Torin 2 from Cayman Chemical

Product Specs
ItemTorin 2
CompanyCayman Chemical
Price $370.00Supplier Page View Company Product Page
Catalog Number14185
Quantity25 mg
Research AreaCell Biology, Cell Signaling, PI3K/Akt/mTOR Signaling
FormatA crystalline solid
Molecular Weight432.4
Purity≥98%
Storage-20
FormulaC24H15F3N4O
OriginCHN
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Transient proliferation by reversible YAP and mitogen control of the cyclin D1/p27 ratioCommunications BiologyJanuary 29, 2026Katherine R. Ferrick, Samsara W. Upadhya, Yilin Fan, Nalin Ratnayeke, Mary N. Teruel, Tobias Meyer200 nM MK2206 (Cayman Chemical Cat#11593, CAS#1032350-13-2, AKTi), 100 nM Torin2 (Cayman Chemical Cat#14185, CAS#1223001-51-1, mTORi), 100 nM PD0325901 (Selleck Chemicals Cat#S1036, CAS#391210-10-9, MEKi), 1

(2) A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial statesNature NeuroscienceDecember 1, 2024John F. Tuddenham, Mariko Taga, Verena Haage, Victoria S. Marshe, Tina Roostaei, Charles White, Annie J. Lee, Masashi Fujita, Anthony Khairallah, Ya Zhang, et al.Millipore, 390238), narciclasine (0.1 μM; MilliporeSigma, SML2805), Torin-2 (10 μM; Cayman Chemical Company, 14185) or DMSO (Sigma-Aldrich, 472301) as control and incubated for 24 h before collection. Cells were trypsinized

(3) DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteinsDevelopmental CellDecember 1, 2024Shuyao Kong, Mingyuan Zhu, M. Regina Scarpin, David Pan, Longfei Jia, Ryan E. Martinez, Simon Alamos, Batthula Vijaya Lakshmi Vadde, Hernan G. Garcia, Shu-Bing Qian, et al.planta Starting at 14 days after germination, twice each day for 15 days, 20 μl of 100 μM Torin2 (Cayman Chemical 14185) or 3.2 μM AZD-8055 (Cayman Chemical 16978) containing 0.5% DMSO and 0.5% Tween-20 was applied to the

(4) Uncoupling of mTORC1 from E2F activity maintains DNA damage and senescenceNature communicationsOctober 24, 2024Daigh LH, Saha D, Rosenthal DL, Ferrick KR, Meyer T.(Sigma Aldrich H8627, used at 1 mM), Mimosine (Cayman Chemical 14337, used at 500 µM), Torin 2 (Cayman Chemical 14185, used at 10-100 nM), Rapamycin (Fisher Scientific C0678468, used at 200 nM), CX-5461 (Cayman Chemical

(5) Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 functionJournal of Experimental MedicineOctober 2, 2023Jianfeng Chen, Xinyi Zhang, Xianming Tan, Pengda Liuand glutathione agarose beads (G4510) were purchased from Sigma-Aldrich. Rapamycin (13346), Torin2 (14185), MK2206 (11593), GSK2110 (17988), S6K1-I (15018), Pazopanib (12097), Crizotinib (12087), Everolimus

(6) DRMY1 promotes robust morphogenesis by sustaining translation of a hormone signaling proteinbioRxivApril 12, 2023Shuyao Kong, Mingyuan Zhu, M. Regina Scarpin, David Pan, Longfei Jia, Ryan E. Martinez, Simon Alamos, Batthula Vijaya Lakshmi Vadde, Hernan G. Garcia, Shu-Bing Qian, et al.treatment Starting at 14 days after germination, twice each day for 15 days, 2 nmol of Torin2 (Cayman Chemical 14185) in 20 μl of aqueous solution containing 0.5% DMSO and 0.5% Tween-20 was applied to the center of the

(7) Light regulates alternative splicing outcomes via the TOR kinase pathwayCell ReportsSeptember 7, 2021Stefan Riegler, Lucas Servi, M. Regina Scarpin, Micaela A. Godoy Herz, María G. Kubaczka, Peter Venhuizen, Christian Meyer, Jacob O. Brunkard, Maria Kalyna, Andrea Barta, et al.51-28-5; PubChem Substance ID 24893583 AZD-8055,Chemdea LLC,Cat# CD0348 Torin2,Cayman Chemical,Cat# 14185; CAS# 1223001-51-1 Deposited data,Deposited data,Deposited data Torin2 RNA-seq data,"NCBI SRA, Scarpin

(8) Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian EmbryogenesisDevelopmental cellApril 6, 2020Chi F, Sharpley MS, Nagaraj R, Roy SS, Banerjee U.,Cayman Chemical,Cat #17898 Cycloheximide (10μg/ml),Cayman Chemical,Cat #14126 Torin2 (10nM),Cayman Chemical,Cat #14185 INK128 (100nM),Cayman Chemical,Cat #11811 JTE013 (1μM),Tocris,Cat #2392 SKI-II (0.8μM),Echelon,Cat

(9) Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine TranslationCell reportsJanuary 21, 2020Muendlein HI, Sarhan J, Liu BC, Connolly WM, Schworer SA, Smirnova I, Tang AY, Ilyukha V, Pietruska J, Tahmasebi S, et al.experimental treatments. 4EGi-1 (15362) was purchased from Cayman Chemical and used at 100uM. Torin-2 (14185) was purchased from Cayman Chemical and used at 2.5uM. AKT inhibitor X (14863) was purchased from Cayman Chemical

(10) Blood feeding activates the vitellogenic stage of oogenesis in the mosquito Aedes aegypti through inhibition of glycogen synthase kinase 3 by the insulin and TOR pathwaysDevelopmental biologyOctober 1, 2019Valzania L, Mattee MT, Strand MR, Brown MR.OEH – recombinant protein,Brown/Strand lab, OSI-906,LC Laboratories,Cat#L-5814 Torin 2,Cayman,Cat#14185 CHIR-99021,Selleck Chemicals,Cat#CT99021 JH III,Sigma,Cat#J2000 20-OH ecdysone,Sigma,Cat#H5142 Critical

(11) Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3Cell reportsJune 25, 2019Borghesan M, Fafián-Labora J, Eleftheriadou O, Carpintero-Fernández P, Paez-Ribes M, Vizcay-Barrena G, Swisa A, Kolodkin-Gal D, Ximénez-Embún P, Lowe R, et al.Proteins" ,, Spiroepoxide,Santa Cruz Biotech,sc-202721 GW4869,Sigma-Aldrich,D1692 TORIN-2,Cayman Chemical,14185 Doxycycline,Sigma-Aldrich,D9891 Palbociclib,APExBIO,A8316 4-hydroxytamoxifen,Sigma-Aldrich,T176 Aldehyde/sulfate

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Torin 2 from Cayman Chemical

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Cayman Chemical

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Torin 2 from Cayman Chemical

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