(+)-Aphidicolin from Cayman Chemical

Product Specs
Item(+)-Aphidicolin
CompanyCayman Chemical
Price $340.00Supplier Page View Company Product Page
Catalog Number14007
Quantity5 mg
Research AreaCell Biology, Cell Cycle, Epigenetics, Transcription, & Translation, RNA, DNA, & Protein Synthesis
FormatA solid
Molecular Weight338.5
Purity≥98%
Storage-20
FormulaC20H34O4
OriginCHE
Source/Expression SystemFungus/Phoma sp. BS 7210
TypeInhibitors

Add to Compare List

Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) The mitotic ATR-Chk1 pathway promotes CDK1 activity for faithful chromosome segregationCell reportsAugust 26, 2025Joo YK, Parrado CR, Li W, Yang R, Black E, Bleichert F, Liu Y, Kabeche L.#13857 S-Trityl-L-Cysteine (STLC),Tocris,Cat #CAS 2799-07-7 Paclitaxel,Tocris,Cat #1097 Aphidicolin,Cayman Chemical,Cat #14007 Human CHEK1 recombinant,Abcam,Cat #69918 GST-Cdk1 recombinant,Sino Biological,Cat #10739-H09B His-Cdk1-CyclinB1,Invitrogen,Cat

(2) The nuclear localization signal of CPSF6 governs post-nuclear import steps of HIV-1 infectionPLOS PathogensJanuary 17, 2025Nicholas Rohlfes, Rajalingam Radhakrishnan, Parmit K. Singh, Gregory J. Bedwell, Alan N. Engelman, Adarsh Dharan, Edward M. Campbellwere purchased from Jackson Immunoresearch Laboratories. Aphidicolin (Cayman Chemicals, catalogue no. 14007) was used to growth arrest cells. Doxycycline hyclate (Sigma-Aldrich, catalogue no. D9891) was used

(3) Glucose limitation protects cancer cells from apoptosis induced by pyrimidine restriction and replication inhibitionNature MetabolismNovember 26, 2024Minwoo Nam, Wenxin Xia, Abdul Hannan Mir, Alexandra Jerrett, Jessica B. Spinelli, Tony T. Huang, Richard PossematoZ-VAD-FMK (#S7023) and ABT-263 (#S1001) from Selleck Chemicals; 3-deazauridine (#23125) and aphidicolin (#14007) from Cayman Chemical; Hydroxyurea (#H8627), cytidine (#C4654), thymidine (#T9250), uridine (#U3003),

(4) The Fanconi anemia pathway induces chromothripsis and ecDNA-driven cancer drug resistanceCellOctober 17, 2024Justin L. Engel, Xiao Zhang, Mingming Wu, Yan Wang, Jose Espejo Espejo Valle-Inclán, Qing Hu, Kidist S. Woldehawariat, Mathijs A. Sanders, Agata Smogorzewska, Jin Chen, et al.31613 Mitomycin C,Sigma-Aldrich,Cat# M4287 Methotrexate,Calbiochem,Cat# 454126 Aphidicolin,Cayman Chemical,Cat# 14007 AZD-1775 (WEE1 inhibitor),MedChemExpress,Cat# HY-10993 "Vemurafenib (PLX4032, BRAF inhibitor)",LC

(5) SMC5/6 Promotes Replication Fork Stability via Negative Regulation of the COP9 SignalosomeInternational Journal of Molecular SciencesJanuary 12, 2024Michelle J. Xu, Philip W. JordanAOB1300) were added at the indicated time points. In place of HU treatment, aphidicolin (Cayman Chemical, 14007) was used at 15 µM. Labeled mESCs were treated with TrypLE and resuspended in PBS at 2 × 105 cells/mL.

(6) GSK-3484862 targets DNMT1 for degradation in cellsNAR CancerMay 17, 2023Qin Chen, Bigang Liu, Yang Zeng, Jee Won Hwang, Nan Dai, Ivan R Corrêa, Marcos R Estecio, Xing Zhang, Margarida A Santos, Taiping Chen, et al.5-Aza-2′-deoxycytidine, Millipore Sigma, A3656), MG132 (Millipore Sigma, 474787), and Aphidicolin (Cayman Chemicals, 14007). Antibodies The primary antibodies used in this study were: DNMT1 [(Cell Signaling Technology (CST),

(7) Adeno-Associated Virus Monoinfection Induces a DNA Damage Response and DNA Repair That Contributes to Viral DNA ReplicationmBioFebruary 28, 2023Ning K, Kuz CA, Cheng F, Feng Z, Yan Z, Qiu J.replication inhibitors. We used HAMNO (#S0148, Selleckchem), T2AA (#21921, Cayman Chemical), aphidicolin (#14007, Cayman Chemical), MK886 (#1311, Tocris Bioscience), and PNR7-02 (#2965, Axon Medchem). Stock solutions

(8) O-GlcNAcylation is crucial for sympathetic neuron development, maintenance, functionality and contributes to peripheral neuropathyFrontiers in neuroscienceJanuary 1, 2023Wu HF, Huang CW, Art J, Liu HX, Hart GW, Zeltner N.(Sigma, R2625, add retinoic acid freshly every feeding). To enhance purity, 0.5 μM aphidicolin (Cayman, 14007) can be added to the symN medium from day 20–30. Please note that BMP4 quality is highly lot-dependent

(9) Norepinephrine transporter defects lead to sympathetic hyperactivity in Familial Dysautonomia modelsNature communicationsNovember 17, 2022Wu HF, Yu W, Saito-Diaz K, Huang CW, Carey J, Lefcort F, Hart GW, Liu HX, Zeltner N.day 20, and every week after that. To eliminate contaminating cells, 0.5–1 μM aphidicolin (Cayman, 14007) can be added to the symN medium from day 20–30. Note BMP4 quality is highly lot dependent. It is

(10) Condensation tendency and planar isotropic actin gradient induce radial alignment in confined monolayerseLifeSeptember 20, 2021Xie T, St Pierre SR, Olaranont N, Brown LE, Wu M, Sun Y.Y27632 (10 µM, Cayman Chemical, cat.no.10005583), and Aphidicolin (1 µg/ml, Cayman Chemical, cat.no.14007) were dissolved in DMSO. Ethylene Glycol Tetraacetic Acid, (EGTA, 2 mM, Santa Cruz Biotechnology, cat.no.

(11) LRR1-mediated replisome disassembly promotes DNA replication by recycling replisome componentsThe Journal of cell biologyAugust 2, 2021Fan Y, Köberlin MS, Ratnayeke N, Liu C, Deshpande M, Gerhardt J, Meyer T.cells were released with full growth media in the presence of 10 µM aphidicolin (Cayman Chemicals; 14007); to release cells from aphidicolin block, cells were washed three times with growth media. RPE-1 hTERT

(12) MEIS-mediated suppression of human prostate cancer growth and metastasis through HOXB13-dependent regulation of proteoglycanseLifeJune 18, 2020VanOpstall C, Perike S, Brechka H, Gillard M, Lamperis S, Zhu B, Brown R, Bhanvadia R, Vander Griend DJ.was complete growth media with 10% FBS. All media (top and bottom) also contained 3 µM Aphidicolin (#14007, Cayman Chemical Company) to inhibit proliferation in order to decrease the confounding effect of differences

(13) Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrolToxicology and Applied PharmacologySeptember 1, 2018Iris Q. Kim, Yusuke Marikawa(567860),10 mM,5ABCD EX527,49843-98-3,Sigma-Aldrich (E7034),50 mM,5EFG Aphidicolin,38966-21-1,Cayman (14007),1 mM,"6AC, 7ABC" Hydroxyurea,127-07-1,Sigma-Aldrich (H8627),100 mM,"6BD, 7ABC" Chemicals used for

(14) Stochastic Endogenous Replication Stress Causes ATR-Triggered Fluctuations in CDK2 Activity that Dynamically Adjust Global DNA Synthesis RatesCell SystemsJuly 1, 2018Leighton H. Daigh, Chad Liu, Mingyu Chung, Karlene A. Cimprich, Tobias Meyercustom MATLAB scripts. The drugs used in this study were: aphidicolin (125 – 1000 nM, Cayman Chemical, #14007), neocarzinostatin (100–200 ng/ml, Sigma-Aldrich, N9162), AZ-20 (2 μM, ATR inhibitor, Cayman Chemical,

(15) Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescenceNature communicationsJanuary 1, 0001"Daigh LH, Saha D, Rosenthal DL, Ferrick KR, Meyer T."3 µM), TPCA-1 (IKK2 inhibitor, Cayman Chemical 15115 used at 1-10 µM), Aphidicolin (Cayman Chemical 14007, used at 1 µM), Hydroxyurea (Sigma Aldrich H8627, used at 1 mM), Mimosine (Cayman Chemical 14337, used

(16) Nucleotide depletion promotes cell fate transitions by inducing DNA replication stressDevelopmental cellJanuary 1, 0001"Do BT, Hsu PP, Vermeulen SY, Wang Z, Hirz T, Abbott KL, Aziz N, Replogle JM, Bjelosevic S, Paolino J, et al."cells,Sykes et al.21,NA Brequinar,Selleck,S6626 Hydroxyurea,Selleck,S1896 Aphidicolin,Cayman Chemical,14007 Teriflunomide,Sigma-Aldrich,SML0936 6-azauridine,Sigma-Aldrich,A1882 Pyrazofurin,Sigma-Aldrich,SML1502 5-fluorouracil,Sigma-Aldrich,F6627 Pyrimethamine,Cayman Chemical

(17) "The cancer testes antigen, HORMAD1, limits genomic instability in cancer cells by protecting stalled replication forks"The Journal of biological chemistryJanuary 1, 0001"Herrera LR, Johnson RA, McGlynn K, Gibbs ZA, Davis AJ, Whitehurst AW."inhibitor (AOBIOUS (NSC15765)) was used at a final concentration of 20 μM. Aphidicolin (Cayman Chemicals (14007)) was used at a final concentration of 2 μM. Camptothecin (Cayman Chemicals (11694)) was used at a final

(18) ATM directs DNA damage responses and proteostasis via genetically separable pathwaysScience signalingJanuary 1, 0001"Lee JH, Mand MR, Kao CH, Zhou Y, Ryu SW, Richards AL, Coon JJ, Paull TT."endogenous ATM and induction of wild-type or mutant ATM were synchronized at G1 with 2 μg/ml aphidicolin (14007, Cayman Chemical) for 17 hr and treated with 1 μM CPT in serum-containing media or 100 μM Arsenite in

(19) Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian EmbryogenesisDevelopmental cellJanuary 1, 0001"Chi F, Sharpley MS, Nagaraj R, Roy SS, Banerjee U."(20μM),Sigma-Aldrich,Cat #D2141 2-Deoxy-D-glucose (1μM),Sigma-Aldrich,Cat #D8375 Aphidicolin (10μM),Cayman Chemical,Cat #14007 Cytochalasin D (500nM),Cayman Chemical,Cat #11330 α-Amanitin (100μg/ml),Cayman Chemical,Cat #17898 Cycloheximide

Be the First to Write a Review!

(+)-Aphidicolin from Cayman Chemical

Description

Cayman Chemical

Citations (19)

Reviews

(+)-Aphidicolin from Cayman Chemical

About Biocompare

Advertise with Us

Specialized Search Tools

Site Map