Description
A topoisomerase II poison; promotes calf thymus topoisomerase II-mediated DNA cleavage at 0.04-40 µg/ml; induces single- and double-stranded DNA breaks in a concentration-dependent manner; inhibits the proliferation of A549 lung cancer cells (IC50 = 0.7 µM); induces cell cycle arrest at the S phase and apoptosis in Tca8113 tongue squamous cell carcinoma cells at 5 mg/L and induces cell cycle arrest at the G2/M phase at 0.15 mg/L; reduces tumor growth and inhibits metastasis in a 3LL murine Lewis lung carcinoma model at 6.5 mg/kg