D-AP5 from Cayman Chemical

Product Specs
ItemD-AP5
CompanyCayman Chemical
Price $141.00Supplier Page View Company Product Page
Catalog Number14539
Quantity10 mg
FormatA crystalline solid
Molecular Weight197.1
Purity≥95%
Research AreaBehavioral Neuroscience, Learning & Memory, Neuroscience
Storage-20
FormulaC5H12NO5P
OriginUSA

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) Microbiome-derived metabolites alleviate chronic pain in a reserpine-induced model of fibromyalgiaiScienceApril 17, 2026Shen Chen, Dhanya Shanmuganathan, Wendy L. Imlachproteins" ,, Reserpine,Sigma-Aldrich,Cat#83580; CAS: 50-55-5 NBQX,Abcam,Cat#Ab120046; CAS: 479347-86-9 D-APV,Cayman Chemical,Cat#14539; CAS: 79055-68-8 Gabazine,Abcam,Cat#Ab120042; CAS: 104104-50-9 PF-04418948,Tocris,Cat#4818; CAS: 1078166-57-0 Strychnine hydrochloride

(2) Accumbal calcium-permeable AMPA receptors orchestrate neuronal ensembles underlying social attachmentNature CommunicationsJanuary 7, 2026Mostafa M. El-Kalliny, J. Keenan Kushner, William M. Sheeran, Olivia E. Neilly, Kelly E. Winther, Liza E. Brusman, Michael A. Kelberman, Charles A. Hoeffer, Zoe R. Donaldsonbicuculline methiodide (BMI) (20 μM, Sigma Aldrich, Cat#14343) and D-AP5 (50 μM, Cayman Chemical, #14539), respectively, for 5 min. Neurons were held at -70mV throughout the experiment to isolate AMPA currents.

(3) TRPM2 overactivation drives hyperlipidemia-induced dysfunction of myeloid cells and neurovascular unitsCell Reports MedicineMarch 18, 2025Pengyu Zong, Cindy Li, Jianlin Feng, Zhichao Yue, Nicholas Legere, Albert S. Yu, Fahad Shah, Adrianna Perez, Zhu Li, Evan Jellison, et al.L-NMMA (acetate) (Cayman chemical, 10005031); SN50 (Cayman chemical, 17493); AP5 (Cayman chemical, 14539); MK-801 (Sigma-Aldrich, M107); NP40 (Thermal Fisher Scientific, 28324); Triton X-100 (T-9284), Bovine Serum Albumin

(4) Control of striatal circuit development by the chromatin regulator Zswim6Sci AdvJanuary 17, 2025Kyuhyun Choi, Nathan T. Henderson, Emily R. Feierman, Sean Louzon, Jamie Galanaugh, Felicia Davatolhagh, Isha Bhandaru, David J. Tischfield, Stewart A. Anderson, Erica Korb, et al.acquisition. To record mIPSCs, an ACSF solution containing NBQX, AP5 (50 μM; Cayman Chemical Company, 14539), and PTX was used. The recording pipette was filled with an internal solution consisting of 135 mM

(5) Limbic system synaptic dysfunctions associated with prion disease onsetActa neuropathologica communicationsDecember 20, 2024Foliaki ST, Groveman BR, Dews EA, Williams K, El Soufi H, Schwarz B, Leung JM, Schneider CA, Schwartz CL, Bohrnsen E, et al.block NMDA receptors, slices were continuously superfused with 200 µM D-AP5 (Cayman Chem; Item No. 14539) in aCSF for the duration of the recording. The brain slices were snap-frozen and stored at − 80 °C

(6) Development of covalent chemogenetic K2P channel activatorsCell Chemical BiologyJuly 18, 2024Parker E. Deal, Haerim Lee, Abhisek Mondal, Marco Lolicato, Philipe Ribeiro Furtado de de Mendonça, Holly Black, Seil Jang, Xochina El-Hilali, Clifford Bryant, Ehud Y. Isacoff, et al.paper,NA CAT335,This paper,NA CAT335a,This paper,NA CAT335b,This paper,NA 5-phosphono-D-norvaline (AP5),Cayman,Cat# 14539 Gabazine,Cayman,Cat# 14585 "2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo [f]quinoxaline-7-sulfonamide

(7) Analyses of Conditional Knockout Mice for Pogz, a Gene Responsible for Neurodevelopmental Disorders in Excitatory and Inhibitory Neurons in the BrainCellsMarch 19, 2024Hamada N, Nishijo T, Iwamoto I, Shifman S, Nagata KI.μM, Cayman Chemical Company, Tokyo, Japan, Cat# 14583), D-AP5 (25 μM, Cayman Chemical Company, Cat# 14539), strychnine (0.5 μM) and TTX (0.5 μM). 2.8. Statistical Analyses Cell counting and traces for all

(8) D-serine reconstitutes synaptic and intrinsic inhibitory control of pyramidal neurons in a neurodevelopmental mouse model for schizophreniaNat CommunDecember 12, 2023Xiao-Qin Zhang, Le Xu, Xin-Yi Zhu, Zi-Hang Tang, Yi-Bei Dong, Zhi-Peng Yu, Qing Shang, Zheng-Chun Wang, Hao-Wei Shenisolated after bath application of the NMDAR antagonist D-2-amino-5-phosphonovaleric acid (D-APV, 100 μM, 14539, Cayman). The NMDAR EPSCs were obtained by digital subtraction of the AMPAR EPSCs from the dual (AMPAR

(9) Spinophilin‐dependent regulation of GluN2B‐containing NMDAR‐dependent calcium influx, GluN2B surface expression, and cleaved caspase expressionSynapseMay 1, 2023Asma B. Salek, Emily T. Claeboe, Ruchi Bansal, Nicolas F. Berbari, Anthony J. Baucumprimary blotting are listed in Table S1. Other reagents: D-AP5 (D-145, Alomone, Jerusalem, Israel) or (14539, Cayman Chemicals, Ann Arbor, MI, USA), BSA (A9647–100G, Sigma-Aldrich, St Louis, MO, USA), Leibovitz’s

(10) Enkephalin release from VIP interneurons in the hippocampal CA2/3a region mediates heterosynaptic plasticity and social memoryMolecular psychiatryJune 1, 2022Leroy F, de Solis CA, Boyle LM, Bock T, Lofaro OM, Buss EW, Asok A, Kandel ER, Siegelbaum SA.CGP55845 (1 mM, Tocris #1248), CNQX (2 mM, Cayman Chemical #14618), D-AP5 (50 mM, Cayman Chemical #14539) and naltrindole (0.1 μM, Sigma-Aldrich #N115). Naltrindole application (Fig. 2d–e) or electrical stimulation

(11) Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor AntagonistseNeuroDecember 3, 2021Eric Yuhsiang Wang, Ted Weita Laiketamine (Sigma-Aldrich, catalog #K2753-1G), D-2-amino-5-phosphonovaleric acid (AP5; Cayman, catalog #14539), and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; Sigma-Aldrich, catalog #C104-5MG) were

(12) Drug-Induced Hyperglycemia as a Potential Contributor to Translational Failure of Uncompetitive NMDA Receptor AntagonistseneuroDecember 3, 2021Eric Yuhsiang Wang, Ted Weita Laiketamine (Sigma-Aldrich, catalog #K2753-1G), D-2-amino-5-phosphonovaleric acid (AP5; Cayman, catalog #14539), and 3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP; Sigma-Aldrich, catalog #C104-5MG) were

(13) Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in miceCell ReportsNovember 2, 2021Ludi Zhang, Jing Wang, Chenxu Niu, Yu Zhang, Tiantian Zhu, Dongyang Huang, Jing Ma, Hui Sun, Nikita Gamper, Xiaona Du, et al.and recombinant proteins","Chemicals, peptides, and recombinant proteins" ,, AP-5,Cayman Chemical,14539 Retigabine,Sigma,150812-12-7 Retrobeads,Lumafluor Inc,78R170 CNO,GLPBIO,GC10822 ,, Experimental models

(14) Alternating sources of perisomatic inhibition during behaviorNeuronMarch 1, 2021Barna Dudok et al.were included in the bath to isolate inhibitory currents (in micromoles): 20 D-APV (Cayman Chemical, #14539) and 5 NBQX (Tocris, #1044). For DSI experiments recording pipettes were filled with (in mM): 130 KCl,

(15) Deficits in N-Methyl-D-Aspartate Receptor Function and Synaptic Plasticity in Hippocampal CA1 in APP/PS1 Mouse Model of Alzheimer's DiseaseFrontiers in aging neuroscienceJanuary 1, 2021Xu L, Zhou Y, Hu L, Jiang H, Dong Y, Shen H, Lou Z, Yang S, Ji Y, Ruan L, et al.mV were isolated in the presence of the NMDAR antagonist D-2-amino-5-phosphonovaleric acid (D-APV, 14539, Cayman, United States; 100 μM) with a template with the rise and decay times of 1.2 and 4 ms, respectively.

(16) Phase Separation-Mediated TARP/MAGUK Complex Condensation and AMPA Receptor Synaptic TransmissionNeuronNovember 1, 2019Menglong Zeng, Javier Díaz-Alonso, Fei Ye, Xudong Chen, Jia Xu, Zeyang Ji, Roger A. Nicoll, Mingjie Zhang1063 POPC,Avanti,Cat#850457P DGS-NTA(Ni),Avanti,Cat#790404P PEG5000 PE,Avanti,Cat#880230P PIP2,Echelon Biosciences,Cat#P-4516 D-APV,Cayman Chemical,Cat# 14539 Bicuculline,SIGMA-ALDRICH,Cat # 14340 2-Chloroadenosine,SIGMA-ALDRICH,Cat # C5134 Critical Commercial

(17) Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal ratsBrain, Behavior, and ImmunityMay 1, 2018David G. Litvin, Thomas E. Dick, Corey B. Smith, Frank J. Jaconosteps (5s between steps) and the NMDAR blocker DL-2-amino-5-phosphonopentanoic acid (DL-AP5, 50μM; #14539, Cayman Chemical, Ann Arbor, MI, USA) was delivered into the perfusate. 5 min following DL-AP5 wash-on,

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D-AP5 from Cayman Chemical

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Cayman Chemical

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D-AP5 from Cayman Chemical

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