DBZ from Tocris Bioscience, a Bio-Techne Brand

Product Specs
ItemDBZ
CompanyTocris Bioscience, a Bio-Techne Brand
Price $349.00Supplier Page View Company Product Page
Catalog Number4489/10
Purity98%
Molecular Weight463.48
Molecule NameN-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
FormulaC26H23F2N3O3
StorageStore at -20°C
Quantity10 mg (also 50 mg)

Specifications/Features

Sizes Available: 10 mg (also 50 mg)

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Tocris Bioscience, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956
Fax: 1 (612) 656-4400

Company Profile

Website: http://www.tocris.com

(1) Identification of novel neuroprotectants against vincristine-induced neurotoxicity in iPSC-derived neuronsCellular and molecular life sciences : CMLSJuly 27, 2024Petrova V, Snavely AR, Splaine J, Zhen S, Singh B, Pandey R, Chen K, Cheng A, Hermawan C, Barrett LB, et al.differentiation media containing E6 media, 0.5 µM CHIR-98014, 2 µM A83-01, 1 µM DBZ (Tocris, cat no. 4489/10) and 25 nM PD173074 (Tocris, cat no. 3044/10) for further 11 days. Nocispheres were then collected and

(2) Nociceptor-immune interactomes reveal insult-specific immune signatures of painNature immunologyJuly 1, 2024Jain A, Gyori BM, Hakim S, Jain A, Sun L, Petrova V, Bhuiyan SA, Zhen S, Wang Q, Kawaguchi R, et al.differentiated for 11 days in E6 medium containing 0.5 µM CHIR-98014, 2 µM A83-01, 1 µM DBZ (Tocris, cat. no. 4489/10) and 25 nM PD173074 (Tocris, cat. no. 3044/10). On day 14 from the onset of differentiation, nocispheres

(3) Contribution of Trp63(CreERT2)-labeled cells to alveolar regeneration is independent of tuft cellseLifeSeptember 21, 2022Huang H, Fang Y, Jiang M, Zhang Y, Biermann J, Melms JC, Danielsson JA, Yang Y, Qiang L, Liu J, et al.

(4) Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitroNature geneticsDecember 1, 2021Garcia-Alonso L, Handfield LF, Roberts K, Nikolakopoulou K, Fernando RC, Gardner L, Woodhams B, Arutyunyan A, Polanski K, Hoo R, et al.

(5) Soluble guanylate cyclase signalling mediates etoposide resistance in progressing small cell lung cancerNature communicationsNovember 17, 2021Schenk MW, Humphrey S, Hossain ASMM, Revill M, Pearsall S, Lallo A, Brown S, Bratt S, Galvin M, Descamps T, et al.ALX-420-030-M005) formulated in DMSO, 10 μM DAPT (Merck, D5942) formulated in DMSO, 5 μM DBZ (Tocris, 4489/10), 20 μM ODQ (Cayman Chemical, CAY81410) formulated in DMSO. Cell viability assays were performed by

(6) Principles of signaling pathway modulation for enhancing human naive pluripotency inductionCell stem cellSeptember 2, 2021Bayerl J, Ayyash M, Shani T, Manor YS, Gafni O, Massarwa R, Kalma Y, Aguilera-Castrejon A, Zerbib M, Amir H, et al.

(7) Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoidsCell stem cellJune 3, 2021Huang L, Desai R, Conrad DN, Leite NC, Akshinthala D, Lim CM, Gonzalez R, Muthuswamy LB, Gartner Z, Muthuswamy SK.

(8) Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunctionCommun Med (Lond)January 1, 2021Jeong M, Ocwieja KE, Han D, Wackym PA, Zhang Y, Brown A, Moncada C, Vambutas A, Kanne T, Crain R, et al.

(9) A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular LesionsCirculationOctober 20, 2020Steffes LC, Froistad AA, Andruska A, Boehm M, McGlynn M, Zhang F, Zhang W, Hou D, Tian X, Miquerol L, et al.

(10) The Transcription Co-Repressors MTG8 and MTG16 Regulate Exit of Intestinal Stem Cells From Their Niche and Differentiation Into Enterocyte vs Secretory LineagesGastroenterologyOctober 1, 2020Baulies A, Angelis N, Foglizzo V, Danielsen ET, Patel H, Novellasdemunt L, Kucharska A, Carvalho J, Nye E, De Coppi P, et al.

(11) Resolving the fibrotic niche of human liver cirrhosis at single-cell levelNatureNovember 1, 2019Ramachandran P, Dobie R, Wilson-Kanamori JR, Dora EF, Henderson BEP, Luu NT, Portman JR, Matchett KP, Brice M, Marwick JA, et al.media containing 10% heat-inactivated human serum ± Notch-signalling inhibitor Dibenzazepine (10μM, Bio-Techne, 4489/10) or vehicle (DMSO) control. Cells were fixed in 4% PFA for 30 minutes, permeabilised with 0.3% Triton

(12) Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signalsNature communicationsOctober 11, 2019Yung T, Poon F, Liang M, Coquenlorge S, McGaugh EC, Hui CC, Wilson MD, Nostro MC, Kim TH.

(13) Urothelial organoids originating from Cd49f^high mouse stem cells display Notch-dependent differentiation capacityNature communicationsSeptember 27, 2019Santos CP, Lapi E, Martínez de Villarreal J, Álvaro-Espinosa L, Fernández-Barral A, Barbáchano A, Domínguez O, Laughney AM, Megías D, Muñoz A, et al.

(14) Positive Feedback Defines the Timing, Magnitude, and Robustness of AngiogenesisCell reportsJune 11, 2019Page DJ, Thuret R, Venkatraman L, Takahashi T, Bentley K, Herbert SP.

(15) Cancer-associated fibroblasts suppress SOX2-induced dysplasia in a lung squamous cancer cocultureProceedings of the National Academy of Sciences of the United States of AmericaDecember 11, 2018Chen S, Giannakou A, Wyman S, Gruzas J, Golas J, Zhong W, Loreth C, Sridharan L, Yamin TT, Damelin M, et al.

(16) Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial CellsBioengineering (Basel, Switzerland)October 26, 2018Marshall J, Barnes A, Genever P.

(17) Transcription Factor PROX1 Suppresses Notch Pathway Activation via the Nucleosome Remodeling and Deacetylase Complex in Colorectal Cancer Stem-like CellsCancer researchOctober 15, 2018Högström J, Heino S, Kallio P, Lähde M, Leppänen VM, Balboa D, Wiener Z, Alitalo K.

(18) The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancerThe Journal of clinical investigationApril 2, 2018Khan OM, Carvalho J, Spencer-Dene B, Mitter R, Frith D, Snijders AP, Wood SA, Behrens A.

(19) Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitorsNature communicationsAugust 24, 2017Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, et al.

(20) Stage-specific effects of Notch activation during skeletal myogenesiseLifeSeptember 19, 2016Bi P, Yue F, Sato Y, Wirbisky S, Liu W, Shan T, Wen Y, Zhou D, Freeman J, Kuang S.

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DBZ

DBZ from Tocris Bioscience, a Bio-Techne Brand

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Tocris Bioscience, a Bio-Techne Brand

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DBZ from Tocris Bioscience, a Bio-Techne Brand

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