Description
A potent inhibitor of xanthine oxidase; inhibits bovine milk xanthine oxidase as well as mouse and rat liver xanthine oxidase/xanthine dehydrogenase (IC50s = 1.4, 1.8, and 2.2 nM, respectively); decreases serum urate levels in a potassium oxonate rat model of hyperuricemia (ED50 = 1.5 mg/kg); reduces hepatic macrovesicular steatosis in mice fed a high-fat diet containing trans fatty acids at 1 mg/kg per day; increases CNS expression of GOT2 and improves neurological symptoms in a mouse model of secondary progressive EAE