were carried out at a 10 μg/mL dose for all experiments at a density of 3.5x106 cells in

(11) C9ORF72 suppresses JAK-STAT mediated inflammationiScienceMay 19, 2023Pang W, Hu F.G-6185 ruxolitinib,Cayman Chemical,Cat# 11609 LLOME,Cayman Chemical,Cat# 16008 DMXAA,Cayman Chemical,Cat# 14617 IFNα,BioLegend,Cat# 752802 Poly (I:C),Invivogen,Cat# tlrl-pic LPS,Sigma-Aldrich,Cat# L2630 Imiquimod,Cayman Chemical

(12) STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomesNature Cell BiologyMarch 13, 2023Yoshihiko Kuchitsu, Kojiro Mukai, Rei Uematsu, Yuki Takaada, Ayumi Shinojima, Ruri Shindo, Tsumugi Shoji, Shiori Hamano, Emari Ogawa, Ryota Sato, et al.Supplementary Table 2. The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman), anti-FLAG M2 Affinity Gel (A2220, Sigma), LysoTracker Deep Red (L12492, Thermo Fisher Scientific),

(13) A non-nucleotide agonist that binds covalently to cysteine residues of STINGCell Structure and FunctionFebruary 16, 2023Kentaro Matsumoto, Shenwei Ni, Hiroyuki Arai, Takashi Toyama, Yoshiro Saito, Takehiro Suzuki, Naoshi Dohmae, Kojiro Mukai, Tomohiko Taguchi(BD Biosciences). Reagents The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman); nocodazole (13857, Cayman); 2-bromopalmitate (320-76562, Wako); 2',3'-cGAMP (InvivoGen); D-ceramide-C6

(14) Specific association of TBK1 with the trans-Golgi network following STING stimulationCell Structure and FunctionMarch 8, 2022Haruka Kemmoku, Yoshihiko Kuchitsu, Kojiro Mukai, Tomohiko Taguchiin E. coli. Reagents The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman); Nocodazole (13857, Cayman); Brefeldin A (11861, Cayman); MRT67307 (19916, Cayman). PCR cloning N-terminal

(15) STING suppresses bone cancer pain via immune and neuronal modulationNature communicationsJuly 27, 2021Wang K, Donnelly CR, Jiang C, Liao Y, Luo X, Tao X, Bang S, McGinnis A, Lee M, Hilton MJ, et al.survival. Methods Reagents The following reagents were used in this study: DMXAA (Cayman Chemical, 14617), ADU-S100 (Chemietek, CT-ADUS100), 3’3’-cGAMP (Invivogen, tlr-nacga), poly(dA:dT)/LyoVec (Invivogen,

(16) A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylationScientific reportsJune 7, 2021Takahashi K, Niki T, Ogawa E, Fumika K, Nishioka Y, Sawa M, Arai H, Mukai K, Taguchi T.| https://doi.org/10.1038/s41598-021-91562-z 6 www.nature.com/scientificreports/ Reagents. The following reagents were purchased from the manufacturers as noted: DMXAA (14617, Cayman), brefeldin A (11861, Cayman), methyl-β-cyclodextrin (332615, Sigma), recombinant bacterial

(17) STING controls nociception via type I interferon signalling in sensory neuronsNatureMarch 11, 2021Christopher R. Donnelly et al.following reagents and concentrations: DMXAA (various concentrations, as indicated; Cayman Chemical, 14617), ADU-S100 (various concentrations, as indicated; Chemietek, CT-ADUS100), 2’3’-cGAMP (10 μg, i.t.; Invivogen,

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DMXAA from Cayman Chemical

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Cayman Chemical

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DMXAA from Cayman Chemical

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