Dihydroethidium from Cayman Chemical

Product Specs
ItemDihydroethidium
CompanyCayman Chemical
Price $225.00Supplier Page View Company Product Page
Catalog Number12013
Quantity25 mg
Research AreaOxidative Stress & Reactive Species, Reactive Oxygen
FormatA crystalline solid
Molecular Weight315.4
Purity≥98%
Storage-20
FormulaC21H21N3
OriginUSA
TypeInhibitors

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Cayman Chemical

Cayman Chemical Company 1180 East Ellsworth Road

Ann Arbor, Michigan 48108

United States

Phone: (800) 364-9897
(734) 971-3640

Company Profile

Website: http://www.caymanchem.com/

(1) A mitochondrial ROS–dependent antiviral response promotes β cell resilience and is diminished in donors with type 1 diabetesScience Translational MedicineMay 20, 2026Leslie E. Wagner, Olha Melnyk, Alissa N. Muncy, Abigail Turner, Bryce E. Duffett, Charanya Muralidharan, Michelle M. Martinez-Irizarry, Matthew C. Arvin, Kara S. Orr, Wenting Wu, et al.containing 2 μM Hoechst (Thermo Fisher Scientific, cat. no. 62249) and 10 μM DHE (Cayman Chemical, cat. no. 12013) or 10 μM DCFDA (Cayman Chemical, cat. no. 20656) for 25 min and then transferred to imaging dishes

(2) A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasitesNat CommunMarch 28, 2026Andrés Guillén-Samander, Nika Perepelkina, Vendula Horáčková, Hannah M. Behrens, Hely O. Rodriguez Cruz, Joëlle Paolo Mesén-Ramírez, Ana Ribeiro-Holbein, Per Haberkant, Frank Stein, Tobias Spielmannexcision) or 5 (for KS) days. Samples were stained with Hoechst 33342 and Dihydroethidium (Cayman #12013-5) for 20 min at room temperature, and the parasites were inactivated and the staining stopped with

(3) Uncovering functional insights into human pathogenic variants in CDK19 using Drosophila modelsHuman Molecular GeneticsFebruary 8, 2026Karampal S Grewal, Christopher Tam, Jenny Z Liao, Esther M Verheyenquantification Briefly, adult thoraces were isolated in ice-cold PBS and incubated in 30 mM DHE (Cayman Chemical—#12013) for 30 minutes in the dark at room temperature with gentle shaking. Following DHE incubation, tissues

(4) Glabridin attenuates LTA‑induced alveolar macrophage migration via activation of the Nrf2/HO‑1 pathwayMolecular Medicine ReportsNovember 21, 2025Chih-Hsuan Hsia, Chun-Ming Yang, Chao-Chien Chang, Ting-Lin Yen, Arief Gunawan Darmanto, Chi-Chang Huang, Joen-Rong Sheuand methods Reagents and materials GBD (≥98%; cat. no. 11843) and dihydroethidium (DHE; cat. no. 12013) were purchased from Cayman Chemical Company. LTA (cat. no. L2515), dimethyl sulfoxide (DMSO; cat. no.

(5) New Derivatives of 2-(Cyclohexylamino)thiazol-4(5H)-one as Strong Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1: Synthesis, Antiproliferative and Redox-Modulating ActivityInternational Journal of Molecular SciencesSeptember 15, 2025Szymon Baumgart, Daria Kupczyk, Anita Płazińska, Oliwia Koszła, Przemysław Sołek, Aneta Archała, Wojciech Płaziński, Renata Studzińskalevels was carried out using fluorogenic probes: dihydroethidium (Cayman Chemical, Ann Arbor, MI, USA, #12013), DAF-2 diacetate (Cayman Chemical, Ann Arbor, MI, USA, #85165), and Thiol Tracker Violet (Thermo Scientific,

(6) Acute treadmill exercise induces mitochondrial unfolded protein response in skeletal muscle of male ratsBiochimica et Biophysica Acta (BBA) - BioenergeticsApril 1, 2025Ibrahim Turkel, Gokhan Burcin Kubat, Tugba Fatsa, Ozgu Acet, Berkay Ozerklig, Burak Yazgan, Gulcin Simsek, Keshav K. Singh, Sukran Nazan Kosarprocessing. The sections were then rinsed in PBS for 30 s and incubated with 5 μm DHE (catalog no: 12013, Cayman Chemical) in PBS at 37 °C for 30 min. After incubation, the sections were washed twice in PBS

(7) Enhanced BDNF and ROS in Mucosa of Lower Motor Neuron Lesioned Dog Bladder Following Somatic Motor Nerve TransferCellsMarch 11, 2025Frara N, Jawawdeh K, Giaddui D, Tamas IP, Gares RP, McGonagle ER, Hilliard BA, Kolpakov MA, Bright-Rowe L, Braverman AS, et al.(50 µM MgCl2 in Hanks balance salt solution) was made fresh and warmed in a 37 °C water bath. DHE (12013, Cayman Chemical, Ann Arbor, MI, USA) was dissolved in a 5 mM stock solution of DMSO (light sensitive,

(8) IFN-α Induces Heterogenous ROS Production in Human β-CellsbioRxiv : the preprint server for biologyFebruary 20, 2025Wagner LE, Melnyk O, Turner A, Duffett BE, Muralidharan C, Martinez-Irizarry MM, Arvin MC, Orr KS, Manduchi E, Kaestner KH, et al.containing 2μM Hoechst (Thermo Scientific CAT#62249) and 10μM dihydroethidium (Cayman Chemical CAT#12013) or 10μM 2’,7’-dichlorodihydrofluorescein diacetate (Cayman Chemical CAT#20656) in 2mL complete human

(9) Parasitoid wasp venoms degrade Drosophila imaginal discs for successful parasitismSci AdvJanuary 31, 2025Takumi Kamiyama, Yuko Shimada-Niwa, Hitoha Mori, Naoki Tani, Hitomi Takemata-Kawabata, Mitsuki Fujii, Akira Takasu, Minami Katayama, Takayoshi Kuwabara, Kazuki Seike, et al.staining Tissues were dissected in SDM and cultured in new tubes filled with 60 μM dihydroethidium (#12013, Cayman Chemical Company) for 7 min. Samples were washed twice with SDM and fixed for immunostaining. Transmission electron microscopy

(10) Fibrillin-1 deficiency perturbs aortic cholinergic relaxation and adrenergic contraction in a mouse model of early onset progressively severe Marfan syndromeJournal of Vascular ResearchJanuary 17, 2025Anna Cantalupo, Keiichi Asano, Sergey Dikalov, Dylan Gordon, Francesco RamirezIron (II) sulfate heptahydrate,Sigma,12354 Sodium diethyldithiocarbamate trihydrate,Sigma,D3506 DHE,Cayman Chemical,12013 Calcium chloride,Sigma,C4901 Sodium chloride,Sigma,S9888 Potassium chloride,Sigma,P3911 Magnesium sulfate heptahydrate

(11) Inhibiting Ca(2+) channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxiaNature neuroscienceNovember 1, 2024Korte N, Barkaway A, Wells J, Freitas F, Sethi H, Andrews SP, Skidmore J, Stevens B, Attwell D.pixel size), slicing solution was replaced with the same solution containing 8 µM DHE (Cayman Chemical, 12013), and another stack was acquired. To measure ROS in Iba1-expressing microglia and NG2-expressing microglia

(12) Angiogenesis-associated pathways play critical roles in neonatal sepsis outcomesScientific ReportsMay 20, 2024Mario Fidanza, Julie Hibbert, Erica Acton, Danny Harbeson, Elizna Schoeman, Patrycja Skut, Tabitha Woodman, Adrien Eynaud, Lucy Hartnell, Byron Brook, et al.described above. Eight hours post CS challenge we administered dihydroethidium (DHE) (Cayman Chemical: #12013) reconstituted in DMSO at a concentration of 10 μg/g body weight via intraperitoneal injection. After

(13) Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in DrosophilaNature communicationsApril 18, 2024Liao JZ, Chung HL, Shih C, Wong KKL, Dutta D, Nil Z, Burns CG, Kanca O, Park YJ, Zuo Z, et al.detection of ROS86. Briefly, adult thoraxes were dissected in PBS and incubated with 30 µM DHE (Cayman 12013) for 7 min in the dark at room temperature. After rinsing with PBS briefly, samples were fixed in 8%

(14) Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory ActivitiesInternational Journal of Molecular SciencesApril 14, 2023Szymon Baumgart, Daria Kupczyk, Aneta Archała, Oliwia Koszła, Przemysław Sołek, Wojciech Płaziński, Anita Płazińska, Renata Studzińskaassessed with the use of fluorogenic probes: dihydroethidium (Cayman Chemical, Ann Arbor, MI, USA, #12013), DAF-2 diacetate (Cayman Chemical, Ann Arbor, MI, USA, #85165), and Thiol Tracker Violet (Thermo Scientific,

(15) Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growthJournal of Cell ScienceDecember 1, 2020Kenneth Kin Lam Wong, Jenny Zhe Liao, Claire R. Y. Shih, Nicholas Harden, Esther M. Verheyenet al., 2008). Briefly, larval wing discs were dissected in PBS and incubated with 30 µM DHE (Cayman 12013) for 7 min in the dark at room temperature. After rinsing with PBS briefly, samples were fixed in 8%

(16) Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophagesNature communicationsAugust 27, 2020Boytard L, Hadi T, Silvestro M, Qu H, Kumpfbeck A, Sleiman R, Fils KH, Alebrahim D, Boccalatte F, Kugler M, et al.unfixed frozen sections were washed for 1 min in distilled water and then stained for 20 min in DHE (12013, Cayman Chemicals, 5 µM) as per manufacturer’s guidelines and imaged immediately using Zeiss LSM 880

(17) The Protective Roles of Estrogen Receptor β in Renal Calcium Oxalate Crystal Formation via Reducing the Liver Oxalate Biosynthesis and Renal Oxidative Stress-Mediated Cell InjuryOxidative medicine and cellular longevityJanuary 1, 2019Zhu W, Zhao Z, Chou FJ, Zuo L, Liu T, Bushinsky D, Chang C, Zeng G, Yeh S.Peroxide Assay Kit (MAK165) following the manufacturer's protocol. Dihydroethidium (DHE) (Cayman, No. 12013) was diluted in PBS to the final concentration of 10 μM, and 200 μl of DHE-PBS solution was added onto

(18) Entamoeba histolytica Induce Signaling via Raf/MEK/ERK for Neutrophil Extracellular Trap (NET) FormationFrontiers in cellular and infection microbiologyJanuary 1, 2018Fonseca Z, Díaz-Godínez C, Mora N, Alemán OR, Uribe-Querol E, Carrero JC, Rosales C.(catalog no. AS-85711) was from AnaSpec, Inc. (Fremont, CA, USA), and Dihydroethidium (catalog no. 12013) was from Cayman Chemical (Ann Arbor, MI, USA). Diphenyleneiodonium chloride (DPI), an NADPH-oxidase

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Dihydroethidium from Cayman Chemical

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Cayman Chemical

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Dihydroethidium from Cayman Chemical

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