Cycloheximide from Cayman Chemical

Product Specs
ItemCycloheximide
CompanyCayman Chemical
Price $66.00Supplier Page View Company Product Page
Catalog Number14126
Quantity1 g
Research AreaApoptosis, Cell Biology, Cell Death, Epigenetics, Transcription, & Translation, Immunology & Inflammation, Innate Immunity, RNA, DNA, & Protein Synthesis
FormatA crystalline solid
Molecular Weight281.4
Purity≥95%
Storage-20
FormulaC15H23NO4
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Deubiquitination of ETV4 by USP7 Promotes NSCLC Tumorigenesis via MAPK7 ActivationHum MutatMay 6, 2026Xue Meng, Jiaxi Zhang, Ning Zhang, Yuqi Hou, Yimeng Li, Jia Kang, Ruxin Li, Yinghui Shi, Juan Wang, Lixin Cheng, et al.incubated at 37°C under 5% CO2. USP7 inhibitor P22077 (23704), MG132 (10012628), and cycloheximide (CHX) (14126) were purchased from Cayman Chemical. 2.3. siRNA Transfection, Plasmid Construction and Transfection,

(2) OGT mediates O-GlcNAcylation of MEIS2 and affects palatal osteogenic developmentInt J Oral SciApril 6, 2026Zhongyin Zhang, Zerui Shan, Xinyu Chen, Yu Xia, Li Meng, Yuxin Zhang, Caihong Wu, Lichan Yuan, Junqing MaMEIS2 protein was detected by treating HEPM cells with 250 μmol/L cycloheximide (CHX) (Cayman Chemical,14126) and collecting them at 0, 1, 2 and 3 h. To detect the protein stability of exogenous Flag-MEIS2, HEK293 cells

(3) Acetylation-triggered degradation of MSX1 impairs palatal developmentCell Death DiscoveryMarch 19, 2026Li Meng, Jiawen You, Zhongyin Zhang, Yucheng Jiang, Yulan Liu, Mingliang Zhou, Junqing Ma, Xinquan JiangnM, 6 h), EX527 (MCE, HY-15452) (10 µM, 24 h), MG132 (MCE, HY-13259) (10 µM, 4 h) and CHX (Cayman, 14126) (50 mM, 0–12 h). Plasmids A GFP-tagged MSX1 expression plasmid was generated by subcloning full-length

(4) Regulation of MRGPRX2-mediated mast cell function by competence-stimulating peptide 1 and pro-adrenomedullin peptideFrontiers in ImmunologyMarch 17, 2026Aetas Amponnawarat, Sangita Sutradhar, Chalatip Chompunud Na Ayudhya, Maram Bawazir, Ronit Sagi-Eisenberg, Hydar Ali(Catalog #E2620). Dyngo-4a and Cycloheximide were obtained from Cayman Chemical (Catalog #29479 and #14126). Phycoerythrin (PE)-conjugated mouse anti-MRGPRX2 antibody (Clone K125H4; Catalog #259004), unconjugated

(5) Regulation of MRGPRX2-mediated mast cell function by competence-stimulating peptide 1 and pro-adrenomedullin peptideFront ImmunolMarch 17, 2026Aetas Amponnawarat, Sangita Sutradhar, Chalatip Chompunud Na Ayudhya, Maram Bawazir, Ronit Sagi-Eisenberg, Hydar Ali(Catalog #E2620). Dyngo-4a and Cycloheximide were obtained from Cayman Chemical (Catalog #29479 and #14126). Phycoerythrin (PE)-conjugated mouse anti-MRGPRX2 antibody (Clone K125H4; Catalog #259004), unconjugated

(6) Systematic Evaluation Defines the Limits of Ferroptosis in Cancer TherapybioRxivMarch 17, 2026Kenji M. Fujihara, Azmi Aziz, Behnia Akbari, Maria Gutierrez-Perez, Gregory Francis, Siham Zentout, Kameng Wu, Nicholas J. Clemons, Erdem M. Terzi, Michael E. Pacold, et al.beta-mercaptoethanol (NC9604560, Fisher Scientific), ferrostatin-1 (SML0583, Sigma), cycloheximide (14126, Cayman), eprenetapopt (gift from Aprea Therapeutics), DMSO (3176, Cell Signaling Technologies), sodium

(7) Ubiquitin ligase Nedd4 regulates the abundance and toxicity of mutant huntingtinJCI InsightFebruary 23, 2026Hyunkyung Jeong, Yiyang Qin, Fangke Xu, Katarina Trajkovic, Myung Jong Kim, Nicolas Marotta, Kana Hamada, Ravi Allada, Su Yang, Dimitri KraincZeptoMetrix RETROtek HIV-1 p24 Antigen ELISA (22-156-700, Fisher), FBS (100-106, Gemini Bio), CHX (14126, Cayman Chemical), bafilomycin A1 (11038, Cayman Chemical), bortezomib (#2204, Cell Signaling Technology),

(8) Studying Cargo Transport Using RudLOVBIO-PROTOCOLOctober 20, 2025Tatsuya Tago, Takunori Satoh, Akiko K. SatohNocodazole (Cayman Chemicals, catalog number: 13857) 9. Cycloheximide (Cayman Chemicals, catalog number: 14126) 10. Biotin (FUJIFILM Wako Chemicals, catalog number: 029-08713) 11. Biliverdine (TRC, catalog number:

(9) Studying Cargo Transport Using RudLOVBio ProtocOctober 20, 2025Tatsuya Tago, Takunori Satoh, Akiko K. SatohNocodazole (Cayman Chemicals, catalog number: 13857) 9. Cycloheximide (Cayman Chemicals, catalog number: 14126) 10. Biotin (FUJIFILM Wako Chemicals, catalog number: 029-08713) 11. Biliverdine (TRC, catalog number:

(10) A distinct neural ensemble to integrate contradictory information and form long-term memory in DrosophilaSci AdvAugust 15, 2025Habib Ullah, Yu-Luen Hwang, Ming-Chi Hsu, Hsueh-Cheng Chiangsucrose (99.5%) (57501) are from Sigma-Aldrich. Isopentyl acetate (99%) (B21618) is from Alfa Aesar. CHX (14126) is from Cayman. W1118, UAS-Shibirets is from Y. Zhong. UAS-TrpA1 (26263), UAS-ricincs (38623), R16A06-GAL4

(11) Disturbed engram network caused by NPTX downregulation underlies aging-related contextual fear memory deficitsCell ResearchAugust 1, 2025Tao Jin, Yang Yang, Yu Guo, Yi Zhang, Qiumin Le, Nan Huang, Xing Liu, Jintai Yu, Lan Ma, Feifei Wangsupplemented hybridization buffer (HB-S) containing dithiothreitol (Sigma, D9760), cycloheximide (Cayman, 14126), heparin (Tocris, 2812), protease inhibitors (Roche, 04693116001), and RNase inhibitor (Vazyme, R301).

(12) Aging-Associated Vacuolation of Multi-Ciliated Cells in the Distal Mouse Oviduct Reflects Unique Cell Identity and Luminal MicroenvironmentAging cellJuly 1, 2025Harwalkar K, Yamanaka N, Pacis AS, Zhao S, Teng K, Pitman W, Taskar M, Lynn V, Thornton AF, Ford MJ, et al.mM hydroxyurea (HU, Sigma Aldrich, H8627‐5G), 10 μg/mL cycloheximide (CHX, Cayman Chemical Company, 14126), 2 μM 6‐Aminonicotinamide (6‐AN, Sigma, A68203‐1G), 1 μM YZ‐9 (Cayman Chemical Company, 15352), 5 μM

(13) Tobacco Smoking Rewires Cell Metabolism by Inducing GAPDH Succinylation to Promote Lung Cancer ProgressionCancer ResMay 14, 2025Kun Wang, Jingzhuo Li, Hai Zhang, Hongyan Ma, Hong-Yong Cui, Huai-Qiang Ju, Jing Zhang, Qing-zhi Ma, Ming Zhao, Qing-mei Zeng, et al.University. Chemicals A485 (cat. #HY-107455) was acquired from MedChemExpress. MG132 (cat. #13697) and cycloheximide (cat. #14126) were acquired from Cayman Chemical. Deacetylase inhibitor mixture (cat. #P1113) and RIPA lysis buffer

(14) Palmitoylation prevents B7-H4 lysosomal degradation sustaining tumor immune evasionNat CommunMay 8, 2025Yijian Yan, Jiali Yu, Weichao Wang, Ying Xu, Kole Tison, Rongxin Xiao, Sara Grove, Shuang Wei, Linda Vatan, Max Wicha, et al.Curcumin (#81025), Anacardic acid (#18422), Lonfarnib (#11746), Cerulenin (#10005647), Cycloheximide (#14126), E-64d (#13533), Pepstatin A (#9000469), Bafilomycin A1 (#11037), Palbociclib (PD0332991), Ribociclib(#17666),

(15) BRD4 regulates m6A of ESPL1 mRNA via interaction with ALKBH5 to modulate breast cancer progressionActa Pharmaceutica Sinica BMarch 1, 2025Haisheng Zhang, Linlin Lu, Cheng Yi, Tao Jiang, Yunqing Lu, Xianyuan Yang, Ke Zhong, Jiawang Zhou, Jiexin Li, Guoyou Xie, et al.Protein stability To measure protein stability, cells were treated with cycloheximide (CHX, Item NO 14126, Cayman Chemical, USA) at final concentration 20 μg/mL for indicated times. The expression of protein

(16) eEF2K regulates pain through translational control of BDNFMolecular CellFebruary 20, 2025Patrick R. Smith, Guadalupe Garcia, Angela R. Meyer, Alexey G. Ryazanov, Tao Ma, Sarah Loerch, Zachary T. Campbell,Cayman Chemical,CAS No. 22862-766; Cat No. 11308 Cycloheximide (CHX),Cayman Chemical,CAS No. 66-81-9; Cat. No. 14126 GCN2-IN-7 (IN-7),MedChemExpress,CAS No. 239646533-9; Cat No. HY-151460 2BAct,MedChemExpress,CAS No.

(17) Targeting PPARγ via SIAH1/2-mediated ubiquitin-proteasomal degradation as a new therapeutic approach in luminal-type bladder cancerCell Death & DiseaseDecember 18, 2024Chih-Chieh Tu, Tsung-Han Hsieh, Cheng-Ying Chu, Yu-Chen Lin, Bo-Jyun Lin, Chun-Han Chenwere purchased from MedChem Express (Monmouth Junction, NJ, USA). Cisplatin (13119) and cycloheximide (14126) were purchased from Cayman Chemicals (Ann Arbor, MI, USA). Other chemicals used in this study were

(18) RudLOV is an optically synchronized cargo transport method revealing unexpected effects of dynasoreEMBO ReportsDecember 10, 2024Tatsuya Tago, Takumi Ogawa, Yumi Goto, Kiminori Toyooka, Takuro Tojima, Akihiko Nakano, Takunori Satoh, Akiko K SatohSerum,Nichirei,174012 Dynasore,Cayman Chemicals,14062 Nocodazole,Cayman Chemicals,13857 Cycloheximide,Cayman Chemicals,14126 Dynole 34-2,Abcam,120464 Dynole 31-2,Abcam,120474 Dyngo-4a,Cayman Chemicals,29479 Biotin,FUJIFILM

(19) Dose-dependent responses to canonical Wnt transcriptional complexes in the regulation of mammalian nephron progenitorsDevelopment (Cambridge, England)September 15, 2024Bugacov H, Der B, Briantseva BM, Guo Q, Kim S, Lindström NO, McMahon AP.transfection, NPCs were cultured in 0 μM CHIR NPEM for 24 h. Cycloheximide experiments Cycloheximide (CHX) (14126, Cayman Chemical) was resuspended in DMSO and stored as 25 mg/ml stock solution at −20°C. To achieve

(20) The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancerJournal of Experimental & Clinical Cancer ResearchJune 20, 2024Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang, Qunye He, Shuyi Xu, Junyan Li, Yunji Liao, Yu Chen, Shusheng Wang, et al.MCE, USA) or tamoxifen was added to the cells 1 h before cycloheximide treatment. Then cycloheximide (14126-1, Cayman Chemical, USA) was added to the cells for indicated time. Cells were lysed at different time

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Cycloheximide from Cayman Chemical

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Cycloheximide from Cayman Chemical

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